CSDA

Cold shock domain protein A
PDB rendering based on 1h95.
Available structures: 1h95
Identifiers
Symbol(s)	CSDA; CSDA1; DBPA; ZONAB
External IDs	OMIM: 603437 MGI: 2137670 Homologene: 2708
Gene ontology Molecular Function: • DNA binding • double-stranded DNA binding • transcription factor activity • RNA polymerase II transcription factor activity • transcription corepressor activity • protein binding Cellular Component: • nucleus • cytoplasm Biological Process: • negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent • response to cold
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	8531	56449
Ensembl	ENSG00000060138	ENSMUSG00000030189
Uniprot	P16989	Q8BPG0
Refseq	NM_003651 (mRNA) NP_003642 (protein)	NM_011733 (mRNA) NP_035863 (protein)
Location	Chr 12: 10.74 - 10.77 Mb	Chr 6: 131.33 - 131.35 Mb
Pubmed search	[1]	[2]

Cold shock domain protein A, also known as CSDA, is a human gene.

Further reading

• Lloberas J, Soler C, Celada A (1998). "Repression mechanisms of the I-A beta gene of the major histocompatibility complex.". Immunobiology 198 (1-3): 249-63. PMID 9442396.
• Sakura H, Maekawa T, Imamoto F, et al. (1989). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology.". Gene 73 (2): 499-507. PMID 2977358.
• Kudo S, Mattei MG, Fukuda M (1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain.". Eur. J. Biochem. 231 (1): 72-82. PMID 7628487.
• Coles LS, Diamond P, Occhiodoro F, et al. (1996). "Cold shock domain proteins repress transcription from the GM-CSF promoter.". Nucleic Acids Res. 24 (12): 2311-7. PMID 8710501.
• Funke B, Zuleger B, Benavente R, et al. (1996). "The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins.". Nucleic Acids Res. 24 (19): 3821-8. PMID 8871564.
• Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.". Genes Dev. 16 (2): 235-44. doi:10.1101/gad.943102. PMID 11799066.
• Hayashi J, Kajino K, Umeda T, et al. (2003). "Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis.". Int. J. Oncol. 21 (4): 847-50. PMID 12239625.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Coles LS, Bartley MA, Bert A, et al. (2004). "A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization.". Eur. J. Biochem. 271 (3): 648-60. PMID 14728692.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Frankel P, Aronheim A, Kavanagh E, et al. (2005). "RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity.". EMBO J. 24 (1): 54-62. doi:10.1038/sj.emboj.7600497. PMID 15592429.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591-8. doi:10.1038/nmeth776. PMID 16094384.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
• Sourisseau T, Georgiadis A, Tsapara A, et al. (2006). "Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA.". Mol. Cell. Biol. 26 (6): 2387-98. doi:10.1128/MCB.26.6.2387-2398.2006. PMID 16508013.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• MeSH CSDA+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.