AM404

AM404
Systematic (IUPAC) name
N-arachidonoylphenolamine
Identifiers
CAS number	?
ATC code	?
PubChem	?
Chemical data
Formula	C26H37NO2
Mol. mass	?
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Metabolite of OTC drug
Routes	?

WikiDoc Resources for AM404
Articles
Most recent articles on AM404 Most cited articles on AM404 Review articles on AM404 Articles on AM404 in N Eng J Med, Lancet, BMJ
Media
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Evidence Based Medicine
Cochrane Collaboration on AM404 Bandolier on AM404 TRIP on AM404
Clinical Trials
Ongoing Trials on AM404 at Clinical Trials.gov Trial results on AM404 Clinical Trials on AM404 at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on AM404 NICE Guidance on AM404 NHS PRODIGY Guidance FDA on AM404 CDC on AM404
Books
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News
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Commentary
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Definitions
Definitions of AM404
Patient Resources / Community
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Healthcare Provider Resources
Symptoms of AM404 Causes & Risk Factors for AM404 Diagnostic studies for AM404 Treatment of AM404
Continuing Medical Education (CME)
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Experimental / Informatics
List of terms related to AM404

AM404 also known as N-arachidonoylphenolamine is an active metabolite of paracetamol (acetaminophen) responsible for all or part of its analgesic action.

Pharmacology

AM404 has been noted as an endogenous cannabinoid reuptake inhibitor, preventing the transport of anandamide and other related compounds back from the synaptic cleft, much in the same way that common SSRI antidepressants prevent the reuptake of serotonin. AM404 is also TRPV1 agonist, and also prevents cyclooxygenase COX-1 and COX-2 and prostaglandin synthesis. AM404 is thought to induce its analgesic action through its activity on the cannabinoid, COX and TRPV systems, all of which are present in pain and thermoregulatory pathways.