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DAFLON 500 is also distributed as: Detralex, Arvenum 500, Alvenor, Ardium, Capiven, Elatec and Venitol
DAFLON 500 abridged prescribing information
Presentation and Composition:
Micronized Purified Flavonoid Fraction 500mg: diosmin 450 mg, flavonoids expressed as hesperidin 50 mg.
Vascular protector and venotonic. DAFLON 500 mg acts on the return vascular system: it reduces venous distensibility and venous stasis; in the microcirculation, it normalizes capillary permeability and reinforces capillary resistance.
Micronization of Daflon 500 mg increases its gastrointestinal absorption compared with nonmicronized diosmin (urinary excretion 57.9% vs 32.7%).
Treatment of organic and idiopathic chronic venous disease of the lower limbs with the following symptoms: heavy legs, pain, nocturnal cramps, edema. Treatment of hemorrhoids and acute hemorrhoidal attacks.
Some cases of minor gastrointestinal and autonomic disorders have been reported, but these never required cessation of treatment.
Pregnancy: experimental studies in animal have not demonstrated any teratogenic effects and no harmful effects have been reported in man to date. Lactation: in the absence of data concerning the diffusion into breast milk, breast-feeding is not recommended during treatment.
Dosage and administration:
In chronic venous disease: 2 tablets daily. In hemorrhoidal disease: - Acute crisis: 6 tablets daily for 4 days, then 4 tablets daily for 3 days. - Chronic treatment: 2 tablets daily.