Allergic conjunctivitis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sujaya Chattopadhyay, M.D.[2]

Overview

Allergic conjunctivitis is usually a clinical diagnosis. Laboratory tests are primarily supportive. They may help in differentiating intrinsic and extrinsic forms of the condition and thus, guide the treatment.

Laboratory findings

Skin prick test

IgE estimation

In-vitro tests to detect IgE antibodies to specific allergens are widely used[4] if skin testing is indicated but not advised such as[5]:

Conjunctival allergen challenge

References

  1. La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S; et al. (2013). "Allergic conjunctivitis: a comprehensive review of the literature". Ital J Pediatr. 39: 18. doi:10.1186/1824-7288-39-18. PMC 3640929. PMID 23497516.
  2. Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R; et al. (2008). "Allergy diagnostic testing: an updated practice parameter". Ann Allergy Asthma Immunol. 100 (3 Suppl 3): S1–148. doi:10.1016/s1081-1206(10)60305-5. PMID 18431959.
  3. Wilson AM, Orr LC, Sims EJ, Lipworth BJ (2001). "Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis". Clin Exp Allergy. 31 (1): 61–8. PMID 11167952.
  4. Arasi S, Corsello G, Villani A, Pajno GB (2018). "The future outlook on allergen immunotherapy in children: 2018 and beyond". Ital J Pediatr. 44 (1): 80. doi:10.1186/s13052-018-0519-4. PMC 6042356. PMID 29996875.
  5. 5.0 5.1 Dupuis P, Prokopich CL, Hynes A, Kim H (2020). "A contemporary look at allergic conjunctivitis". Allergy Asthma Clin Immunol. 16: 5. doi:10.1186/s13223-020-0403-9. PMC 6975089 Check |pmc= value (help). PMID 31993069.
  6. Fauquert JL, Jedrzejczak-Czechowicz M, Rondon C, Calder V, Silva D, Kvenshagen BK; et al. (2017). "Conjunctival allergen provocation test : guidelines for daily practice". Allergy. 72 (1): 43–54. doi:10.1111/all.12986. PMID 27430124.
  7. 7.0 7.1 Sánchez-Hernández MC, Montero J, Rondon C, Benitez del Castillo JM, Velázquez E, Herreras JM; et al. (2015). "Consensus document on allergic conjunctivitis (DECA)". J Investig Allergol Clin Immunol. 25 (2): 94–106. PMID 25997302.

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