Diffuse large B cell lymphoma laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2] Anila Hussain, MD [3]

Overview

Diagnostic Work up for Diffuse Large B cell Lymphoma include Laboratory tests including Complete Blood count (CBC), Comprehensive Metabolic Panel, LDH and Uric acid Levels, Genetic testing, molecular diagnostic assays and immunophenotyping. Screening tests for Hepatitis B, Hepatitis C and HIV are usually recommended after diagnosis.

Laboratory tests

Diffuse large B cell lymphoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Diagnosis
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Biopsy
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Diffuse large B cell lymphoma laboratory tests On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Diffuse large B cell lymphoma laboratory tests All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Diffuse large B cell lymphoma laboratory tests
CDC on Diffuse large B cell lymphoma laboratory tests
Diffuse large B cell lymphoma laboratory tests in the news
Blogs on Diffuse large B cell lymphoma laboratory tests
Directions to Hospitals Treating Diffuse large B cell lymphoma
Risk calculators and risk factors for Diffuse large B cell lymphoma laboratory tests

DLBCL require a complete work-up includes immunophenotypic analysis, cytogenetic analysis (conventional methods and FISH), and molecular diagnostic assays.

Laboratory tests of diffuse large B cell lymphoma include:

• Complete blood count (CBC)
• Comprehensive metabolic panel
• Blood chemistry studies including LDH and Uric acid
• Immunohistochemistry(IHC)
  • CD20, CD3, CD5, CD45, CD10, BCL-2, BCl-6, MYC, IRF-4/ MUM-1, Ki-67
• Flow Cytometry Panel (Establishing Reliable Diagnosis require IHC with or without Flow cytometry)
  • Kappa/ Lambda, CD3, CD5, CD45, CD10, CD19, CD20
• IHC for DLBCL subtypes:
  • Kappa/ Lambda, CD30, CD138, Cyclin/D1, ALK, HHV-8, SOX-11, EBER-ISH
• Cytology (for primary CNS lymphoma only)
• Genetic testing
  • 8q24/MYC translocations
  • Immunoglobulin genes clonally rearranged and hypermutated
  • Mutation of BCL6, MYC, PAX5, PIM1, RhoH/TTFn, TP53 genes
  • Translocations involving c-MYC, BCL6, and IgH genes

• Screening tests for HCV and HBV ( to assess risk of Reactivation following immunotherapy/ chemotherapy) are recommended.
• Screening test for HIV

References

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