ABCC13

ATP-binding cassette, sub-family C (CFTR/MRP), member 13
Identifiers
Symbol(s)	ABCC13; C21orf73; PRED6
External IDs	OMIM: 608835
Gene ontology Molecular Function: • ATP binding • ATPase activity, coupled to transmembrane movement of substances Cellular Component: • nucleus • membrane • integral to membrane Biological Process: • transport
Orthologs
	Human	Mouse
Entrez	150000	na
Pubmed search	[1]	na

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]

Overview

ATP-binding cassette, sub-family C (CFTR/MRP), member 13, also known as ABCC13, is a human gene.

This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.

See also

• ATP-binding cassette transporter
• MeSH ABCC13+protein,+human

Further reading

• Dean M, Annilo T (2005). "Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates.". Annual review of genomics and human genetics 6: 123-42. doi:10.1146/annurev.genom.6.080604.162122. PMID 16124856.
• Annilo T, Dean M (2005). "Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages.". Genomics 84 (1): 34-46. doi:10.1016/j.ygeno.2004.02.010. PMID 15203202.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
• Brun ME, Ruault M, Ventura M, et al. (2003). "Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms.". Gene 312: 41-50. PMID 12909339.
• Yabuuchi H, Takayanagi S, Yoshinaga K, et al. (2003). "ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver.". Biochem. Biophys. Res. Commun. 299 (3): 410-7. PMID 12445816.
• Gardiner K, Slavov D, Bechtel L, Davisson M (2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.". Genomics 79 (6): 833-43. doi:10.1006/geno.2002.6782. PMID 12036298.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311-9. doi:10.1038/35012518. PMID 10830953.
• Allikmets R, Gerrard B, Hutchinson A, Dean M (1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.". Hum. Mol. Genet. 5 (10): 1649-55. PMID 8894702.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.