EDG6

Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6
Identifiers
Symbols	EDG6 ; LPC1; S1P4; S1PR4; SLP4
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2799
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

EDG6 (endothelial differentiation gene 1) is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₄.

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.

See also

• Lysophospholipid receptor

Further reading

• Gräler MH, Bernhardt G, Lipp M (1998). "EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue". Genomics. 53 (2): 164–9. doi:10.1006/geno.1998.5491. PMID 9790765.CS1 maint: Multiple names: authors list (link)
• Yamazaki Y, Kon J, Sato K; et al. (2000). "Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway". Biochem. Biophys. Res. Commun. 268 (2): 583–9. doi:10.1006/bbrc.2000.2162. PMID 10679247.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Van Brocklyn JR, Gräler MH, Bernhardt G; et al. (2000). "Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6". Blood. 95 (8): 2624–9. PMID 10753843.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Idzko M, Panther E, Corinti S; et al. (2002). "Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses". FASEB J. 16 (6): 625–7. PMID 11919175.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kveberg L, Bryceson Y, Inngjerdingen M; et al. (2002). "Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases". Eur. J. Immunol. 32 (7): 1856–64. doi:10.1002/1521-4141(200207)32:7<1856::AID-IMMU1856>3.0.CO;2-B. PMID 12115604.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Candelore MR, Wright MJ, Tota LM; et al. (2002). "Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor". Biochem. Biophys. Res. Commun. 297 (3): 600–6. PMID 12270137.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Contos JJ, Ye X, Sah VP, Chun J (2002). "Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene". FEBS Lett. 531 (1): 99–102. PMID 12401211.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vogler R, Sauer B, Kim DS; et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". J. Invest. Dermatol. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gräler MH, Grosse R, Kusch A; et al. (2003). "The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13". J. Cell. Biochem. 89 (3): 507–19. doi:10.1002/jcb.10537. PMID 12761884.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kyi CS, Key SJ, Lloyd TW (2003). "Use of a nasogastric catheter to prevent soft tissue entanglement of the externally ported distractor arm". International journal of oral and maxillofacial surgery. 32 (3): 337–8. doi:10.1054/ijom.2003.0364. PMID 12767884.CS1 maint: Multiple names: authors list (link)
• Holdsworth G, Osborne DA, Pham TT; et al. (2005). "A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor". BMC Biochem. 5: 12. doi:10.1186/1471-2091-5-12. PMID 15298705.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• IUPHAR GPCR Database - Lysophospholipid receptors
• Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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