Butylscopolamine

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Image:Butylscopolamine skeletal.svg
Butylscopolamine
Systematic (IUPAC) name
[7(S)-(1α,2β,4β,5α,7β)]-9-butyl-7-(3-hydroxy- 1-oxo-2-phenylpropoxy)-9-methyl-3-oxa- 9-azonitricyclo[3.3.1.0(2,4)]nonane
Identifiers
CAS number	146-64-4
ATC code	A03BB01
PubChem	160883
Chemical data
Formula	C21H30NO4+
Mol. mass	360.467 g/mol
Pharmacokinetic data
Bioavailability	<1%
Protein binding	Low
Metabolism	?
Half life	5 hours
Excretion	Renal (50%) and fecal
Therapeutic considerations
Pregnancy cat.	B2(AU)
Legal status	Pharmacy Only (S2)(AU) GSL(UK)
Routes	Oral, rectal, intravenous

Butylscopolamine, also known as scopolamine butylbromide and hyoscine butylbromide is an abdominal-specific antispasmodic. It is marketed under the trade name Buscopan by Boehringer Ingelheim GmbH, Germany, who also offer a combination of butylscopolamine and acetaminophen, marketed under the name Buscopan Plus.

Butylscopolamine is used to treat pain and discomfort caused by abdominal cramps or other spasmodic activity in the digestive system. When taken orally, it cannot enter the bloodstream or otherwise leave the digestive tract, so that it is only able to affect the smooth muscles of the digestive system as it passes through. It is not an analgesic in the normal sense, since it doesn't 'mask' or 'cover over' the pain, but rather works to prevent painful cramps and spasms from occurring in the first place.

Usage

Butylscopolamine is often prescribed at a low dosage, commonly 10mg three times a day, as a means of managing some of the symptoms of Irritable bowel syndrome.

External links

• Detailed Information
• Advice about IBS

v • d • e Drugs for functional gastrointestinal disorders (A03)
Drugs for functional bowel disorders	antimuscarinics: Mebeverine - Dicycloverine - Propantheline papaverine and derivatives: Papaverine - Drotaverine - Moxaverine acting on serotonin receptors: 5-HT3 antagonists (Alosetron, Cilansetron) - 5HT4 agonists (Mosapride, Tegaserod) other: Diisopromine - Isometheptene - Phloroglucinol - Proglumide - Tridihexethyl
Belladonna and derivatives (antimuscarinics)	Atropine - Hyoscyamine - Butylscopolamine - Methylscopolamine
Propulsives	primarily dopamine antagonists (Metoclopramide/Bromopride, Domperidone, Alizapride) - serotonin agonists (Cisapride) - Clebopride

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