N-acetylgalactosamine kinase

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In enzymology, a N-acetylgalactosamine kinase (EC 2.7.1.157) is an enzyme that catalyzes the chemical reaction

ATP + N-acetyl-D-galactosamine ADP + N-acetyl-alpha-D-galactosamine 1-phosphate

Thus, the two substrates of this enzyme are ATP and N-acetyl-D-galactosamine, whereas its two products are ADP and N-acetyl-alpha-D-galactosamine 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acetyl-D-galactosamine 1-phosphotransferase. Other names in common use include GALK2, GK2, GalNAc kinase, and N-acetylgalactosamine (GalNAc)-1-phosphate kinase.

References

• IUBMB entry for 2.7.1.157
• BRENDA references for 2.7.1.157 (Recommended.)
• PubMed references for 2.7.1.157
• PubMed Central references for 2.7.1.157
• Google Scholar references for 2.7.1.157
• Pastuszak I, Drake R, Elbein AD (1996). "Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation". J. Biol. Chem. 271: 20776–82. PMID 8702831.
• Pastuszak I, O'Donnell J, Elbein AD (1996). "Identification of the GalNAc kinase amino acid sequence". J. Biol. Chem. 271: 23653–6. PMID 8798585.
• Thoden JB, Holden HM (2005). "The molecular architecture of human N-acetyl galactosamine kinase". J. Biol. Chem.. PMID 16006554.

External links

• IUBMB entry for 2.7.1.157

• KEGG entry for 2.7.1.157

• BRENDA entry for 2.7.1.157

• NiceZyme view of 2.7.1.157

• EC2PDB: PDB structures for 2.7.1.157

• PRIAM entry for 2.7.1.157

• PUMA2 entry for 2.7.1.157

• IntEnz: Integrated Enzyme entry for 2.7.1.157

• MetaCyc entry for 2.7.1.157

• Atomic-resolution structures of enzymes belonging to this class

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .