C3 (complement)
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| complement component 3
| |
| Identifiers | |
| Symbol | C3 |
| Entrez | 718 |
| HUGO | 1318 |
| OMIM | 120700 |
| RefSeq | NM_000064 |
| UniProt | P01024 |
| Other data | |
| EC number | 3.4.21.43 |
| Locus | Chr. 19 p13.3-13.2 |
In immunology, soluble C3-convertase, also known as iC3Bb, catalyzes the proteolytic cleavage of C3 into C3a and C3b as part of the alternative complement system.
C3a
C3a plays an important role in chemotaxis, though not as important a role as C5a.[1]
It is also an anaphylatoxin.
C3b
C3b may bind to microbial cell surfaces within an organism's body. This can lead to the production of surface-bound C3 convertase and thus more C3b components. Also known as C3bBb, this convertase is similar to soluble C3-convertase except that it is membrane bound.
Alternatively, bound C3b may aid in opsonization of the microbe by macrophages.[1] Complement receptor 1 or CR1 on macrophages allows the engaging of C3b covered microbes.
C3b is cleaved into C3c and C3d.
See also
References
External links
- Sahu A, Lambris J (2001). "Structure and biology of complement protein C3, a connecting link between innate and acquired immunity". Immunol Rev 180: 35-48. PMID 11414361.
- Fredslund F, Jenner L, Husted L, Nyborg J, Andersen G, Sottrup-Jensen L (2006). "The structure of bovine complement component 3 reveals the basis for thioester function". J Mol Biol 361 (1): 115-27. PMID 16831446.
- PDB 2B39, PDB 2A73
- domain structure; protein database
- MeSH Complement+C3
Proteins: complement system (C, L, A) | |
|---|---|
| Activators | CLA: C3-convertase - MAC (C6, C7, C8, C9) - L: Mannan-binding lectin - A: Factor P/Properdin |
| Enzymes | C: C1Q/C1R/C1S - C4 - C2 - CLA: C3 - C5 (C5a) - L: MASP1 - MASP2 - A: Factor B - Factor D |
| Inhibitors | CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H |
| Complement receptors | CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a) |
Acute phase proteins |
|---|
| Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-macroglobulin - C-reactive protein - Ceruloplasmin - C3 - Fibrin - Haptoglobin - Haemopexin - Orosomucoid - Serum albumin (negative) - Amyloid (P, A) - Transferrin |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
