ALDOC

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Aldolase C, fructose-bisphosphate
PDB rendering based on 1xfb.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols ALDOC ; ALDC
External IDs Template:OMIM5 Template:MGI HomoloGene21073
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Aldolase C, fructose-bisphosphate, also known as ALDOC, is a human gene.[1]

This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively.[1]

References

  1. 1.0 1.1 "Entrez Gene: ALDOC aldolase C, fructose-bisphosphate".

Further reading

  • Buono P, Mancini FP, Izzo P, Salvatore F (1990). "Characterization of the transcription-initiation site and of the promoter region within the 5' flanking region of the human aldolase C gene". Eur. J. Biochem. 192 (3): 805–11. PMID 2209624.
  • Rocchi M, Vitale E, Covone A; et al. (1989). "Assignment of human aldolase C gene to chromosome 17, region cen----q21.1". Hum. Genet. 82 (3): 279–82. PMID 2731939.
  • Rottmann WH, Deselms KR, Niclas J; et al. (1987). "The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones". Biochimie. 69 (2): 137–45. PMID 3105602.
  • Buono P, Paolella G, Mancini FP; et al. (1988). "The complete nucleotide sequence of the gene coding for the human aldolase C.". Nucleic Acids Res. 16 (10): 4733. PMID 3267224.
  • Tolan DR, Niclas J, Bruce BD, Lebo RV (1987). "Evolutionary implications of the human aldolase-A, -B, -C, and -pseudogene chromosome locations". Am. J. Hum. Genet. 41 (5): 907–24. PMID 3674018.
  • Penhoet E, Rajkumar T, Rutter WJ (1967). "Multiple forms of fructose diphosphate aldolase in mammalian tissues". Proc. Natl. Acad. Sci. U.S.A. 56 (4): 1275–82. PMID 5230152.
  • Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.
  • Kim JH, Lee S, Kim JH; et al. (2002). "Phospholipase D2 directly interacts with aldolase via Its PH domain". Biochemistry. 41 (10): 3414–21. PMID 11876650.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Arakaki TL, Pezza JA, Cronin MA; et al. (2005). "Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function". Protein Sci. 13 (12): 3077–84. doi:10.1110/ps.04915904. PMID 15537755.
  • Buono P, Barbieri O, Alfieri A; et al. (2005). "Diverse human aldolase C gene promoter regions are required to direct specific LacZ expression in the hippocampus and Purkinje cells of transgenic mice". FEBS Lett. 578 (3): 337–44. doi:10.1016/j.febslet.2004.11.032. PMID 15589842.
  • Kim SC, Sprung R, Chen Y; et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.

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