Dipyridamole (injection)

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Dipyridamole (injection)
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Turky Alkathery, M.D. [2]

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Overview

Dipyridamole (injection) is a coronary vasodilator that is FDA approved for the diagnosis of coronary artery disease in patients who cannot exercise adequately. Common adverse reactions include chest pain, electrocardiogram abnormal, flushing, rash, abdominal discomfort, dizziness, headache, and dyspnea.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

  • Dipyridamole injection is indicated as an alternative to exercise in thallium myocardial perfusion imaging for the evaluation of coronary artery disease in patients who cannot exercise adequately.
  • In a study of about 1100 patients who underwent coronary arteriography and dipyridamole injection assisted thallium imaging, the results of both tests were interpreted blindly and the sensitivity and specificity of the dipyridamole thallium study in predicting the angiographic outcome were calculated. The sensitivity of the dipyridamole test (true positive dipyridamole divided by the total number of patients with positive angiography) was about 85%. The specificity (true negative divided by the number of patients with negative angiograms) was about 50%.
  • In a subset of patients who had exercise thallium imaging as well as dipyridamole thallium imaging, sensitivity and specificity of the two tests was almost identical.

Dosage

  • The dose of intravenous dipyridamole as an adjunct to thallium myocardial perfusion imaging should be adjusted according to the weight of the patient. The recommended dose is 0.142 mg/kg/minute (0.57 mg/kg total) infused over 4 minutes. Although the maximum tolerated dose has not been determined, clinical experience suggests that a total dose beyond 60 mg is not needed for any patient.
  • Prior to intravenous administration, dipyridamole injection should be diluted in at least a 1:2 ratio with sodium chloride injection, 0.45%; sodium chloride injection, 0.9%; or dextrose injection, 5% for a total volume of approximately 20 to 50 mL. Infusion of undiluted dipyridamole may cause local irritation.
  • Thallium-201 should be injected within 5 minutes following the 4-minute infusion of dipyridamole.
  • Do not mix dipyridamole injection with other drugs in the same syringe or infusion container.
  • Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Non–Guideline-Supported Use

  • There is limited information regarding Off-Label Non–Guideline-Supported Use of Dipyridamole (injection) in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

  • Safety and effectiveness in pediatric patients have not been established.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

  • There is limited information regarding Off-Label Guideline-Supported Use of Dipyridamole (injection) in pediatric patients.

Non–Guideline-Supported Use

  • There is limited information regarding Off-Label Non–Guideline-Supported Use of Dipyridamole (injection) in pediatric patients.

Contraindications

Warnings

  • Serious adverse reactions associated with the administration of intravenous dipyridamole have included cardiac death, fatal and non-fatal myocardial infarction, ventricular fibrillation, symptomatic ventricular tachycardia, stroke, transient cerebral ischemia, seizures, anaphylactoid reaction and bronchospasm. There have been reported cases of asystole, sinus node arrest, sinus node depression and conduction block. Patients with abnormalities of cardiac impulse formation/conduction or severe coronary artery disease may be at increased risk for these events.
  • In a study of 3911 patients given intravenous dipyridamole as an adjunct to thallium myocardial perfusion imaging, two types of serious adverse events were reported: 1) four cases of myocardial infarction (0.1%), two fatal (0.05%); and two non-fatal (0.05%); and 2) six cases of severe bronchospasm (0.2%). Although the incidence of these serious adverse events was small (0.3%, 10 of 3911), the potential clinical information to be gained through use of intravenous dipyridamole thallium imaging (see INDICATIONS noting the rate of false positive and false negative results) must be weighed against the risk to the patient. Patients with a history of unstable angina may be at a greater risk for severe myocardial ischemia. Patients with a history of asthma may be at a greater risk for bronchospasm during dipyridamole use.
  • When thallium myocardial perfusion imaging is performed with intravenous dipyridamole, parenteral aminophylline should be readily available for relieving adverse events such as bronchospasm or chest pain. Vital signs should be monitored during, and for 10 to 15 minutes following, the intravenous infusion of dipyridamole and an electrocardiographic tracing should be obtained using at least one chest lead. Should severe chest pain or bronchospasm occur, parenteral aminophylline may be administered by slow intravenous injection (50 to 100 mg over 30 to 60 seconds) in doses ranging from 50 to 250 mg. In the case of severe hypotension, the patient should be placed in a supine position with the head tilted down if necessary, before administration of parenteral aminophylline. If 250 mg of aminophylline does not relieve chest pain symptoms within a few minutes, sublingual nitroglycerin may be administered. If chest pain continues despite use of aminophylline and nitroglycerin, the possibility of myocardial infarction should be considered. If the clinical condition of a patient with an adverse event permits a one minute delay in the administration of parenteral aminophylline, thallium-201 may be injected and allowed to circulate for one minute before the injection of aminophylline. This will allow initial thallium perfusion imaging to be performed before reversal of the pharmacologic effects of dipyridamole on the coronary circulation.

Adverse Reactions

Clinical Trials Experience

  • Adverse reaction information concerning intravenous dipyridamole is derived from a study of 3911 patients in which intravenous dipyridamole was used as an adjunct to thallium myocardial perfusion imaging and from spontaneous reports of adverse reactions and the published literature.
  • Serious adverse events (cardiac death, fatal and non-fatal myocardial infarction, ventricular fibrillation, asystole, sinus node arrest, symptomatic ventricular tachycardia, stroke, transient cerebral ischemia, seizures, anaphylactoid reaction and bronchospasm) are described above.
  • In the study of 3911 patients, the most frequent adverse reactions were: chest pain/angina pectoris (19.7%), electrocardiographic changes (most commonly ST-T changes) (15.9%), headache (12.2%), and dizziness (11.8%).
  • Adverse reactions occurring in greater than 1% of the patients in the study are shown in the following table:
This image is provided by the National Library of Medicine.

L*ess common adverse reactions occurring in 1% or less of the patients within the study included:

  • Other: Myalgia (0.9%), back pain (0.6%), injection site reaction unspecified (0.4%), diaphoresis (0.4%), asthenia (0.3%), malaise (0.3%), arthralgia (0.3%), injection site pain (0.1%), rigor (0.1%), earache (0.1%), tinnitus (0.1%), vision abnormalities unspecified (0.1%), dysgeusia (0.1%), thirst (0.03%), depersonalization (0.03%), eye pain (0.03%), renal pain (0.03%), perineal pain (0.03%), breast pain (0.03%), intermittent claudication (0.03%), leg cramping (0.03%). In additional postmarketing experience, there have been rare reports of allergic reaction including urticaria, pruritus, dermatitis and rash.

Postmarketing Experience

  • There is limited information regarding postmarketing experience.

Drug Interactions

  • Oral maintenance theophylline and other xanthine derivatives such as caffeine may abolish the coronary vasodilatation induced by intravenous dipyridamole administration. This could lead to a false negative thallium imaging result.
  • Myasthenia gravis patients receiving therapy with cholinesterase inhibitors may experience worsening of their disease in the presence of dipyridamole.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): B

  • Reproduction studies performed in mice and rats at daily oral doses of up to 125 mg/kg (15.6 times* the maximum recommended daily human oral dose) and in rabbits at daily oral doses of up to 20 mg/kg (2.5 times* the maximum recommended daily human oral dose) have revealed no evidence of impaired embryonic development due to dipyridamole. There are, however, no adequate and well controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human responses, this drug should be used during pregnancy only if clearly needed.
  • Calculation based on assumed body weight of 50 kg.


Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Dipyridamole (injection) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Dipyridamole (injection) during labor and delivery.

Nursing Mothers

  • Dipyridamole is excreted in human milk.

Pediatric Use

There is no FDA guidance on the use of Dipyridamole (injection) in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Dipyridamole (injection) in geriatric settings.

Gender

There is no FDA guidance on the use of Dipyridamole (injection) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Dipyridamole (injection) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Dipyridamole (injection) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Dipyridamole (injection) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Dipyridamole (injection) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Dipyridamole (injection) in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Intravenous.

Monitoring

  • Vital signs should be monitored during, and for 10 to 15 minutes following, the intravenous infusion of dipyridamole and an electrocardiographic tracing should be obtained using at least one chest lead.

IV Compatibility

  • There is limited information regarding IV Compatibility.

Overdosage

  • No cases of overdosage in humans have been reported. It is unlikely that overdosage will occur because of the nature of use (i.e., single intravenous administration in controlled settings).

Pharmacology

Template:Px
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Dipyridamole (injection)
Systematic (IUPAC) name
2,2',2'',2'''-(4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl)tetraethanol
Identifiers
CAS number 58-32-2
ATC code B01AC07
PubChem 3108
DrugBank DB00975
Chemical data
Formula Template:OrganicBox atomTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox 
Mol. mass 504.626 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability ?
Protein binding 99%
Metabolism Hepatic
Half life Alpha (40 mins), Beta (10 Hours)
Excretion ?
Therapeutic considerations
Pregnancy cat.

B

Legal status

POM(UK) [[Prescription drug|Template:Unicode-only]](US)

Routes oral, IV

Mechanism of Action

  • Dipyridamole is a coronary vasodilator in man. The mechanism of vasodilation has not been fully elucidated, but may result from inhibition of uptake of adenosine, an important mediator of coronary vasodilation. The vasodilatory effects of dipyridamole are abolished by administration of the adenosine receptor antagonist theophylline.
  • How dipyridamole-induced vasodilation leads to abnormalities in thallium distribution and ventricular function is also uncertain but presumably represents a “steal” phenomenon in which relatively intact vessels dilate, and sustain enhanced flow, leaving reduced pressure and flow across areas of hemodynamically important coronary vascular constriction.

Structure

  • Dipyridamole is a coronary vasodilator described as 2,6 bis-(diethanolamino)-4,8-dipiperidino-pyrimido-(5,4-d) pyrimidine. It has the molecular formula C24H40N8O4 and the following structural formula:
This image is provided by the National Library of Medicine.

M. W. 504.64

  • Dipyridamole injection is an odorless, pale yellow liquid which can be diluted in sodium chloride injection or dextrose injection for intravenous administration.
  • Each mL of sterile solution for intravenous administration contains 5 mg dipyridamole, with 2 mg tartaric acid, and 50 mg polyethylene glycol 600. pH is adjusted to 2.2 to 3.2 with hydrochloric acid.

Pharmacodynamics

  • There is limited information regarding pharmacodynamics.

Pharmacokinetics

  • Plasma dipyridamole concentrations decline in a triexponential fashion following intravenous infusion of dipyridamole, with half-lives averaging 3 to 12 minutes, 33 to 62 minutes, and 11.6 to 15 hours. Two minutes following a 0.568 mg/kg dose of intravenous dipyridamole administered as a 4-minute infusion, the mean dipyridamole serum concentration is 4.6±1.3 mcg/mL. The average plasma protein binding of dipyridamole is approximately 99%, primarily to α1 -glycoprotein. Dipyridamole is metabolized in the liver to the glucuronic acid conjugate and excreted with the bile. The average total body clearance is 2.3 to 3.5 mL/min/kg, with an apparent volume of distribution at steady state of 1 to 2.5 L/kg and a central apparent volume of 3 to 5 liters.

Nonclinical Toxicology

  • Carcinogenesis, Mutagenesis, Impairment of Fertility:

In studies in which dipyridamole was administered in the feed at doses of up to 75 mg/kg/day (9.4 times* the maximum recommended daily human oral dose) in mice (up to 128 weeks in males and up to 142 weeks in females) and rats (up to 111 weeks in males and females), there was no evidence of drug related carcinogenesis. Mutagenicity tests of dipyridamole with bacterial and mammalian cell systems were negative. There was no evidence of impaired fertility when dipyridamole was administered to male and female rats at oral doses up to 500 mg/kg/day (63 times* the maximum recommended daily human oral dose). A significant reduction in number of corpora lutea with consequent reduction in implantations and live fetuses was, however, observed at 1250 mg/kg/day.

  • Calculation based on assumed body weight of 50 kg.

Clinical Studies

  • There is limited information regarding Clinical Studies.

How Supplied

  • Dipyridamole Injection, is available in 2 mL and 10 mL ampules:
  • 10 mg/2 mL (5 mg per mL) Box of 10 (List 2043).
  • 50 mg/10 mL (5 mg per mL) Box of 10 (List 2043).

Storage

  • Store between 15°C (59°F) − 25°C (77°F).

Images

Drug Images

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Package and Label Display Panel

This image is provided by the National Library of Medicine.

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Patient Counseling Information

There is limited information regarding Dipyridamole (injection) Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Dipyridamole (injection) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

  • DIPYRIDAMOLE®[5]

Look-Alike Drug Names

  • There is limited information regarding Look-Alike Drug Names.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. Dal Porto R, Faletra F, Picano E, Pirelli S, Moreo A, Varga A (2001). "Safety, feasibility, and diagnostic accuracy of accelerated high-dose dipyridamole stress echocardiography". Am J Cardiol. 87 (5): 520–4. PMID 11230832.
  2. Parthenakis FI, Karidis KS, Zuridakis G, Kanoupakis EM, Chlouverakis GI, Vardas PE (1997). "Left ventricular diastolic filling changes during dipyridamole-induced ischaemia. An echo-Doppler study". Coron Artery Dis. 8 (7): 449–54. PMID 9383606.
  3. Mazeika P, Nihoyannopoulos P, Joshi J, Oakley CM (1991). "Evaluation of dipyridamole-Doppler echocardiography for detection of myocardial ischemia and coronary artery disease". Am J Cardiol. 68 (5): 478–84. PMID 1872275.
  4. Ferrara N, Leosco D, Abete P, Landino P, Caccese P, Sederino S; et al. (1991). "Dipyridamole echocardiography as a useful and safe test in the assessment of coronary artery disease in the elderly". J Am Geriatr Soc. 39 (10): 993–9. PMID 1918787.
  5. "DIPYRIDAMOLE- dipyridamole injection, solution".