CRIP2

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Cysteine-rich protein 2 is a protein that in humans is encoded by the CRIP2 gene.[1][2][3][4]

CRIP2 and the closely related CRIP1 are cysteine-rich proteins containing two LIM domains. They are highly expressed during cardiovascular development and act to bridge serum response factor and GATA proteins and stimulate smooth muscle target genes.[5]

References

  1. Tsui SK, Chan PP, Cheuk CW, Liew CC, Waye MM, Fung KP, Lee CY (Feb 1997). "A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation". Biochem Mol Biol Int. 39 (4): 747–54. PMID 8843343.
  2. Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y (January 1996). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.
  3. Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD (Mar 2000). "Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle". J Biol Chem. 275 (8): 5504–11. doi:10.1074/jbc.275.8.5504. PMID 10681529.
  4. "Entrez Gene: CRIP2 cysteine-rich protein 2".
  5. Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ (January 2003). "Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors". Dev. Cell. 4 (1): 107–18. doi:10.1016/S1534-5807(02)00396-9. PMID 12530967.

External links

Further reading