Cefotiam

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Cefotiam
Systematic (IUPAC) name
(6R,7R)-7-{[2-(2-amino-1,3-thiazol-4-yl)acetyl]
amino}-3-{[1-(2-dimethylaminoethyl)tetrazol-5-yl]
sulfanylmethyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]
oct-2-ene-2-carboxylic acid
Identifiers
CAS number 61622-34-2
ATC code J01DC07
PubChem 43708
DrugBank APRD00855
Chemical data
Formula C18H23N9O4S3 
Mol. mass 525.631 g/mol
Pharmacokinetic data
Bioavailability 60% (intramuscular)
Protein binding 40%
Metabolism Nil
Half life Approximately 1 hour
Excretion Renal
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Intravenous, intramuscular

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Cefotiam is a second-generation cephalosporin antibiotic.

External links

  • Müller R, Böttger C, Wichmann G (2003). "Suitability of cefotiam and cefuroxime axetil for the perioperative short-term prophylaxis in tonsillectomy patients.". Arzneimittelforschung 53 (2): 126-32. PMID 12642969.
  • Kolben M, Mandoki E, Ulm K, Freitag K (2001). "Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section.". Eur J Clin Microbiol Infect Dis 20 (1): 40-2. PMID 11245321.
  • Shimizu S, Chen K, Miyakawa S (1996). "Cefotiam-induced contact urticaria syndrome: an occupational condition in Japanese nurses.". Dermatology 192 (2): 174-6. PMID 8829507.
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