Churg-Strauss syndrome (patient information)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]

Overview

Eosinophilic granulomatosis with polyangiitis previously called Churg-Strauss syndrome involves primarily small and medium sized blood vessels resulting in vessel inflammation. The exact cause of the disease is not known. However, various environmental factors, allergensgenetics, and drugs may play a role in triggering disease process by activating different types of white blood cells. The disease is characterized by the presence of asthma, hypereosinophiliarhinosinusitistingling and numbness of hands and feet (peripheral neuropathy) and multiple organ involvements including skinGI tract, and kidney.

What are the symptoms of Churg-Strauss syndrome

Symptoms of eosinophilic granulomatosis with polyangiitis typically develops through three phases, include prodromal phase, eosinophilic phase, and vasculitis phase. Although these phases cannot be clinically distinguishable.[1]

What causes Churg-Strauss syndrome?

There are no established causes for eosinophilic granulomatosis with polyangiitis. However, various allergensinfectionsvaccinations and drugs may act as a triggering agents, and are responsible for developing disease. Genetics may also play a role.

Who is at highest risk?

Any one can develop eosinophilic granulomatosis with polyangiitis. Studies shown, it occurs mostly between 40-60 years with people having chronic history of asthma and allergic manifestations.

Diagnosis

Physical examination of lungs, heart, nervous system, skin and upper airway tract, along with the following tests can help in finding out eosinophilic granulomatosis with polyangiitis.

When to seek urgent medical care?

You should see the doctor if you experience any of the following:

The above symptoms may also present in association with other diseases, but they have to be evaluated properly by medical professional.

Treatment Options

Where to find medical care for Churg-Strauss syndrome

Directions to Hospitals Treating eosinophilic granulomatosis with polyangiitis

Prevention

Currently, there are no established preventive measures for eosinophilic granulomatosis with polyangiitis.

What to expect (Outlook/Prognosis)?

  • With treatment, the outlook for most patients is good.
  • Studies have shown that most people who receive and cyclophosphamide are doing much better. However, the disease relapses are common.

Possible Complications

Without treatment, eosinophilic granulomatosis with polyangiitis can result in the following complications. Complications depend on organ system involvement.

Sources

References

  1. Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Ruoppolo G, Altissimi G, De Vincentiis M (April 2015). "Churg-Strauss syndrome". Autoimmun Rev. 14 (4): 341–8. doi:10.1016/j.autrev.2014.12.004. PMID 25500434.

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