Canals of Hering
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| Canals of Hering | |
|---|---|
| Dorlands/Elsevier | c_04/12207684 |
The Canals of Hering, or intrahepatic bile ductules, are part of the outflow system of exocrine bile product from the liver.
Contents |
Anatomy
They are found between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule.[1][2] Histologically, the cells of the ductule are described as simple cuboidal epithelium, lined partially by cholangiocytes and hepatocytes. They may not be readily visible but can be differentially stained by cytokeratins CK19 and CK7.
Clinical significance
The Canals of Hering are destroyed early in biliary cirrhosis and may be primary sites of scarring in methotrexate toxicity. Research have indicated the presence of intraorgan stem cells of the liver that can proliferate in disease states.[3]
Eponym
They are named for Ewald Hering.[4]
References
- ↑ Ross, M.H. & Pawlina, W. 2003. Histology: A Text and Atlas, 4th Edition. Lippincott Williams & Wilkins, Philadelphia.
- ↑ Gartner, L.P. & Hiatt, J.L. 2000. Color Atlas of Histology, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia.
- ↑ Saxena, R. & Theise, N. 2004. Canals of Hering: Recent Insights and Current Knowledge, Semin Liver Dis 24: 43-48.
- ↑ synd/6168 at Who Named It
Anatomy of torso, digestive system: Digestive glands | |
|---|---|
| Liver | by region: Left lobe (Caudate lobe, Quadrate lobe) • Right lobe • Transverse fissure of liver
by function: Fibrous capsule of Glisson • Hepatocyte • Space of Disse • Space of Mall • Kupffer cell • Liver sinusoid • Ito cell • Hepatic lobule bile ducts: Bile canaliculus • Canals of Hering • Interlobular bile ducts • Intrahepatic bile ducts • Left and Right hepatic ducts • Common hepatic duct |
| Gallbladder | by region: Body • Fundus • Neck ducts: Cystic duct |
| Pancreas | by region: Tail • Body • Head • Uncinate process
by function: Islets of Langerhans • Exocrine pancreas ducts: Pancreatic duct • Accessory pancreatic duct |
| Common | Common bile duct • Hepatopancreatic ampulla • Sphincter of Oddi |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
