AHNAK

AHNAK nucleoprotein (desmoyokin)
Identifiers
Symbol(s)	AHNAK; AHNAKRS; MGC5395
External IDs	OMIM: 103390 MGI: 1316648 Homologene: 67425
Gene ontology Molecular Function: • protein binding Cellular Component: • nucleus Biological Process: • nervous system development
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	79026	66395
Ensembl	ENSG00000124942	na
Uniprot	Q09666	na
Refseq	NM_001620 (mRNA) NP_001611 (protein)	XM_001052079 (mRNA) XP_001052079 (protein)
Location	Chr 11: 62.02 - 62.07 Mb	na
Pubmed search	[1]	[2]

AHNAK nucleoprotein (desmoyokin), also known as AHNAK, is a human gene.

Further reading

• Shtivelman E, Cohen FE, Bishop JM (1992). "A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure.". Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5472-6. PMID 1608957.
• Kudoh J, Wang Y, Minoshima S, et al. (1995). "Localization of the human AHNAK/desmoyokin gene (AHNAK) to chromosome band 11q12 by somatic cell hybrid analysis and fluorescence in situ hybridization.". Cytogenet. Cell Genet. 70 (3-4): 218-20. PMID 7789175.
• James MR, Richard CW, Schott JJ, et al. (1995). "A radiation hybrid map of 506 STS markers spanning human chromosome 11.". Nat. Genet. 8 (1): 70-6. doi:10.1038/ng0994-70. PMID 7987395.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.
• Gentil BJ, Delphin C, Mbele GO, et al. (2001). "The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B.". J. Biol. Chem. 276 (26): 23253-61. doi:10.1074/jbc.M010655200. PMID 11312263.
• Sussman J, Stokoe D, Ossina N, Shtivelman E (2001). "Protein kinase B phosphorylates AHNAK and regulates its subcellular localization.". J. Cell Biol. 154 (5): 1019-30. doi:10.1083/jcb.200105121. PMID 11535620.
• Wernyj RP, Ewing CM, Isaacs WB (2004). "Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery.". Cell Motil. Cytoskeleton 50 (2): 101-13. doi:10.1002/cm.1044. PMID 11746675.
• Hohaus A, Person V, Behlke J, et al. (2002). "The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton.". FASEB J. 16 (10): 1205-16. doi:10.1096/fj.01-0855com. PMID 12153988.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Straub BK, Boda J, Kuhn C, et al. (2004). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells.". J. Cell. Sci. 116 (Pt 24): 4985-95. doi:10.1242/jcs.00815. PMID 14625392.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Haase H, Pagel I, Khalina Y, et al. (2004). "The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction.". FASEB J. 18 (7): 839-41. doi:10.1096/fj.03-0446fje. PMID 15001564.
• Lee IH, You JO, Ha KS, et al. (2004). "AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C.". J. Biol. Chem. 279 (25): 26645-53. doi:10.1074/jbc.M311525200. PMID 15033986.
• Stiff T, Shtivelman E, Jeggo P, Kysela B (2004). "AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation.". DNA Repair (Amst.) 3 (3): 245-56. doi:10.1016/j.dnarep.2003.11.001. PMID 15177040.
• Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus.". J. Biochem. Mol. Biol. 37 (6): 741-8. PMID 15607035.
• Haase H, Alvarez J, Petzhold D, et al. (2006). "Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation.". FASEB J. 19 (14): 1969-77. doi:10.1096/fj.05-3997com. PMID 16319140.
• Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening.". Cell Cycle 5 (6): 641-6. PMID 16582619.
• De Seranno S, Benaud C, Assard N, et al. (2007). "Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer.". J. Biol. Chem. 281 (46): 35030-8. doi:10.1074/jbc.M606545200. PMID 16984913.