AGTRAP
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| Angiotensin II receptor-associated protein
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| Identifiers | ||||||||
| Symbol(s) | AGTRAP; ATRAP; MGC29646 | |||||||
| External IDs | OMIM: 608729 MGI: 1339977 Homologene: 7621 | |||||||
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| Orthologs | ||||||||
| Human | Mouse | |||||||
| Entrez | 57085 | 11610 | ||||||
| Ensembl | ENSG00000177674 | ENSMUSG00000029007 | ||||||
| Uniprot | Q6RW13 | Q3U7X6 | ||||||
| Refseq | NM_001040194 (mRNA) NP_001035284 (protein) | NM_009642 (mRNA) NP_033772 (protein) | ||||||
| Location | Chr 1: 11.72 - 11.73 Mb | Chr 4: 146.92 - 146.93 Mb | ||||||
| Pubmed search | [1] | [2] | ||||||
Angiotensin II receptor-associated protein, also known as AGTRAP, is a human gene.[1]
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.[1]
References
Further reading
- Daviet L, Lehtonen JY, Tamura K, et al. (1999). "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor.". J. Biol. Chem. 274 (24): 17058-62. PMID 10358057.
- Cui T, Nakagami H, Iwai M, et al. (2001). "ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth.". Biochem. Biophys. Res. Commun. 279 (3): 938-41. doi:10.1006/bbrc.2000.4055. PMID 11162453.
- Wang W, Huang Y, Zhou Z, et al. (2002). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap).". Int. J. Biochem. Cell Biol. 34 (1): 93-102. PMID 11733189.
- Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 171-84. PMID 12107413.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
- Lopez-Ilasaca M, Liu X, Tamura K, Dzau VJ (2004). "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling.". Mol. Biol. Cell 14 (12): 5038-50. doi:10.1091/mbc.E03-06-0383. PMID 12960423.
- Guo DF, Chenier I, Tardif V, et al. (2003). "Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane.". Biochem. Biophys. Res. Commun. 310 (4): 1254-65. PMID 14559250.
- Guo DF, Tardif V, Ghelima K, et al. (2004). "A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells.". J. Biol. Chem. 279 (20): 21109-20. doi:10.1074/jbc.M401544200. PMID 14985364.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
- Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation.". J. Biol. Chem. 280 (13): 12536-41. doi:10.1074/jbc.M500296200. PMID 15668245.
- Tanaka Y, Tamura K, Koide Y, et al. (2005). "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy.". FEBS Lett. 579 (7): 1579-86. doi:10.1016/j.febslet.2005.01.068. PMID 15757644.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
