Buserelin

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Buserelin
Systematic (IUPAC) name
?
Identifiers
CAS number	57982-77-1
ATC code	L02AE01
PubChem	50225
DrugBank	HMDB03170
Chemical data
Formula	C₆₂H₉₀N₁₆O₁₅
Mol. mass	1299.48 g/mol
Synonyms	D-Ser(Tbu)⁶EA¹⁰LHRH
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	72 to 80 minutes
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	X
Legal status	℞-only
Routes	implant, intranasal

Buserelin is a Gonadotropin-releasing hormone agonist (GnRH agonist). By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, buserelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction.

It is normally delivered via a nasal spray but is also available as an injection.

Buserelin acetate is marketed by Sanofi-Aventis under the brand name Suprefact.

v • d • e Sex hormones and related agents (primarily G03, also L02, H01C) - human endogenous in CAPS
Progestogens: (receptor)	PROGESTERONE,Dienogest, Desogestrel, Drospirenone, Dydrogesterone, Ethisterone, Etonogestrel, Ethynodiol diacetate, Gestodene, Gestonorone, Levonorgestrel, Lynestrenol, Medroxyprogesterone, Megestrol, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Tibolone Selective progesterone receptor modulator: Asoprisnil, CDB-4124 Antiprogestogen: Mifepristone
Androgens: (receptor)	TESTOSTERONE, Androstanolone, Fluoxymesterone, Mesterolone, Methyltestosterone, (see also anabolic steroids) Antiandrogens: Bicalutamide, Cyproterone, Dienogest, Flutamide, Nilutamide, Spironolactone
Estrogens: (receptor)	ESTRADIOL, ESTRIOL, ESTRONE, Chlorotrianisene, Dienestrol, Diethylstilbestrol, Ethinylestradiol, Fosfestrol, Mestranol, Polyestradiol phosphate Selective estrogen receptor modulator: Afimoxifene, Arzoxifene, Bazedoxifene, Clomifene, Fulvestrant, Lasofoxifene, Raloxifene, Tamoxifen, Toremifene Aromatase inhibitor: Aminogluthetimide, Anastrozole, Atamestane, Exemestane, Formestane, Letrozole, Vorozole
Gonadotropins: (FSHR/LHCGR)	ovulation stim.: Clomifene, Urofollitropin Antigonadotropins: Danazol, Gestrinone
GnRH: (receptor)	agonist: Buserelin, Goserelin, Histrelin, Leuprorelin, Nafarelin, Triptorelin antagonist: Abarelix, Cetrorelix, Ganirelix

Articles
WikiDoc Resources for Buserelin
Most recent articles on Buserelin Most cited articles on Buserelin Review articles on Buserelin Articles on Buserelin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Buserelin Images of Buserelin Photos of Buserelin Podcasts & MP3s on Buserelin Videos on Buserelin
Evidence Based Medicine
Cochrane Collaboration on Buserelin Bandolier on Buserelin TRIP on Buserelin
Clinical Trials
Ongoing Trials on Buserelin at Clinical Trials.gov Trial results on Buserelin Clinical Trials on Buserelin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Buserelin NICE Guidance on Buserelin NHS PRODIGY Guidance FDA on Buserelin CDC on Buserelin
Books
Books on Buserelin
News
Buserelin in the news Be alerted to news on Buserelin News trends on Buserelin
Commentary
Blogs on Buserelin
Definitions
Definitions of Buserelin
Patient Resources / Community
Patient resources on Buserelin Discussion groups on Buserelin Patient Handouts on Buserelin Directions to Hospitals Treating Buserelin Risk calculators and risk factors for Buserelin
Healthcare Provider Resources
Symptoms of Buserelin Causes & Risk Factors for Buserelin Diagnostic studies for Buserelin Treatment of Buserelin
Continuing Medical Education (CME)
CME Programs on Buserelin
International
Buserelin en Espanol Buserelin en Francais
Business
Buserelin in the Marketplace Patents on Buserelin
Experimental / Informatics
List of terms related to Buserelin