Children's Cancer Study Group

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The Children's Cancer Study Group (CCG) was a U.S. and Canadian clinical trial cooperative group created with the mission of studying childhood cancers. In 2000, CCG merged with several other pediatric cooperative groups to form the Children's Oncology Group (COG). This merger has seen its fair share of problems, especially with regard to integrating the various databases associated with each individual cooperative group. Yet with time and persistence, many of these difficulties will become non-issues. One such initiative to consolidate these databases involves caBIG or cancer BIG, which is guided and supported by the National Cancer Institute (NCI) in Bethesda, Maryland.

Quality Assurance

The Children's Cancer Study Group used to have all of its protocol driven cases reviewed at the Quality Assurance Review Center (QARC). As formerly mandated by the National Cancer Institute (NCI), every radiotherapy department participating in a CCG study used to have to submit their data to QARC for review. QARC is located in Providence, Rhode Island and reviews thousands of cases per year. The center was founded in 1977 as a not-for-profit healthcare organization designed initially to provide quality assurance for CALGB studies. Radiotherapy data from around one-thousand hospitals in both the United States and abroad is reviewed and archived at QARC.

Another center for quality assurance is the Radiological Physics Center (RPC) in Houston, Texas. The primary responsibility of the RPC is to assure the National Cancer Institute (NCI) and its former cooperative group CCG that all participating institutions were following the guidelines set-forth for the physics-related aspects of radiotherapy. Established in 1968, the RPC has consistently received funding from the NCI in order to perform the aforementioned mission.

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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