ABCA7

ATP-binding cassette, sub-family A (ABC1), member 7
Identifiers
Symbol(s)	ABCA7; ABCA-SSN; ABCX; FLJ40025
External IDs	OMIM: 605414 MGI: 1351646 Homologene: 22783
Gene ontology Molecular Function: • nucleotide binding • transporter activity • ATP binding • ATPase activity Cellular Component: • membrane • integral to membrane • ATP-binding cassette (ABC) transporter complex Biological Process: • transport • phagocytosis
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	10347	27403
Ensembl	ENSG00000064687	ENSMUSG00000035722
Uniprot	Q8IZY2	Q8R1I3
Refseq	NM_019112 (mRNA) NP_061985 (protein)	NM_013850 (mRNA) NP_038878 (protein)
Location	Chr 19: 0.99 - 1.02 Mb	Chr 10: 79.4 - 79.42 Mb
Pubmed search	[1]	[2]

ATP-binding cassette, sub-family A (ABC1), member 7, also known as ABCA7, is a human gene.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. Alternative splicing of this gene results in two transcript variants.

See also

• ATP-binding cassette transporter

Further reading

• Kaminski WE, Orsó E, Diederich W, et al. (2000). "Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7).". Biochem. Biophys. Res. Commun. 273 (2): 532-8. doi:10.1006/bbrc.2000.2954. PMID 10873640.
• Niwa M, Maruyama H, Fujimoto T, et al. (2001). "Affinity selection of cDNA libraries by lambda phage surface display.". Gene 256 (1-2): 229-36. PMID 11054552.
• Kaminski WE, Piehler A, Schmitz G (2001). "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene.". Biochem. Biophys. Res. Commun. 278 (3): 782-9. doi:10.1006/bbrc.2000.3880. PMID 11095984.
• Tanaka AR, Ikeda Y, Abe-Dohmae S, et al. (2001). "Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjögren's Syndrome.". Biochem. Biophys. Res. Commun. 283 (5): 1019-25. doi:10.1006/bbrc.2001.4891. PMID 11355874.
• Broccardo C, Osorio J, Luciani MF, et al. (2001). "Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter.". Cytogenet. Cell Genet. 92 (3-4): 264-70. PMID 11435699.
• Iida A, Saito S, Sekine A, et al. (2002). "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8.". J. Hum. Genet. 47 (6): 285-310. doi:10.1007/s100380200041. PMID 12111378.
• Wang N, Lan D, Gerbod-Giannone M, et al. (2003). "ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux.". J. Biol. Chem. 278 (44): 42906-12. doi:10.1074/jbc.M307831200. PMID 12917409.
• Kielar D, Kaminski WE, Liebisch G, et al. (2003). "Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization.". J. Invest. Dermatol. 121 (3): 465-74. doi:10.1046/j.1523-1747.2003.12404.x. PMID 12925201.
• Abe-Dohmae S, Ikeda Y, Matsuo M, et al. (2004). "Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein.". J. Biol. Chem. 279 (1): 604-11. doi:10.1074/jbc.M309888200. PMID 14570867.
• Ikeda Y, Abe-Dohmae S, Munehira Y, et al. (2004). "Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release.". Biochem. Biophys. Res. Commun. 311 (2): 313-8. PMID 14592415.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205-10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
• Hayashi M, Abe-Dohmae S, Okazaki M, et al. (2005). "Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7.". J. Lipid Res. 46 (8): 1703-11. doi:10.1194/jlr.M500092-JLR200. PMID 15930518.
• Jehle AW, Gardai SJ, Li S, et al. (2006). "ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages.". J. Cell Biol. 174 (4): 547-56. doi:10.1083/jcb.200601030. PMID 16908670.

External links

• MeSH ABCA7+protein,+human

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.