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Chromoshadow is a protein domain commonly associated with the chromodomain, a protein domain which recognises methylated lysine residues in histon tails. Chromoshadow domains self aggregate, bringing together the nucleosomes to which their proteins are bound and thus condense the chromatin region they are associated with. Condensed chromatin is not able to be transcribed as the transcripiton factors and enzymes are not able to access to DNA sequence in this form. Hence chromoshadow domain containing proteins repress gene transcription.
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