Bolus (medicine)
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In medicine, a bolus (from Latin bolus, ball) is the administration of a medication, drug or other compound that is given to raise blood concentration to an effective level. The administration can be given intravenously, by intramuscular or subcutaneous injection.
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Bolus placement
The placement of the bolus depends on the systemic levels of the contents desired throughout the body. An intramuscular bolus is used in the administration of vaccines to allow a slow release of the antigen to stimulate the body's immune system and allow time to develop antibodies. Subcutaneous injections are used by heroin addicts (called 'skin popping', referring to the bump formed by the bolus of heroin), to sustain a slow release that staves off withdrawal symptoms without producing euphoria.[1]
A bolus delivered directly to the veins through an intravenous drip allows a much faster delivery which quickly raises the concentration of the substance in the blood to an effective level. This is typically done at the beginning of a treatment or after a removal of medicine from blood (e.g. through dialysis).
Diabetes
Diabetics and health care professionals use bolus to refer to a dosage of fast-acting insulin with a meal (as opposed to basal rate, which is a dose of slow-acting insulin or the continuous pumping a small quantity of fast-acting insulin to cover the glucose output of the liver).[2]
Veterinary medicine
In veterinary medicine a bolus is a large time-release tablet that stays in the rumen of cattle, goats and sheep.
References
- ↑ HIV/AIDS Program: Muscling and skin popping (html) (english). Seattle and King County Public Health Department (2003-11-19). Retrieved on 2007-10-30.
- ↑ Insulin Pump Terminology (2007). Retrieved on 2007-07-13.
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
