Calcium apatite deposition disease

Jump to navigation Jump to search

WikiDoc Resources for Calcium apatite deposition disease

Articles

Most recent articles on Calcium apatite deposition disease

Most cited articles on Calcium apatite deposition disease

Review articles on Calcium apatite deposition disease

Articles on Calcium apatite deposition disease in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Calcium apatite deposition disease

Images of Calcium apatite deposition disease

Photos of Calcium apatite deposition disease

Podcasts & MP3s on Calcium apatite deposition disease

Videos on Calcium apatite deposition disease

Evidence Based Medicine

Cochrane Collaboration on Calcium apatite deposition disease

Bandolier on Calcium apatite deposition disease

TRIP on Calcium apatite deposition disease

Clinical Trials

Ongoing Trials on Calcium apatite deposition disease at Clinical Trials.gov

Trial results on Calcium apatite deposition disease

Clinical Trials on Calcium apatite deposition disease at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Calcium apatite deposition disease

NICE Guidance on Calcium apatite deposition disease

NHS PRODIGY Guidance

FDA on Calcium apatite deposition disease

CDC on Calcium apatite deposition disease

Books

Books on Calcium apatite deposition disease

News

Calcium apatite deposition disease in the news

Be alerted to news on Calcium apatite deposition disease

News trends on Calcium apatite deposition disease

Commentary

Blogs on Calcium apatite deposition disease

Definitions

Definitions of Calcium apatite deposition disease

Patient Resources / Community

Patient resources on Calcium apatite deposition disease

Discussion groups on Calcium apatite deposition disease

Patient Handouts on Calcium apatite deposition disease

Directions to Hospitals Treating Calcium apatite deposition disease

Risk calculators and risk factors for Calcium apatite deposition disease

Healthcare Provider Resources

Symptoms of Calcium apatite deposition disease

Causes & Risk Factors for Calcium apatite deposition disease

Diagnostic studies for Calcium apatite deposition disease

Treatment of Calcium apatite deposition disease

Continuing Medical Education (CME)

CME Programs on Calcium apatite deposition disease

International

Calcium apatite deposition disease en Espanol

Calcium apatite deposition disease en Francais

Business

Calcium apatite deposition disease in the Marketplace

Patents on Calcium apatite deposition disease

Experimental / Informatics

List of terms related to Calcium apatite deposition disease

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Synonyms and Keywords: Calcific periarthritis; calcific bursitis; periarthritis calcarea; hydroxyapatite rheumatism

Overview

Calcium apatite deposition disease is a chronic condition usually characterized by deposition of calcium apatite crystals within and around connective tissues and tendons, most commonly around the periarticular location. The risk factors for calcium apatite deposition disease are the genetic predisposition to HLA-A1 gene, newly onset adult diabetes, estrogen, and thyroid disorders. The most common site of involvement is shoulder, mostly involving the supraspinatus and infraspinatus tendons. Next common location is hip, followed by the spine. It occurs between the ages of 30–60, most common in females and usually asymptomatic. The patient also present with acute episodes of pain, which is recurrent after one episode. Common symptoms are the pain and swelling of the involved joint. Physical examination shows restricted joint movements and swelling. Diagnosis is made by radiography. MRI is the gold standard for the diagnosis of calcification. Treatment is usually conservative such as NSAIDS, physiotherapy, and hot compresses. Those are refractory to conservative treatment are referred to surgical treatment like open resection, arthroscopic resection, ultrasound-guided needle lavage (barbotage), and extracorporeal shockwave therapy (ESWT).

Historical Perspective

Classification

  • Calcium apatite deposition disease may be classified into two phases based on symptoms:[3]
  • Based on the duration of symptoms, calcium apatite deposition disease may be classified as either acute or chronic.

Pathophysiology

  • The pathogenesis of calcium apatite deposition disease is not clear. Various authors have formulated the different hypothesis about the pathophysiology of calcium apatite deposition disease.
  • Uhthoff and Loebr described the pathogenesis in four phases which include:[4]
  • The HLA-A1 gene has been associated with the development of calcium apatite deposition disease.[5]

Differentiating Calcium Apatite Deposition Disease from other Diseases

Epidemiology and Demographics

Prevalence

  • The prevalence of calcium apatite deposition disease is approximately 7.8% in asymptomatic patients and 42.5% in patients with subacromial pain syndrome.[3]

Age

  • Calcium apatite deposition disease has a bimodal pattern which affects both children around 3 years of age and adult between 30–60 years old.[6][7]

Gender

  • Women are more commonly affected with calcium apatite deposition disease than men.[6]

Race

  • There is no racial predilection for calcium apatite deposition disease.

Risk Factors

Natural History, Complications and Prognosis

  • The majority of patients with calcium apatite deposition disease may remain asymptomatic for an indefinite period of time.
  • Early clinical features include acute pain or chronic mild pain.
  • If left untreated, intraarticular calcification may progress to develop joint destruction.
  • Common complications of calcium apatite deposition disease
    • Intraarticular calcification
    • Joint destruction
    • Milwaukee shoulder syndrome

Diagnosis

Diagnostic Criteria

According to the American association of rheumatology, there is no diagnostic criteria of calcium apatite deposition disease.

Symptoms

Physical Examination

Laboratory Findings

  • There are no specific laboratory findings associated with calcium apatite deposition disease.
  • Some of the general tests indicating inflammation are abnormal which includes:

Imaging Findings

  • X-ray is used to see calcification in affected joint.[4]
  • CT scan is not used to diagnose, but it is used to find out deep tissue infections and soft tissue edema.[14]
  • Ultrasound is not used for diagnosis, but it is used in image-guided treatment of the calcifications.[15]
  • MRI is the imaging modality of choice for calcium apatite deposition disease.
  • On MRI, calcification is characterized by:[16]
    • Homogeneous and discrete calcifications
    • Ill-defined inhomogeneous calcifications
    • Soft tissue edema
Calcific-tendinitis of the shoulder joint
Source :Case courtesy of Dr Andrew Lawson, [17][18]
Calcific tendinitis of the longuscolli muscle
Source:Case courtesy of Dr Behrang Amini,[19][20]


Treatment

Medical Therapy

  • There is the conservative treatment for the pain. Most of the calcifications resolve in size with conservative therapy.[21]
  • Conservative treatment options are NSAIDS, hot compresses, and physiotherapy.
  • Patients refractory to conservative therapy, following options are used:

Surgery

Prevention

  • There is no primary prevention for calcium apatite deposition disease.

References

  1. Hamada J, Ono W, Tamai K, Saotome K, Hoshino T (April 2001). "Analysis of calcium deposits in calcific periarthritis". J. Rheumatol. 28 (4): 809–13. PMID 11327256.
  2. Hamada J, Tamai K, Ono W, Saotome K (February 2006). "Does the nature of deposited basic calcium phosphate crystals determine clinical course in calcific periarthritis of the shoulder?". J. Rheumatol. 33 (2): 326–32. PMID 16465665.
  3. 3.0 3.1 Beckmann NM (2016). "Calcium Apatite Deposition Disease: Diagnosis and Treatment". Radiol Res Pract. 2016: 4801474. doi:10.1155/2016/4801474. PMC 5155096. PMID 28042481.
  4. 4.0 4.1 Uhthoff HK, Loehr JW (July 1997). "Calcific Tendinopathy of the Rotator Cuff: Pathogenesis, Diagnosis, and Management". J Am Acad Orthop Surg. 5 (4): 183–191. PMID 10797220.
  5. 5.0 5.1 Sengar DP, McKendry RJ, Uhthoff HK (March 1987). "Increased frequency of HLA-A1 in calcifying tendinitis". Tissue Antigens. 29 (3): 173–4. PMID 3496685.
  6. 6.0 6.1 Louwerens JK, Sierevelt IN, van Hove RP, van den Bekerom MP, van Noort A (October 2015). "Prevalence of calcific deposits within the rotator cuff tendons in adults with and without subacromial pain syndrome: clinical and radiologic analysis of 1219 patients". J Shoulder Elbow Surg. 24 (10): 1588–93. doi:10.1016/j.jse.2015.02.024. PMID 25870115.
  7. Sakamoto K, Kozuki K (2002). "Calcific tendinitis at the biceps brachii insertion of a child: a case report". J Shoulder Elbow Surg. 11 (1): 88–91. doi:10.1067/mse.2002.119854. PMID 11845156.
  8. Mavrikakis ME, Drimis S, Kontoyannis DA, Rasidakis A, Moulopoulou ES, Kontoyannis S (March 1989). "Calcific shoulder periarthritis (tendinitis) in adult onset diabetes mellitus: a controlled study". Ann. Rheum. Dis. 48 (3): 211–4. PMC 1003723. PMID 2930276.
  9. Harvie P, Pollard TC, Carr AJ (2007). "Calcific tendinitis: natural history and association with endocrine disorders". J Shoulder Elbow Surg. 16 (2): 169–73. doi:10.1016/j.jse.2006.06.007. PMID 17188907.
  10. Kim JK, Park ES (May 2014). "Acute calcium deposits in the hand and wrist; comparison of acute calcium peritendinitis and acute calcium periarthritis". J Hand Surg Eur Vol. 39 (4): 436–9. doi:10.1177/1753193413478393. PMID 23422589.
  11. Garayoa SA, Romero-Muñoz LM, Pons-Villanueva J (December 2010). "Acute compartment syndrome of the forearm caused by calcific tendinitis of the distal biceps". Musculoskelet Surg. 94 (3): 137–9. doi:10.1007/s12306-010-0079-2. PMID 20936391.
  12. Paik NC, Lim CS, Jang HS (2012). "Tendinitis of longus colli: computed tomography, magnetic resonance imaging, and clinical spectra of 9 cases". J Comput Assist Tomogr. 36 (6): 755–61. doi:10.1097/RCT.0b013e318269880c. PMID 23192216.
  13. Horowitz G, Ben-Ari O, Brenner A, Fliss DM, Wasserzug O (June 2013). "Incidence of retropharyngeal calcific tendinitis (longus colli tendinitis) in the general population". Otolaryngol Head Neck Surg. 148 (6): 955–8. doi:10.1177/0194599813482289. PMID 23525848.
  14. Gärtner J, Simons B (May 1990). "Analysis of calcific deposits in calcifying tendinitis". Clin. Orthop. Relat. Res. (254): 111–20. PMID 2157572.
  15. Chiou HJ, Chou YH, Wu JJ, Huang TF, Ma HL, Hsu CC, Chang CY (June 2001). "The role of high-resolution ultrasonography in management of calcific tendonitis of the rotator cuff". Ultrasound Med Biol. 27 (6): 735–43. PMID 11516532.
  16. Garner HW, Whalen JL (October 2013). "Acute calcific tendinosis of the flexor hallucis brevis: case report". Foot Ankle Int. 34 (10): 1451–5. doi:10.1177/1071100713491562. PMID 23729205.
  17. href="https://radiopaedia.org/">Radiopaedia.org
  18. href="https://radiopaedia.org/cases/25858">rID: 25858
  19. href="https://radiopaedia.org/">Radiopaedia.org
  20. href="https://radiopaedia.org/cases/36426">rID: 36426
  21. Cho NS, Lee BG, Rhee YG (March 2010). "Radiologic course of the calcific deposits in calcific tendinitis of the shoulder: does the initial radiologic aspect affect the final results?". J Shoulder Elbow Surg. 19 (2): 267–72. doi:10.1016/j.jse.2009.07.008. PMID 19800263.
  22. Rochwerger A, Franceschi JP, Viton JM, Roux H, Mattei JP (1999). "Surgical management of calcific tendinitis of the shoulder: an analysis of 26 cases". Clin. Rheumatol. 18 (4): 313–6. PMID 10468172.
  23. Louwerens JK, Sierevelt IN, van Noort A, van den Bekerom MP (August 2014). "Evidence for minimally invasive therapies in the management of chronic calcific tendinopathy of the rotator cuff: a systematic review and meta-analysis". J Shoulder Elbow Surg. 23 (8): 1240–9. doi:10.1016/j.jse.2014.02.002. PMID 24774621.