Clopamide

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Clopamide
Clopamide.png
Clopamide ball-and-stick.png
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
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PubChem CID
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UNII
KEGG
ChEMBL
E number{{#property:P628}}
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Chemical and physical data
FormulaC14H20ClN3O3S
Molar mass345.846 g/mol
3D model (JSmol)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Clopamide (trade name Brinaldix) is a piperidine diuretic.

Mechanism of Action

Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the proximal convoluted tubule (PCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.

References


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