ACSL1

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Acyl-CoA synthetase long-chain family member 1
Identifiers
Symbol(s) ACSL1; ACS1; FACL1; FACL2; LACS; LACS1; LACS2
External IDs OMIM: 152425 MGI: 102797 Homologene: 37561
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 2180 14081
Ensembl ENSG00000151726 ENSMUSG00000018796
Uniprot P33121 Q6GTG6
Refseq NM_001995 (mRNA)
NP_001986 (protein) 		XM_991183 (mRNA)
XP_996277 (protein)
Location Chr 4: 185.91 - 185.98 Mb Chr 8: 47.97 - 48.03 Mb
Pubmed search [1] [2]

Acyl-CoA synthetase long-chain family member 1, also known as ACSL1, is a human gene.[1]


The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation.[1]


References

  1. ↑ 1.0 1.1 Entrez Gene: ACSL1 acyl-CoA synthetase long-chain family member 1.

Further reading

  • Stanczak H, Stanczak JJ, Singh I (1992). "Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1).". Cytogenet. Cell Genet. 59 (1): 17-9. PMID 1531127.
  • Amigo L, McElroy MC, Morales MN, Bronfman M (1992). "Subcellular distribution and characteristics of ciprofibroyl-CoA synthetase in rat liver. Its possible identity with long-chain acyl-CoA synthetase.". Biochem. J. 284 ( Pt 1): 283-7. PMID 1599407.
  • Abe T, Fujino T, Fukuyama R, et al. (1992). "Human long-chain acyl-CoA synthetase: structure and chromosomal location.". J. Biochem. 111 (1): 123-8. PMID 1607358.
  • Lageweg W, Wanders RJ, Tager JM (1991). "Long-chain-acyl-CoA synthetase and very-long-chain-acyl-CoA synthetase activities in peroxisomes and microsomes from rat liver. An enzymological study.". Eur. J. Biochem. 196 (2): 519-23. PMID 2007410.
  • Suzuki H, Kawarabayasi Y, Kondo J, et al. (1990). "Structure and regulation of rat long-chain acyl-CoA synthetase.". J. Biol. Chem. 265 (15): 8681-5. PMID 2341402.
  • Singh I, Bhushan A, Relan NK, Hashimoto T (1989). "Acyl-CoA ligases from rat brain microsomes: an immunochemical study.". Biochim. Biophys. Acta 963 (3): 509-14. PMID 2973813.
  • Bierbach H (1981). "Studies on long chain fatty acid:CoA ligase from human small intestine.". Gut 21 (8): 689-94. PMID 7429333.
  • Cantú ES, Sprinkle TJ, Ghosh B, Singh I (1996). "The human palmitoyl-CoA ligase (FACL2) gene maps to the chromosome 4q34-q35 region by fluorescence in situ hybridization (FISH) and somatic cell hybrid panels.". Genomics 28 (3): 600-2. doi:10.1006/geno.1995.1199. PMID 7490105.
  • Wu P, Bremer J (1994). "Activation of alkylthioacrylic acids in subcellular fractions of rat tissues: a new spectrophotometric method for assay of acyl-CoA synthetase.". Biochim. Biophys. Acta 1215 (1-2): 87-92. PMID 7948012.
  • Singh I, Lazo O, Kremser K (1993). "Purification of peroxisomes and subcellular distribution of enzyme activities for activation and oxidation of very-long-chain fatty acids in rat brain.". Biochim. Biophys. Acta 1170 (1): 44-52. PMID 8399326.
  • Ghosh B, Barbosa E, Singh I (1996). "Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression.". Mol. Cell. Biochem. 151 (1): 77-81. PMID 8584017.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
  • Malhotra KT, Malhotra K, Lubin BH, Kuypers FA (2000). "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors.". Biochem. J. 344 Pt 1: 135-43. PMID 10548543.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
  • Mashek DG, Bornfeldt KE, Coleman RA, et al. (2005). "Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.". J. Lipid Res. 45 (10): 1958-61. doi:10.1194/jlr.E400002-JLR200. PMID 15292367.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
  • Soupene E, Kuypers FA (2006). "Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains.". BMC Mol. Biol. 7: 21. doi:10.1186/1471-2199-7-21. PMID 16834775.
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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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