Steroid 11-beta-hydroxylase
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| cytochrome P450, family 11, subfamily B, polypeptide 1
| |
| Identifiers | |
| Symbol | CYP11B1 |
| Alt. Symbols | CYP11B |
| Entrez | 1584 |
| HUGO | 2591 |
| OMIM | 610613 |
| RefSeq | NM_001026213 |
| UniProt | P15538 |
| Other data | |
| EC number | 1.14.15.4 |
Steroid 11β-hydroxylase is a steroid hydroxylase found in the zona fasciculata.
Contents |
Function
It generates cortisol from 11-deoxycortisol and corticosterone from 11-deoxycorticosterone. Note the extra "–OH" added at the 11 position (near the center, on ring "C"):
|
Corticosterone-2D-skeletal.png
|
Location in pathway
Clinical significance
A mutation is associated with congenital adrenal hyperplasia due to 11β-hydroxylase deficiency.
Additional images
 Corticosteroid biosynthetic pathway in rat |
 Steroid numbering |
External links
Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14) | |
|---|---|
| 1.14.11 - 2-oxoglutarate | Prolyl hydroxylase - Lysyl hydroxylase |
| 1.14.13 - NADH or NADPH | Flavin-containing monooxygenase - Nitric oxide synthase - Cholesterol 7 alpha-hydroxylase - Methane monooxygenase - 3A4 -51A1 |
| 1.14.14 - reduced flavin or flavoprotein | 19A1 - 2D6 - 2E1 |
| 1.14.15 - reduced iron-sulfur protein | 11B1 - 11B2 - 11A1 |
| 1.14.16 - reduced pteridine | Phenylalanine hydroxylase - Tyrosine hydroxylase - Tryptophan hydroxylase |
| 1.14.17 - reduced ascorbate | Dopamine beta hydroxylase |
| 1.14.18-19 - other | Tyrosinase - Stearoyl-CoA desaturase-1 |
| 1.14.99 - miscellaneous | Cyclooxygenase - Heme oxygenase (HMOX1) - Squalene monooxygenase - 17A1 - 21A2 |
Cytochromes, oxygenases: cytochrome P450 (EC 1.14) | |
|---|---|
| CYP1 | A1, A2, B1 |
| CYP2 | A6, A7, A13, B6, C8, C9, C18, C19, D6, E1, F1, J2, R1, S1, U1, W1 |
| CYP3 | A4, A5, A7, A43 |
| CYP4 | A11, A22, B1, F2, F3, F8, F11, F12, F22, V2, X1, Z1 |
| CYP5-20 | CYP5 (A1) - CYP7 (A1, B1) - CYP8 (A1, B1) - CYP11 (A1, B1, B2) - CYP17 (A1) - CYP19 (A1) - CYP20 (A1) |
| CYP21-51 | CYP21 (A2) - CYP24 (A1) - CYP26 (A1, B1, C1) - CYP27 (A1, B1, C1) - CYP39 (A1) - CYP46 (A1) - CYP51 (A1) |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
