2,3-Dimercapto-1-propanesulfonic acid

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2,3-Dimercapto-1-propanesulfonic acid
CAS number 74-61-3
PubChem 20007
MeSH Unithiol
Molecular formula C3H8O3S3
Molar mass 188.289 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

2,3-Dimercapto-1-propanesulfonic acid (abbreviated DMPS) or its sodium salt (known as Unithiol) are chelating agents that form complexes with various heavy metals. It is related to dimercaprol, which is another chelating agent.

The synthesis of DMPS was first reported in 1956 by scientists in the Soviet Union.Template:Fix/category[citation needed] The effects if DMPS on heavy metal poisoning, including with polonium-210 were investigated in the following years. DMPS was found to have some protective effect, prolonging the survival time.[1]

A study was done of workers involved in the production of a calomel skin-bleaching lotion and in direct contact with mercurous chloride, who already showed elevated urine mercury levels. The sodium salt of (DMPS) was found to be effective in lowering the body burden of mercury and in decreasing the urinary mercury concentration to normal levels.[2]


  1. Aposhian, H.V. (1990). "Meso-2, 3-dimercaptosuccinic acid: Chemical, pharmacological and toxicological properties of an orally effective metal chelating agent.". Annual Review of Pharmacology and Toxicology. 30 (1): 279–306. doi:10.1146/annurev.pa.30.040190.001431. 
  2. D. Gonzalez-Ramirez, M. Zuniga-Charles, A. Narro-Juarez, Y. Molina-Recio, K. M. Hurlbut, R. C. Dart and H. V. Aposhian (1998). "DMPS (2,3-Dimercaptopropane-1-sulfonate, Dimaval) Decreases the Body Burden of Mercury in Humans Exposed to Mercurous Chloride" (free full text). Journal of Pharmacology and Experimental Therapy. 287 (1): 8–12. 

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