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Molecular formula C12H22O11
Molar mass 342.30
Solubility 12 g/100mL
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Cellobiose is a disaccharide with the formula [HOCH2CHO(CHOH)3]2O. The molecule is derived from the condensation of two glucose molecules linked in a β(1→4) bond. It can be hydrolyzed by bacteria or cationic ion exchange resins[1] to give glucose. Cellobiose has eight free alcohol (COH) groups and three ether linkages, which give rise to strong -inter- and intra-molecular hydrogen bonds

It can be obtained by enzymatic or acidic hydrolysis of cellulose and cellulose rich materials such as cotton, jute, or paper. Cellulose is a polymer of glucose units linked by β(1→4) bonds.

Treatment of cellulose with acetic anhydride and sulfuric acid, gives cellobiose tetraacetate, which cannot engage in hydrogen bonding and is soluble in nonpolar organic solvents.[2]


  1. Cancerweb.ncl.ac.uk
  2. Braun, G. "α-Cellobiose Octaacetate" Organic Syntheses, Collected Volume 2, p.124 (1943). [1]

External links

de:Zellobiose it:Cellobiosio nl:Cellobiose