bZIP domain

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This article is about the protein domain. For the compression algorithm, see Bzip2.


CREB (top) is a transcription factor capable of binding DNA via the bZIP domain (bottom) and regulating gene expression.
bZIP transcription factor
Identifiers
Symbol	bZIP_1
Pfam	PF00170
InterPro	IPR011616
PROSITE	PDOC00036
SCOP	1ysa
Available PDB structures: 1dh3A:285-339 1t2kD:336-395 1s9kE:257-308 1junB:276-313 1jnmA:254-313 1a02J:257-308 1swiB:249-278 1ce9A:251-279 1uo0A:249-279 1rb5B:249-279 1unwB:249-279 1vzlB:249-279 1untA:249-279 1zimC:249-279 1w5jD:249-279 1zijA:249-279 1rb6A:249-279 2ztaA:249-279 1uo5B:249-279 1rb1C:249-279 1gclC:249-279 1w5gB:249-279 1w5iA:249-279 1uo1A:249-279 1unuB:249-279 1gcmA:249-279 1rb4C:249-279 1uo2B:249-279 1ysaD:226-279 1unzB:249-279 1w5kD:249-279 1ij1A:249-279 1zta :247-279 1ij0A:249-279 1uo3A:249-279 1w5hA:249-279 1ij2A:249-279 1dgcA:227-279 1w5lB:249-279 1unyA:249-279 2b1fB:251-279 2bniB:249-279 1zilA:249-278 1ziiA:249-279 1unvB:249-279 1zikB:249-278 1unxA:249-279 1ij3B:249-279 1uo4A:249-279 1kqlB:255-279 2dgcA:229-277 1piqA:249-279 2b22A:251-279 1lvxA:265-294 1gd2H:74-137 1ci6A:280-339

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required for the dimerization of two DNA binding regions. The DNA binding region comprises a number of basic aminoacids such as arginine and lysine.

bZIP domain containing proteins

AP-1 fos/jun heterodimer that forms a transcription factor
Jun-B transcription factor
CREB cAMP response element transcription factor
OPAQUE2 (O2) transcription factor of the 22-kD zein gene that encodes a class of storage proteins in the endosperm of maize (Zea Mays) kernels

Human proteins containing this domain

ATF1; ATF2; ATF4; ATF5; ATF6; ATF7; BACH1; BACH2; BATF; BATF2; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREB5; CREBL1; CREM; E4BP4; FOSL1; FOSL2; JUN; JUNB; JUND; NFE2; NFE2L2; NFE2L3; SNFT; CREM

External links

bZIP domain entry in the SMART database

v • d • e Protein domains
BZIP - DED - Kringle - PH - SH2 - SH3 - zinc finger - FYVE - PX - ENTH - BAR - PDZ - CARD - SUN - TRIO - C1 - LIM - C2

v • d • e

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (1, 2, 3, 4, 5, 6) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3) • GABPA • MAF (B, F, G, K) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • NEUROD1 • Twist • USF1
(1.3) bHLH-ZIP	Myc • MITF • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)	AP-2

(2) Zinc finger
DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6)
(2.3) Cys₂His₂	General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH: 1, 2) • GLI-Krüppel family (1, 2, 3, YY1) • KLF (2, 4, 5, 6, 10, 11, 12, 13) • Sp1 • zinc finger (3, 35, 43, 146, 148, 165, 217, 268, 281, 350) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys₆	HIVEP1

(3) Helix-turn-helix
domains

(3.1) Homeo domain	ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C6, C8, C9, C13, D1, D3, D4, D9, D10, D11, D12, D13) • NANOG • NKX (2-1, 2-5, 3-1) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7)
(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, L2, M1, N3, O3, O4, P1, P2, P3)
(3.4) Heat Shock Factors	HSF1
(3.5) Tryptophan clusters	ELF (4, 5) • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB
(3.6) TEA domain	transcriptional enhancer factor 1, 2

(4) β-Scaffold factors with
minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (5, C1, C2, C3, C4)
(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)
(4.3) p53	p53
(4.4) MADS box	Mef2 (A, B, C, D) • SRF
(4.7) High mobility group	HNF (1A, 1B) • LEF1 • SOX (3, 4, 6, 9, 10, 13, 18) • SRY • SSRP1
(4.10) Cold-shock domain	CSDA

(0) Other
transcription factors

(0.2) HMGI(Y)	HMGA (1, 2)
(0.3) Pocket domain	Rb • RBL1 • RBL2
(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • Rho/Sigma • R-SMAD