ATP synthase F0 subunit 6 (or subunit/chain A) (human gene name ATP6) is a subunit of F0 complex of transmembrane F-type ATP synthase.
This subunit is a key component of the proton channel, and may play a direct role in the translocation of protons across the membrane. Catalysis in the F1 complex depends upon the rotation of the central stalk and F0 c-ring, which in turn is driven by the flux of protons through the membrane via the interface
between the F0 c-ring and subunit A. The peripheral stalk links subunit A to the external surface of the F1 domain, and is thought to act as a stator to counter the tendency of subunit A and the F1alpha(3)beta(3) catalytic portion to rotate with the central rotary element[1].
3D structure of E.coli homologue of this subunit was modelled based on electron microscopy data (chain M of PDB: 1c17). It forms a transmembrane 4-α-bundle.
References
↑Walker JE, Runswick MJ, Neuhaus D, Montgomery MG, Carbajo RJ, Kellas FA (2005). "Structure of the F1-binding domain of the stator of bovine F1Fo-ATPase and how it binds an alpha-subunit". J. Mol. Biol. 351 (4): 824–838. PMID16045926.CS1 maint: Multiple names: authors list (link)
Further reading
Torroni A, Achilli A, Macaulay V; et al. (2006). "Harvesting the fruit of the human mtDNA tree". Trends Genet. 22 (6): 339–45. doi:10.1016/j.tig.2006.04.001. PMID16678300.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Ingman M, Kaessmann H, Pääbo S, Gyllensten U (2001). "Mitochondrial genome variation and the origin of modern humans". Nature. 408 (6813): 708–13. doi:10.1038/35047064. PMID11130070.CS1 maint: Multiple names: authors list (link)
Manfredi G, Fu J, Ojaimi J; et al. (2002). "Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus". Nat. Genet. 30 (4): 394–9. doi:10.1038/ng851. PMID11925565.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Torigoe T, Izumi H, Ishiguchi H; et al. (2002). "Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents". J. Biol. Chem. 277 (39): 36534–43. doi:10.1074/jbc.M202605200. PMID12133827.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Mishmar D, Ruiz-Pesini E, Golik P; et al. (2003). "Natural selection shaped regional mtDNA variation in humans". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 171–6. doi:10.1073/pnas.0136972100. PMID12509511.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Ingman M, Gyllensten U (2003). "Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines". Genome Res. 13 (7): 1600–6. doi:10.1101/gr.686603. PMID12840039.
Kong QP, Yao YG, Sun C; et al. (2003). "Phylogeny of east Asian mitochondrial DNA lineages inferred from complete sequences". Am. J. Hum. Genet. 73 (3): 671–6. doi:10.1086/377718. PMID12870132.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Temperley RJ, Seneca SH, Tonska K; et al. (2004). "Investigation of a pathogenic mtDNA microdeletion reveals a translation-dependent deadenylation decay pathway in human mitochondria". Hum. Mol. Genet. 12 (18): 2341–8. doi:10.1093/hmg/ddg238. PMID12915481.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Reuter TY, Medhurst AL, Waisfisz Q; et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. PMID14499622.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Dubot A, Godinot C, Dumur V; et al. (2004). "GUG is an efficient initiation codon to translate the human mitochondrial ATP6 gene". Biochem. Biophys. Res. Commun. 313 (3): 687–93. PMID14697245.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Coble MD, Just RS, O'Callaghan JE; et al. (2004). "Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians". Int. J. Legal Med. 118 (3): 137–46. doi:10.1007/s00414-004-0427-6. PMID14760490.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
Carrozzo R, Rizza T, Stringaro A; et al. (2004). "Maternally-inherited Leigh syndrome-related mutations bolster mitochondrial-mediated apoptosis". J. Neurochem. 90 (2): 490–501. doi:10.1111/j.1471-4159.2004.02505.x. PMID15228605.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
