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	<updated>2026-04-09T03:13:37Z</updated>
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	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_secondary_prevention&amp;diff=1691068</id>
		<title>Cholesterol emboli syndrome secondary prevention</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_secondary_prevention&amp;diff=1691068"/>
		<updated>2021-02-20T22:33:07Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
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&lt;br /&gt;
{{CMG}} {{AE}}{{NN}} &lt;br /&gt;
==Overview==&lt;br /&gt;
Effective measures for the secondary prevention of [[cholesterol emboli syndrome]] include intake of [[aspirin]] and [[statins]], [[smoking]] cessation,  control of weight, [[blood pressure]] and [[glucose]].&lt;br /&gt;
&lt;br /&gt;
==Secondary Prevention==&lt;br /&gt;
*Effective measures for the secondary prevention of [[cholesterol emboli syndrome]] include &amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**intake of [[Aspirin]] &lt;br /&gt;
**intake of [[Statins]]&lt;br /&gt;
**[[Smoking]] cessation&lt;br /&gt;
**Weight control&lt;br /&gt;
**[[Blood pressure]] control&lt;br /&gt;
**[[Blood glucose]] control&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
[[Category:Needs content]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_surgery&amp;diff=1691067</id>
		<title>Cholesterol emboli syndrome surgery</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_surgery&amp;diff=1691067"/>
		<updated>2021-02-20T22:09:28Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
Please help WikiDoc by adding content here.  It&#039;s easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}} {{AE}}{{NN}} &lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [[cholesterol emboli syndrome]]. [[Endarterectomy]], [[Bypass surgery]], [[Stent]] and [[endograft]] implantation are usually reserved for patients with localized [[cholesterol emboli]].&lt;br /&gt;
==Surgery==&lt;br /&gt;
*Surgery is not the first-line treatment option for patients with [[cholesterol emboli syndrome]]. [[Endarterectomy]], [[Bypass surgery]], [[Stent]] and endograft implantation are usually reserved for patients with localized [[cholesterol emboli]]. &amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;MatchettMcFarland2000&amp;quot;&amp;gt;{{cite journal|last1=Matchett|first1=W. Jean|last2=McFarland|first2=David R.|last3=Eidt|first3=John F.|last4=Moursi|first4=Mohammed M.|title=Blue Toe Syndrome: Treatment with Intra-arterial Stents and Review of Therapies|journal=Journal of Vascular and Interventional Radiology|volume=11|issue=5|year=2000|pages=585–592|issn=10510443|doi=10.1016/S1051-0443(07)61610-8}}&amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;KeenMcCarthy1995&amp;quot;&amp;gt;{{cite journal|last1=Keen|first1=Richard R.|last2=McCarthy|first2=Walter J.|last3=Shireman|first3=Paula K.|last4=Feinglass|first4=Joseph|last5=Pearce|first5=William H.|last6=Durham|first6=Joseph R.|last7=Yao|first7=James S.T.|title=Surgical management of atheroembolization|journal=Journal of Vascular Surgery|volume=21|issue=5|year=1995|pages=773–781|issn=07415214|doi=10.1016/S0741-5214(05)80008-4}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
[[Category:Needs content]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_medical_therapy&amp;diff=1691066</id>
		<title>Cholesterol emboli syndrome medical therapy</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_medical_therapy&amp;diff=1691066"/>
		<updated>2021-02-20T21:47:41Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}} {{AE}}{{NN}} &lt;br /&gt;
==Overview==&lt;br /&gt;
Some pharmacologic medical therapies that can be effective for [[cholesterol emboli syndrome]] include [[statins]], [[corticosteroids]], [[colchicine]], [[cyclophosphamide]] and [[IL1]] antagonists.&lt;br /&gt;
==Medical Therapy==&lt;br /&gt;
*There is no definitive treatment for  [[cholesterol emboli syndrome]]; the mainstay of therapy is supportive care.&lt;br /&gt;
*Pharmacologic medical therapies that can be effective for [[cholesterol emboli syndrome]] include &amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Statins]]&lt;br /&gt;
*** [[Statins]] can stabilize the [[atherosclerotic]] plaques. &amp;lt;ref name=&amp;quot;Akdimvan Leuven2007&amp;quot;&amp;gt;{{cite journal|last1=Akdim|first1=Fatima|last2=van Leuven|first2=Sander|last3=P. Kastelein|first3=John|last4=G. Stroes|first4=Erik|title=Pleiotropic Effects of Statins: Stabilization of the Vulnerable Atherosclerotic Plaque?|journal=Current Pharmaceutical Design|volume=13|issue=10|year=2007|pages=1003–1012|issn=13816128|doi=10.2174/138161207780487548}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
***[[Statins]] reduce [[inflammation]]. &amp;lt;ref name=&amp;quot;TousoulisPsarros2014&amp;quot;&amp;gt;{{cite journal|last1=Tousoulis|first1=Dimitris|last2=Psarros|first2=Costas|last3=Demosthenous|first3=Michael|last4=Patel|first4=Rikhil|last5=Antoniades|first5=Charalambos|last6=Stefanadis|first6=Christodoulos|title=Innate and Adaptive Inflammation as a Therapeutic Target in Vascular Disease|journal=Journal of the American College of Cardiology|volume=63|issue=23|year=2014|pages=2491–2502|issn=07351097|doi=10.1016/j.jacc.2014.01.054}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
***[[Statins]] reduce the risk of developing [[ESRD]] and [[dialysis]] requirement. &amp;lt;ref name=&amp;quot;WoolfsonLachmann1998&amp;quot;&amp;gt;{{cite journal|last1=Woolfson|first1=Robin G|last2=Lachmann|first2=Helen|title=Improvement in renal cholesterol emboli syndrome after simvastatin|journal=The Lancet|volume=351|issue=9112|year=1998|pages=1331–1332|issn=01406736|doi=10.1016/S0140-6736(05)79058-9}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Corticosteroid]]s &amp;lt;ref name=&amp;quot;urlCholesterol crystal embolization (CCE): Improvement of renal function with high-dose corticosteroid treatment Desai M, Ram R, Prayaga A, Dakshinamurty K V - Saudi J Kidney Dis Transpl&amp;quot;&amp;gt;{{cite web |url=https://www.sjkdt.org/text.asp?2011/22/2/327/77621 |title=Cholesterol crystal embolization (CCE): Improvement of renal function with high-dose corticosteroid treatment Desai M, Ram R, Prayaga A, Dakshinamurty K V - Saudi J Kidney Dis Transpl |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid12165941&amp;quot;&amp;gt;{{cite journal |vauthors=Stabellini N, Cerretani D, Russo G, Rizzioli E, Gilli P |title=[Renal atheroembolic disease: evaluation of the efficacy of corticosteroid therapy] |language=Italian |journal=G Ital Nefrol |volume=19 |issue=1 |pages=18–21 |date=2002 |pmid=12165941 |doi= |url=}}&amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;YücelKart-Köseoglu2005&amp;quot;&amp;gt;{{cite journal|last1=Yücel|first1=A. E.|last2=Kart-Köseoglu|first2=H.|last3=Demirhan|first3=B.|last4=Özdemir|first4=F. N.|title=Cholesterol crystal embolization mimicking vasculitis: success with corticosteroid and cyclophosphamide therapy in two cases|journal=Rheumatology International|volume=26|issue=5|year=2005|pages=454–460|issn=0172-8172|doi=10.1007/s00296-005-0012-4}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
***high dose of [[corticosteroid]]s has been shown effective but not in the long term.&lt;br /&gt;
**[[Colchicine]] &amp;lt;ref&amp;gt;{{cite journal|doi=10.1016/j.atherosclerosis.2017.12.02}}&amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;RobertsonMartínez2016&amp;quot;&amp;gt;{{cite journal|last1=Robertson|first1=Stacy|last2=Martínez|first2=Gonzalo J.|last3=Payet|first3=Cloe A.|last4=Barraclough|first4=Jennifer Y.|last5=Celermajer|first5=David S.|last6=Bursill|first6=Christina|last7=Patel|first7=Sanjay|title=Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation|journal=Clinical Science|volume=130|issue=14|year=2016|pages=1237–1246|issn=0143-5221|doi=10.1042/CS20160090}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Cyclophosphamide]]&lt;br /&gt;
** [[IL1]] antagonists might be effective due to their anti-inflammatory effects.&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_other_diagnostic_studies&amp;diff=1690923</id>
		<title>Cholesterol emboli syndrome other diagnostic studies</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_other_diagnostic_studies&amp;diff=1690923"/>
		<updated>2021-02-19T22:44:42Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}}&lt;br /&gt;
==Overview==&lt;br /&gt;
== Other Diagnostic Studies ==&lt;br /&gt;
* Biopsy of lesions can definitely establish the diagnosis of [[cholesterol emboli syndrome]].&amp;lt;ref name=&amp;quot;JucglaMoreso2006&amp;quot;&amp;gt;{{cite journal|last1=Jucgla|first1=Anna|last2=Moreso|first2=Francesc|last3=Muniesa|first3=Cristina|last4=Moreno|first4=Abelardo|last5=Vidaller|first5=Antonio|title=Cholesterol embolism: Still an unrecognized entity with a high mortality rate|journal=Journal of the American Academy of Dermatology|volume=55|issue=5|year=2006|pages=786–793|issn=01909622|doi=10.1016/j.jaad.2006.05.012}}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;{{cite journal|doi=10.1055/s-0032-1305005.}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**On biposy from [[skin]], [[muscle]], [[kidney]] or [[gastrointestinal tract]], [[cholesterol emboli syndrome] is characterized by [[cholesterol crystals]].&amp;lt;ref&amp;gt;{{cite journal|doi=10.1055/s-0032-1305005.}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;ParafJacquot2001&amp;quot;&amp;gt;{{cite journal|last1=Paraf|first1=Francois|last2=Jacquot|first2=Christian|last3=Bloch|first3=Francis|last4=Montpreville|first4=Vincent|last5=Bruneval|first5=Patrick|title=Cholesterol crystal embolization demonstrated on GI biopsy|journal=The American Journal of Gastroenterology|volume=96|issue=12|year=2001|pages=3301–3304|issn=0002-9270|doi=10.1111/j.1572-0241.2001.05329.x}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
** Biopsy of affected organs shows characteristic changes in about half to 75% the clinically diagnosed cases.&lt;br /&gt;
** Biopsy of skin lesions is often revealing in patients with [[cutaneous]] involvement. &lt;br /&gt;
** Transverse sections of affected [[arterioles]], show occlusion of the lumen by biconvex needle-shaped [[cholesterol crystal]]s, which dissolve during histologic processing to leave clefts, surrounded by fibrin and [[platelet thrombi]], sometimes in association with foreign-body [[giant cells]] and [[intimal]] thickening.&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_other_diagnostic_studies&amp;diff=1690922</id>
		<title>Cholesterol emboli syndrome other diagnostic studies</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_other_diagnostic_studies&amp;diff=1690922"/>
		<updated>2021-02-19T22:41:30Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}}&lt;br /&gt;
==Overview==&lt;br /&gt;
== Other Diagnostic Studies ==&lt;br /&gt;
* Biopsy of lesions can definitely establish the diagnosis of [[cholesterol emboli syndrome]]&amp;lt;ref name=&amp;quot;JucglaMoreso2006&amp;quot;&amp;gt;{{cite journal|last1=Jucgla|first1=Anna|last2=Moreso|first2=Francesc|last3=Muniesa|first3=Cristina|last4=Moreno|first4=Abelardo|last5=Vidaller|first5=Antonio|title=Cholesterol embolism: Still an unrecognized entity with a high mortality rate|journal=Journal of the American Academy of Dermatology|volume=55|issue=5|year=2006|pages=786–793|issn=01909622|doi=10.1016/j.jaad.2006.05.012}}&amp;lt;/ref&amp;gt;&amp;lt;ref&amp;gt;{{cite journal|doi=10.1055/s-0032-1305005.}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*:*On biposy from [[skin]], [[muscle]], [[kidney]] or [[gastrointestinal tract]], [[cholesterol emboli syndrome] is characterized by [[cholesterol crystals]].&amp;lt;ref&amp;gt;{{cite journal|doi=10.1055/s-0032-1305005.}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&amp;lt;ref name=&amp;quot;ParafJacquot2001&amp;quot;&amp;gt;{{cite journal|last1=Paraf|first1=Francois|last2=Jacquot|first2=Christian|last3=Bloch|first3=Francis|last4=Montpreville|first4=Vincent|last5=Bruneval|first5=Patrick|title=Cholesterol crystal embolization demonstrated on GI biopsy|journal=The American Journal of Gastroenterology|volume=96|issue=12|year=2001|pages=3301–3304|issn=0002-9270|doi=10.1111/j.1572-0241.2001.05329.x}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*:* Biopsy of affected organs shows characteristic changes in about half to 75% the clinically diagnosed cases.&lt;br /&gt;
*:* Biopsy of skin lesions is often revealing in patients with cutaneous involvement. &lt;br /&gt;
*:* Transverse sections of affected arterioles, show occlusion of the lumen by biconvex needle-shaped [[cholesterol crystal]]s, which dissolve during histologic processing to leave clefts, surrounded by fibrin and platelet thrombi, sometimes in association with foreign-body giant cells and intimal thickening.&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_MRI&amp;diff=1690921</id>
		<title>Cholesterol emboli syndrome MRI</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_MRI&amp;diff=1690921"/>
		<updated>2021-02-19T22:27:23Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
Please help WikiDoc by adding content here.  It&#039;s easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.&lt;br /&gt;
==Overview==&lt;br /&gt;
There are no MRI findings associated with [[cholesterol emboli syndrome]].&lt;br /&gt;
&lt;br /&gt;
==Key MRI Findings in (cholesterol emboli syndrome)==&lt;br /&gt;
There are no MRI findings associated with [[cholesterol emboli syndrome]].&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
[[Category:Needs content]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_x_ray&amp;diff=1690918</id>
		<title>Cholesterol emboli syndrome x ray</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_x_ray&amp;diff=1690918"/>
		<updated>2021-02-19T22:23:50Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
Please help WikiDoc by adding content here.  It&#039;s easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.&lt;br /&gt;
==Overview==&lt;br /&gt;
There are no chest x-ray findings associated with [[cholesterol emboli syndrome]].&lt;br /&gt;
&lt;br /&gt;
==Key Chest X-Ray Findings in (cholesterol emboli syndrome)==&lt;br /&gt;
There are no chest x-ray findings associated with [[cholesterol emboli syndrome]].&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
[[Category:Needs content]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_electrocardiogram&amp;diff=1690917</id>
		<title>Cholesterol emboli syndrome electrocardiogram</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_electrocardiogram&amp;diff=1690917"/>
		<updated>2021-02-19T22:18:33Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
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==Overview==&lt;br /&gt;
There are no ECG findings associated with [[cholesterol emboli syndrome]].&lt;br /&gt;
==Key EKG Findings in (cholesterol emboli syndrome)==&lt;br /&gt;
There are no ECG findings associated with [[cholesterol emboli syndrome]].&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
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		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_laboratory_findings&amp;diff=1690916</id>
		<title>Cholesterol emboli syndrome laboratory findings</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_laboratory_findings&amp;diff=1690916"/>
		<updated>2021-02-19T22:15:44Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
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&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}}&lt;br /&gt;
==Overview==&lt;br /&gt;
== Laboratory Findings == &lt;br /&gt;
&lt;br /&gt;
*Laboratory findings consistent with the diagnosis of [[Cholesterol emboli syndrome]] include&amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;FukumotoTsutsui2003&amp;quot;&amp;gt;{{cite journal|last1=Fukumoto|first1=Yoshihiro|last2=Tsutsui|first2=Hiroyuki|last3=Tsuchihashi|first3=Miyuki|last4=Masumoto|first4=Akihiro|last5=Takeshita|first5=Akira|title=The incidence and risk factors of cholesterol embolization syndrome, a complication of cardiac catheterization: a prospective study|journal=Journal of the American College of Cardiology|volume=42|issue=2|year=2003|pages=211–216|issn=07351097|doi=10.1016/S0735-1097(03)00579-5}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**Tests for [[inflammation]] ([[C-reactive protein]] and the [[erythrocyte sedimentation rate]]) are typically elevated&lt;br /&gt;
**abnormal [[liver enzyme]]s&lt;br /&gt;
**If the kidneys are involved, tests of [[renal function]] (such as [[urea]] and [[creatinine]]) are elevated.&lt;br /&gt;
**The [[complete blood count]] may show particularly high numbers of a type of [[white blood cell]] known as &#039;&#039;[[eosinophil]]s&#039;&#039; (more than 0.5 billion per liter); this occurs in only 60-80% of cases, so normal [[eosinophil]] counts do not rule out the diagnosis.&amp;lt;ref name=&amp;quot;CecioniFassio2007&amp;quot;&amp;gt;{{cite journal|last1=Cecioni|first1=Ilaria|last2=Fassio|first2=Filippo|last3=Gori|first3=Stefano|last4=Giudizi|first4=Maria Grazia|last5=Romagnani|first5=Sergio|last6=Almerigogna|first6=Fabio|title=Eosinophilia in cholesterol atheroembolic disease|journal=Journal of Allergy and Clinical Immunology|volume=120|issue=6|year=2007|pages=1470–1471|issn=00916749|doi=10.1016/j.jaci.2007.07.014}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**Examination of the urine may show [[red blood cell]]s (occasionally in [[urinary casts|casts]] as seen under the microscope) and increased levels of [[protein]]; in a third of the cases with [[kidney]] involvement, [[eosinophils]] can also be detected in the [[urine]].&lt;br /&gt;
**If [[vasculitis]] is suspected, [[complement]] levels may be determined as reduced levels are often encountered in [[vasculitis]][[; complement]] is a group of [[proteins]] that forms part of the innate [[immune system]]. [[Complement]] levels are frequently reduced in [[cholesterol embolism syndrome]], limiting the use of this test in the distinction between [[vasculitis]] and [[cholesterol embolism syndrome]].&amp;lt;ref&amp;gt;{{cite journal |author=Cosio FG, Zager RA, Sharma HM |title=Atheroembolic renal disease causes hypocomplementaemia |journal=Lancet |volume=2 |issue=8447 |pages=118–21 |year=1985 |month=July |pmid=2862317 |doi=10.1016/S0140-6736(85)90225-9}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
* If Organ damage occurs, laboratory findings include&lt;br /&gt;
*:* [[Renal failure]] - increased serum [[creatinine]] and BUN &amp;lt;cite&amp;gt;greenberg&amp;lt;/cite&amp;gt; &lt;br /&gt;
*:* [[Myocardial infarction]] - serum [[creatine kinase]] (CPK) and [[troponin]] elevation &lt;br /&gt;
*:* [[Mesenteric ischemia]] - Bloody (OB+) stool common &lt;br /&gt;
&lt;br /&gt;
=== Biomarker Studies === &lt;br /&gt;
*increased ESR and CRP&lt;br /&gt;
* Peripheral [[eosinophilia]] &amp;lt;cite&amp;gt;moolenaarneth&amp;lt;/cite&amp;gt; &lt;br /&gt;
* [[eosinophiluria]] - usually in patients with cholesterol-renal disease &lt;br /&gt;
* [[Hematuria]]&lt;br /&gt;
* [[proteinuria]]&lt;br /&gt;
* May have [[leukocytosis]] (even &amp;gt;20K/µL) with left shift &lt;br /&gt;
* [[Hypocomplementemia]] is common&lt;br /&gt;
* [[Thrombocytopenia]] due to aggregation and complement activation&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
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[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
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		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_history_and_symptoms&amp;diff=1690043</id>
		<title>Cholesterol emboli syndrome history and symptoms</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_history_and_symptoms&amp;diff=1690043"/>
		<updated>2021-02-14T23:47:04Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
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&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}} {{AE}}{{NN}} &lt;br /&gt;
==Overview==&lt;br /&gt;
Clinical presentation is variable and depends on the organ involved by cholesterol crystals. Due to cholesterol embolization, many organs such as skin, kidneys, heart, gastrointestinal tract, nervous system, eyes, and skeletal muscles can be involved.&lt;br /&gt;
==History==&lt;br /&gt;
*Obtaining the history is the essential for making a diagnosis of [[cholesterol emboli syndrome]]. &amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*A positive history of [[atherosclerosis]] and [[cardiovascular]] interventions such as [[angiography]] is suggestive of [[cholesterol emboli syndrome]]. &amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical presentation is variable and depends on the organ involved by cholesterol crystals.&lt;br /&gt;
==Symptoms==&lt;br /&gt;
*The most common symptoms of [[cholesterol emboli syndrome]] include&amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;Falanga1986&amp;quot;&amp;gt;{{cite journal|last1=Falanga|first1=Vincent|title=The Cutaneous Manifestations of Cholesterol Crystal Embolization|journal=Archives of Dermatology|volume=122|issue=10|year=1986|pages=1194|issn=0003-987X|doi=10.1001/archderm.1986.01660220112024}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;QuinonesSaric2013&amp;quot;&amp;gt;{{cite journal|last1=Quinones|first1=Adriana|last2=Saric|first2=Muhamed|title=The Cholesterol Emboli Syndrome in Atherosclerosis|journal=Current Atherosclerosis Reports|volume=15|issue=4|year=2013|issn=1523-3804|doi=10.1007/s11883-013-0315-y}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;SaricKronzon2011&amp;quot;&amp;gt;{{cite journal|last1=Saric|first1=Muhamed|last2=Kronzon|first2=Itzhak|title=Cholesterol embolization syndrome|journal=Current Opinion in Cardiology|volume=26|issue=6|year=2011|pages=472–479|issn=0268-4705|doi=10.1097/HCO.0b013e32834b7fdd}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**Non-specific symptoms&lt;br /&gt;
***[[Fever]]&lt;br /&gt;
***[[loss of appetite]]&lt;br /&gt;
***[[Fatigue]]&lt;br /&gt;
***[[weight loss]]&lt;br /&gt;
***[[muscle ache]]&lt;br /&gt;
**Cutaneous&lt;br /&gt;
***[[livedo reticularis]]&lt;br /&gt;
***[[Blue toe syndrome]]&lt;br /&gt;
***[[petechiae]] and [[purpura]]&lt;br /&gt;
***[[cyanosis]]&lt;br /&gt;
***[[Gangrene]]&lt;br /&gt;
**Heart&lt;br /&gt;
***[[myocardial infarction]]&lt;br /&gt;
**Kidney&lt;br /&gt;
***[[acute kidney injury]]&lt;br /&gt;
****[[nausea]], [[vomiting]], [[electrolyte]] disturbances&lt;br /&gt;
***[[chronic kidney failure]]&lt;br /&gt;
***[[end stage renal disease]]&lt;br /&gt;
***[[focal segmental glomerulonephritis]]&lt;br /&gt;
**Gastrointestinal&lt;br /&gt;
***[[abdominal pain]]&lt;br /&gt;
***[[nausea]], [[vomiting]]&lt;br /&gt;
***[[diarrhea]]&lt;br /&gt;
***[[GI bleeding]]&lt;br /&gt;
***bowel [[ischemia]]&lt;br /&gt;
***[[pancreatitis]]&lt;br /&gt;
***[[hepatic]] necrosis&lt;br /&gt;
**CNS&lt;br /&gt;
***[[headache]]&lt;br /&gt;
***[[Dizziness]]&lt;br /&gt;
***[[Confusion]]&lt;br /&gt;
***[[Stroke]]&lt;br /&gt;
***[[Paraparesis]]&lt;br /&gt;
***[[Mononeuropathy]]&lt;br /&gt;
**Eye&lt;br /&gt;
***[[eye]] pain&lt;br /&gt;
*** transient loss of vision or [[amaurosis fugax]]&lt;br /&gt;
***[[blurry vision]]&lt;br /&gt;
**lung&lt;br /&gt;
***[[alveolar bleeding]]&lt;br /&gt;
**Muscle&lt;br /&gt;
***[[myositis]]&lt;br /&gt;
***[[Rhabdomyolysis]]&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
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		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_natural_history,_complications_and_prognosis&amp;diff=1689473</id>
		<title>Cholesterol emboli syndrome natural history, complications and prognosis</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_natural_history,_complications_and_prognosis&amp;diff=1689473"/>
		<updated>2021-02-10T14:06:07Z</updated>

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{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}} {{AE}}{{NN}} &lt;br /&gt;
==Overview==&lt;br /&gt;
Common complications of [[Cholesterol emboli syndrome]] include [[atheroembolic]] [[renal disease]], [[acute kidney injury]], [[chronic kidney disease]], [[myocardial infarction]], [[cerebrovascular accident]] [[bowel ischemia]], [[liver failure]], [[end organ damage]] and death. Prognosis is generally poor, and the incidence of mortality among patients with [[Cholesterol emboli syndrome]] is approximately 63-80 %.&lt;br /&gt;
==Natural History, Complications and Prognosis==&lt;br /&gt;
*Common complications of [[Cholesterol emboli syndrome]] include [[atheroembolic]] [[renal disease]], [[acute kidney injury]], [[chronic kidney disease]], [[myocardial infarction]], [[cerebrovascular accident]] [[bowel ischemia]], [[liver failure]], [[end organ damage]] and death. &amp;lt;ref name=&amp;quot;AgrawalZiccardi2018&amp;quot;&amp;gt;{{cite journal|last1=Agrawal|first1=Akanksha|last2=Ziccardi|first2=Mary Rodriguez|last3=Witzke|first3=Christian|last4=Palacios|first4=Igor|last5=Rangaswami|first5=Janani|title=Cholesterol embolization syndrome: An under-recognized entity in cardiovascular interventions|journal=Journal of Interventional Cardiology|volume=31|issue=3|year=2018|pages=407–415|issn=08964327|doi=10.1111/joic.12483}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*Prognosis is generally poor, and the incidence of mortality among patients with [[Cholesterol emboli syndrome]] is approximately 63-80 %.&amp;lt;ref name=&amp;quot;AgrawalZiccardi2018&amp;quot;&amp;gt;{{cite journal|last1=Agrawal|first1=Akanksha|last2=Ziccardi|first2=Mary Rodriguez|last3=Witzke|first3=Christian|last4=Palacios|first4=Igor|last5=Rangaswami|first5=Janani|title=Cholesterol embolization syndrome: An under-recognized entity in cardiovascular interventions|journal=Journal of Interventional Cardiology|volume=31|issue=3|year=2018|pages=407–415|issn=08964327|doi=10.1111/joic.12483}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;FineKapoor2016&amp;quot;&amp;gt;{{cite journal|last1=Fine|first1=Michael J.|last2=Kapoor|first2=Wishwa|last3=Falanga|first3=Vincent|title=Cholesterol Crystal Embolization: A Review of 221 Cases in the English Literature|journal=Angiology|volume=38|issue=10|year=2016|pages=769–784|issn=0003-3197|doi=10.1177/000331978703801007}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
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	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_screening&amp;diff=1689467</id>
		<title>Cholesterol emboli syndrome screening</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_screening&amp;diff=1689467"/>
		<updated>2021-02-10T12:06:40Z</updated>

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{{Cholesterol emboli syndrome}}&lt;br /&gt;
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{{CMG}} {{AE}}{{NN}} &lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[cholesterol emboli syndrome]].&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[cholesterol emboli syndrome]].&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
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		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_risk_factors&amp;diff=1688480</id>
		<title>Cholesterol emboli syndrome risk factors</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_risk_factors&amp;diff=1688480"/>
		<updated>2021-02-03T20:40:15Z</updated>

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__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}} {{AE}}{{NN}} &lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
The most potent risk factor in the development of [[cholesterol emboli syndrome]] is [[atherosclerosis]]. Other risk factors include [[cardiovascular]] interventions such as [[angiography]] and [[cardiovascular]] surgery, [[aortic aneurysm]], [[diabetes mellitus]], [[hypertension]], [[dyslipidemia]], [[smoking]], [[aging]], [[male]] sex, [[anticoagulants]] such as [[warfarin]], [[thrombolytic]] therapy and higher serum [[CRP]] levels. &lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
&lt;br /&gt;
*The most potent risk factor in the development of [[cholesterol emboli syndrome]] is [[atherosclerosis]]. &amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*Other risk factors include&amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;SaklayenGupta2016&amp;quot;&amp;gt;{{cite journal|last1=Saklayen|first1=Mohammad G.|last2=Gupta|first2=Satyendra|last3=Suryaprasad|first3=Agaram|last4=Azmeh|first4=Wayel|last5=Saklayen|first5=Mohammad G.|title=Incidence of Atheroembolic Renal Failure After Coronary Angiography|journal=Angiology|volume=48|issue=7|year=2016|pages=609–613|issn=0003-3197|doi=10.1177/000331979704800707}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;FukumotoTsutsui2003&amp;quot;&amp;gt;{{cite journal|last1=Fukumoto|first1=Yoshihiro|last2=Tsutsui|first2=Hiroyuki|last3=Tsuchihashi|first3=Miyuki|last4=Masumoto|first4=Akihiro|last5=Takeshita|first5=Akira|title=The incidence and risk factors of cholesterol embolization syndrome, a complication of cardiac catheterization: a prospective study|journal=Journal of the American College of Cardiology|volume=42|issue=2|year=2003|pages=211–216|issn=07351097|doi=10.1016/S0735-1097(03)00579-5}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;HymanLandas1987&amp;quot;&amp;gt;{{cite journal|last1=Hyman|first1=Bradley T.|last2=Landas|first2=Steve K.|last3=Ashman|first3=Robert F.|last4=Schelper|first4=Robert L.|last5=Robinson|first5=Robert A.|title=Warfarin-related purple toes syndrome and cholesterol microembolization|journal=The American Journal of Medicine|volume=82|issue=6|year=1987|pages=1233–1237|issn=00029343|doi=10.1016/0002-9343(87)90231-2}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;VarisKuusniemi2010&amp;quot;&amp;gt;{{cite journal|last1=Varis|first1=J.|last2=Kuusniemi|first2=K.|last3=Jarvelainen|first3=H.|title=Cholesterol microembolization syndrome: a complication of anticoagulant therapy|journal=Canadian Medical Association Journal|volume=182|issue=9|year=2010|pages=931–933|issn=0820-3946|doi=10.1503/cmaj.090919}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;HittiWali2008&amp;quot;&amp;gt;{{cite journal|last1=Hitti|first1=Wassim A|last2=Wali|first2=Ravinder K|last3=Weiman|first3=Edward J|last4=Drachenberg|first4=Cinthia|last5=Briglia|first5=Andrew|title=Cholesterol Embolization Syndrome Induced by Thrombolytic Therapy|journal=American Journal of Cardiovascular Drugs|volume=8|issue=1|year=2008|pages=27–34|issn=1175-3277|doi=10.2165/00129784-200808010-00004}}&amp;lt;/ref&amp;gt;:&lt;br /&gt;
**[[cardiovascular]] interventions such as [[angiography]], [[cardiovascular]] surgery&lt;br /&gt;
**[[aortic aneurysm]]&lt;br /&gt;
**[[diabetes mellitus]]&lt;br /&gt;
**[[hypertension]]&lt;br /&gt;
**[[dyslipidemia]]&lt;br /&gt;
**[[smoking]]&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**[[male]] sex&lt;br /&gt;
**[[anticoagulants]] such as [[warfarin]]&lt;br /&gt;
**[[thrombolytic]] therapy&lt;br /&gt;
**higher serum [[CRP]] levels &lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
[[Category:need English review]]&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_causes&amp;diff=1687757</id>
		<title>Cholesterol emboli syndrome causes</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_causes&amp;diff=1687757"/>
		<updated>2021-01-31T20:16:48Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}} {{AE}}{{NN}} &lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
Common causes of [[Cholesterol emboli syndrome]] (CES) include spontaneously due to [[atherosclerosis]] of the large [[arteries]] and iatrogenic secondary to medical interventions such as [[vascular surgery]] or [[angiography]]. Less common causes of CES include intake of [[anticoagulant]]s such as [[warfarin]] or [[thrombolysis|thrombolytic]] medications.&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
*Common causes of [[Cholesterol emboli syndrome]] (CES) include:&lt;br /&gt;
**spontaneously (25%): It usually occurs in patients with severe [[atherosclerosis]] of the large [[arteries]] such as [[aorta]]. &lt;br /&gt;
**Iatrogenic (75%): a complication of medical procedures involving the blood vessels, such as [[vascular surgery]] or [[angiography]]. &lt;br /&gt;
***The incidence of CES after [[coronary catheterization]] is 1.4%. &amp;lt;ref name=&amp;quot;FukumotoTsutsui2003&amp;quot;&amp;gt;{{cite journal|last1=Fukumoto|first1=Yoshihiro|last2=Tsutsui|first2=Hiroyuki|last3=Tsuchihashi|first3=Miyuki|last4=Masumoto|first4=Akihiro|last5=Takeshita|first5=Akira|title=The incidence and risk factors of cholesterol embolization syndrome, a complication of cardiac catheterization: a prospective study|journal=Journal of the American College of Cardiology|volume=42|issue=2|year=2003|pages=211–216|issn=07351097|doi=10.1016/S0735-1097(03)00579-5}}&amp;lt;/ref&amp;gt; &lt;br /&gt;
***But the overall prevalence of CES after [[coronary catheterization]] is 25% to 30%. &amp;lt;ref name=&amp;quot;Ramirez1978&amp;quot;&amp;gt;{{cite journal|last1=Ramirez|first1=German|title=Cholesterol Embolization|journal=Archives of Internal Medicine|volume=138|issue=9|year=1978|pages=1430|issn=0003-9926|doi=10.1001/archinte.1978.03630340096035}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*less Common causes of [[Cholesterol emboli syndrome]] (CES) include:&lt;br /&gt;
** intake of [[anticoagulant]]s such as [[warfarin]] or [[thrombolysis|thrombolytic]] medications such as [[tissue plasminogen activator]]that decrease blood clotting or dissolve blood clots, respectively. They probably lead to [[cholesterol emboli]] by removing blood clots that cover up a damaged [[atherosclerotic]] plaque; cholesterol-rich debris can then enter the [[bloodsteam]]. &amp;lt;ref name=&amp;quot;Feder1961&amp;quot;&amp;gt;{{cite journal|last1=Feder|first1=Walter|title=&amp;quot;Purple Toes&amp;quot;: an Uncommon Sequela of Oral Coumarin Drug Therapy|journal=Annals of Internal Medicine|volume=55|issue=6|year=1961|pages=911|issn=0003-4819|doi=10.7326/0003-4819-55-6-911}}&amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid2507919&amp;quot;&amp;gt;{{cite journal| author=Shapiro LS| title=Cholesterol embolization after treatment with tissue plasminogen activator. | journal=N Engl J Med | year= 1989 | volume= 321 | issue= 18 | pages= 1270 | pmid=2507919 | doi=10.1056/NEJM198911023211816 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=2507919  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
[[Category:needs English]]&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_pathophysiology&amp;diff=1687272</id>
		<title>Cholesterol emboli syndrome pathophysiology</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_pathophysiology&amp;diff=1687272"/>
		<updated>2021-01-29T14:45:01Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}} {{AE}}{{NN}} &lt;br /&gt;
==Overview==&lt;br /&gt;
[[cholesterol emboli syndrome]] (CES) is the result of rupture and release of [[cholesterol]] crystals from [[atherosclerotic]] plaques, produced either spontaneously or [[iatrogenic]] that lead to mechanical obstruction of [[arterioles]] and [[inflammatory]] response activation that cause multiple organ damage.&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[cholesterol emboli syndrome]] (CES) is the result of rupture and release of [[cholesterol]] crystals from [[atherosclerotic]] plaques, produced either spontaneously or as a result of iatrogenesis.&amp;lt;ref name=&amp;quot;Ozkok2016&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=Cholesterol embolization syndrome: report of two cases|journal=Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology|year=2016|issn=10165169|doi=10.5543/tkda.2015.94587}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Cholesterol emboli syndrome]] (CES) is defined as the occlusion of 100-200 µm [[arterioles]] by [[cholesterol]] crystals after their dislodgment from [[atheromatous plaques]], which arised from proximal large [[arteries]] such as [[aorta]].&amp;lt;ref name=&amp;quot;Ozkok2016&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=Cholesterol embolization syndrome: report of two cases|journal=Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology|year=2016|issn=10165169|doi=10.5543/tkda.2015.94587}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*embolization of [[cholesterol crystals]] lead to several damages including&amp;lt;ref name=&amp;quot;Ozkok2016&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=Cholesterol embolization syndrome: report of two cases|journal=Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology|year=2016|issn=10165169|doi=10.5543/tkda.2015.94587}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**Endothelial injury&lt;br /&gt;
**activation of [[complement system]]&lt;br /&gt;
**[[oxidative stress]] injury&lt;br /&gt;
**activation of the [[renin]]–[[angiotensin]]–[[aldosterone]] system (RAAS) due to [[renal arteries]] obstruction and [[hypoperfusion]]&lt;br /&gt;
**[[leukocyte]] infiltration and release of its enzymes which cause [[inflammation]]&lt;br /&gt;
* [[cholesterol emboli]] can involve many organs including [[brain]], [[kidneys]], [[eyes]], [[skin]], [[muscles]], and [[gastrointestinal]] tract. &amp;lt;ref name=&amp;quot;pmid32310551&amp;quot;&amp;gt;{{cite journal | vauthors = Shah N, Nagalli S | title = | journal = | volume = | issue = | pages = | date = | pmid = 32310551 | doi = | url = | issn = }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
[[Category: Needs English Review]]&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_pathophysiology&amp;diff=1687271</id>
		<title>Cholesterol emboli syndrome pathophysiology</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_pathophysiology&amp;diff=1687271"/>
		<updated>2021-01-29T14:42:55Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}} {{AE}}{{NN}} &lt;br /&gt;
==Overview==&lt;br /&gt;
[[cholesterol emboli syndrome]] (CES) is the result of rupture and release of [[cholesterol]] crystals from [[atherosclerotic plaques]], produced either spontaneously or [[iatrogenic]] that lead to mechanical obstruction of [[arterioles]] and [[inflammatory]] response activation that cause multiple organ damage.&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[cholesterol emboli syndrome]] (CES) is the result of rupture and release of [[cholesterol]] crystals from [[atherosclerotic plaques]], produced either spontaneously or as a result of iatrogenesis.&amp;lt;ref name=&amp;quot;Ozkok2016&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=Cholesterol embolization syndrome: report of two cases|journal=Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology|year=2016|issn=10165169|doi=10.5543/tkda.2015.94587}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*Cholesterol emboli syndrome (CES) is defined as the occlusion of 100-200 µm [[arterioles]] by [[cholesterol]] crystals after their dislodgment from [[atheromatous plaques]], which arised from proximal large [[arteries]] such as [[aorta]].&amp;lt;ref name=&amp;quot;Ozkok2016&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=Cholesterol embolization syndrome: report of two cases|journal=Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology|year=2016|issn=10165169|doi=10.5543/tkda.2015.94587}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*embolization of [[cholesterol crystals]] lead to several damages including&amp;lt;ref name=&amp;quot;Ozkok2016&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=Cholesterol embolization syndrome: report of two cases|journal=Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology|year=2016|issn=10165169|doi=10.5543/tkda.2015.94587}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**Endothelial injury&lt;br /&gt;
**activation of [[complement system]]&lt;br /&gt;
**[[oxidative stress]] injury&lt;br /&gt;
**activation of the [[renin]]–[[angiotensin]]–[[aldosterone]] system (RAAS) due to [[renal arteries]] obstruction and [[hypoperfusion]]&lt;br /&gt;
**[[leukocyte]] infiltration and release of its enzymes which cause [[inflammation]]&lt;br /&gt;
* [[cholesterol emboli]] can involve many organs including [[brain]], [[kidneys]], [[eyes]], [[skin]], [[muscles]], and [[gastrointestinal]] tract. &amp;lt;ref name=&amp;quot;pmid32310551&amp;quot;&amp;gt;{{cite journal | vauthors = Shah N, Nagalli S | title = | journal = | volume = | issue = | pages = | date = | pmid = 32310551 | doi = | url = | issn = }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
[[Category: Needs English Review]]&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_pathophysiology&amp;diff=1687269</id>
		<title>Cholesterol emboli syndrome pathophysiology</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_pathophysiology&amp;diff=1687269"/>
		<updated>2021-01-29T14:33:22Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}} {{AE}}{{NN}} &lt;br /&gt;
==Overview==&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[cholesterol emboli syndrome]] is the result of rupture and release of [[cholesterol]] crystals from [[atherosclerotic plaques]], produced either spontaneously or as a result of iatrogenesis, ref name=&amp;quot;Ozkok2016&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=Cholesterol embolization syndrome: report of two cases|journal=Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology|year=2016|issn=10165169|doi=10.5543/tkda.2015.94587}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;Ozkok2019&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=&amp;lt;p&amp;gt;Cholesterol-embolization syndrome: current perspectives&amp;lt;/p&amp;gt;|journal=Vascular Health and Risk Management|volume=Volume 15|year=2019|pages=209–220|issn=1178-2048|doi=10.2147/VHRM.S175150}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*Cholesterol emboli syndrome (CES) is defined as the occlusion of 100-200 µm [[arterioles]] by [[cholesterol]] crystals after their dislodgment from [[atheromatous plaques]], which arised from proximal large [[arteries]] such as [[aorta]].&amp;lt;ref name=&amp;quot;Ozkok2016&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=Cholesterol embolization syndrome: report of two cases|journal=Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology|year=2016|issn=10165169|doi=10.5543/tkda.2015.94587}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*embolization of [[cholesterol crystals]] lead to several damages including&amp;lt;ref name=&amp;quot;Ozkok2016&amp;quot;&amp;gt;{{cite journal|last1=Ozkok|first1=Abdullah|title=Cholesterol embolization syndrome: report of two cases|journal=Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology|year=2016|issn=10165169|doi=10.5543/tkda.2015.94587}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**Endothelial injury&lt;br /&gt;
**activation of [[complement system]]&lt;br /&gt;
**[[oxidative stress]] injury&lt;br /&gt;
**activation of the [[renin]]–[[angiotensin]]–[[aldosterone]] system (RAAS) due to [[renal arteries]] obstruction and [[hypoperfusion]]&lt;br /&gt;
**[[leukocyte]] infiltration and release of its enzymes which cause [[inflammation]]&lt;br /&gt;
* [[cholesterol emboli]] can involve many organs including [[brain]], [[kidneys]], [[eyes]], [[skin]], [[muscles]], and [[gastrointestinal]] tract. &amp;lt;ref name=&amp;quot;pmid32310551&amp;quot;&amp;gt;{{cite journal | vauthors = Shah N, Nagalli S | title = | journal = | volume = | issue = | pages = | date = | pmid = 32310551 | doi = | url = | issn = }}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_historical_perspective&amp;diff=1680579</id>
		<title>Cholesterol emboli syndrome historical perspective</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_historical_perspective&amp;diff=1680579"/>
		<updated>2020-12-28T04:26:40Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Cholesterol emboli syndrome (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{CMG}}; {{AE}} {{NN}}&amp;lt;br&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
[[Cholesterol emboli]] was first described by a Danish pathophysiologist called Peter Ludvig Panum in 1862. The first case series of [[Arterial Occlusions]] due to [[Emboli]] were reported from 267 autopsies in the New York Hospital by Curtis M. Flory in 1945. The [[cholesterol]] crystals were first identified by polarized light in 1956. [[atheromatous]] [[embolization]] following [[vascular]] surgery was first diagnosed by Thurlbeck and Castleman in 1957. The [[cholesterol emboli]] in the [[retinal]] [[arterioles]] was first described by an ophthalmologist called Dr Robert Hollenhorst in 1961, which is known as Hollenhorst plaques. In 1961, first cases of [[blue toe syndrome]], described as [[painful toes]], following treatment with oral [[anticoagulation]] were reported by Feder and Auerbach. But the term of [[blue toe syndrome]] was first used in 1976. The association between [[aortic plaque]] on [[TEE]] and development of [[emboli]] was reported in 1990.&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
&lt;br /&gt;
*[[Cholesterol emboli]] was first described by a Danish pathophysiologist called Peter Ludvig Panum in 1862. &amp;lt;ref name=&amp;quot;Panum1862&amp;quot;&amp;gt;{{cite journal|last1=Panum|first1=P. L.|title=Experimentelle Beiträge zur Lehre von der Embolie|journal=Virchows Archiv|volume=25|issue=3-4|year=1862|pages=308–338|issn=0945-6317|doi=10.1007/BF01879595}}&amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;KronzonSaric2010&amp;quot;&amp;gt;{{cite journal|last1=Kronzon|first1=Itzhak|last2=Saric|first2=Muhamed|title=Cholesterol Embolization Syndrome|journal=Circulation|volume=122|issue=6|year=2010|pages=631–641|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.109.886465}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
* In 1945, the first case series of [[Arterial Occlusions]] due to [[Emboli]] were reported from 267 autopsies in the New York Hospital by Curtis M. Flory. &amp;lt;ref name=&amp;quot;pmid19970827&amp;quot;&amp;gt;{{cite journal| author=Flory CM| title=Arterial Occlusions Produced by Emboli from Eroded Aortic Atheromatous Plaques. | journal=Am J Pathol | year= 1945 | volume= 21 | issue= 3 | pages= 549-65 | pmid=19970827 | doi= | pmc=1934118 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19970827  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;KronzonSaric2010&amp;quot;&amp;gt;{{cite journal|last1=Kronzon|first1=Itzhak|last2=Saric|first2=Muhamed|title=Cholesterol Embolization Syndrome|journal=Circulation|volume=122|issue=6|year=2010|pages=631–641|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.109.886465}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*The [[cholesterol]] crystals were first identified by polarized light in 1956. &amp;lt;ref name=&amp;quot;KronzonSaric2010&amp;quot;&amp;gt;{{cite journal|last1=Kronzon|first1=Itzhak|last2=Saric|first2=Muhamed|title=Cholesterol Embolization Syndrome|journal=Circulation|volume=122|issue=6|year=2010|pages=631–641|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.109.886465}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[atheromatous]] [[embolization]] following [[vascular]] surgery was first diagnosed by Thurlbeck and Castleman in 1957. &amp;lt;ref name=&amp;quot;KronzonSaric2010&amp;quot;&amp;gt;{{cite journal|last1=Kronzon|first1=Itzhak|last2=Saric|first2=Muhamed|title=Cholesterol Embolization Syndrome|journal=Circulation|volume=122|issue=6|year=2010|pages=631–641|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.109.886465}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*The [[cholesterol emboli]] in the [[retinal]] [[arterioles]] was first described by an ophthalmologist called Dr Robert Hollenhorst in 1961, which is known as Hollenhorst plaques. &amp;lt;ref name=&amp;quot;Hollenhorst1961&amp;quot;&amp;gt;{{cite journal|last1=Hollenhorst|first1=Robert W.|title=Significance of Bright Plaques in the Retinal Arterioles|journal=JAMA|volume=178|issue=1|year=1961|pages=23|issn=0098-7484|doi=10.1001/jama.1961.03040400025005}}&amp;lt;/ref&amp;gt; &lt;br /&gt;
*In 1961, first cases of [[blue toe syndrome]] described as [[painful toes]] following treatment with oral [[anticoagulation]] were reported by Feder and Auerbach. &amp;lt;ref name=&amp;quot;Feder1961&amp;quot;&amp;gt;{{cite journal|last1=Feder|first1=Walter|title=&amp;quot;Purple Toes&amp;quot;: an Uncommon Sequela of Oral Coumarin Drug Therapy|journal=Annals of Internal Medicine|volume=55|issue=6|year=1961|pages=911|issn=0003-4819|doi=10.7326/0003-4819-55-6-911}}&amp;lt;/ref&amp;gt;But the term of [[blue toe syndrome]] was first used in 1976. &amp;lt;ref name=&amp;quot;Karmody1976&amp;quot;&amp;gt;{{cite journal|last1=Karmody|first1=Allastair M.|title=&amp;quot;Blue Toe&amp;quot; Syndrome|journal=Archives of Surgery|volume=111|issue=11|year=1976|pages=1263|issn=0004-0010|doi=10.1001/archsurg.1976.01360290097015}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*In 1990, the association between [[aortic plaque]] on [[TEE]] and development of [[emboli]] was first reported. &amp;lt;ref name=&amp;quot;KronzonSaric2010&amp;quot;&amp;gt;{{cite journal|last1=Kronzon|first1=Itzhak|last2=Saric|first2=Muhamed|title=Cholesterol Embolization Syndrome|journal=Circulation|volume=122|issue=6|year=2010|pages=631–641|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.109.886465}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Embolism]]&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_historical_perspective&amp;diff=1680578</id>
		<title>Cholesterol emboli syndrome historical perspective</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Cholesterol_emboli_syndrome_historical_perspective&amp;diff=1680578"/>
		<updated>2020-12-28T04:26:01Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Historical Perspective */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Cholesterol emboli syndrome}}&lt;br /&gt;
{{CMG}}&lt;br /&gt;
==Overview==&lt;br /&gt;
__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Cholesterol emboli syndrome (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{CMG}}; {{AE}} {{NN}}&amp;lt;br&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
[[Cholesterol emboli]] was first described by a Danish pathophysiologist called Peter Ludvig Panum in 1862. The first case series of [[Arterial Occlusions]] due to [[Emboli]] were reported from 267 autopsies in the New York Hospital by Curtis M. Flory in 1945. The [[cholesterol]] crystals were first identified by polarized light in 1956. [[atheromatous]] [[embolization]] following [[vascular]] surgery was first diagnosed by Thurlbeck and Castleman in 1957. The [[cholesterol emboli]] in the [[retinal]] [[arterioles]] was first described by an ophthalmologist called Dr Robert Hollenhorst in 1961, which is known as Hollenhorst plaques. In 1961, first cases of [[blue toe syndrome]], described as [[painful toes]], following treatment with oral [[anticoagulation]] were reported by Feder and Auerbach. But the term of [[blue toe syndrome]] was first used in 1976. The association between [[aortic plaque]] on [[TEE]] and development of [[emboli]] was reported in 1990.&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
&lt;br /&gt;
*[[Cholesterol emboli]] was first described by a Danish pathophysiologist called Peter Ludvig Panum in 1862. &amp;lt;ref name=&amp;quot;Panum1862&amp;quot;&amp;gt;{{cite journal|last1=Panum|first1=P. L.|title=Experimentelle Beiträge zur Lehre von der Embolie|journal=Virchows Archiv|volume=25|issue=3-4|year=1862|pages=308–338|issn=0945-6317|doi=10.1007/BF01879595}}&amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;KronzonSaric2010&amp;quot;&amp;gt;{{cite journal|last1=Kronzon|first1=Itzhak|last2=Saric|first2=Muhamed|title=Cholesterol Embolization Syndrome|journal=Circulation|volume=122|issue=6|year=2010|pages=631–641|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.109.886465}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
* In 1945, the first case series of [[Arterial Occlusions]] due to [[Emboli]] were reported from 267 autopsies in the New York Hospital by Curtis M. Flory. &amp;lt;ref name=&amp;quot;pmid19970827&amp;quot;&amp;gt;{{cite journal| author=Flory CM| title=Arterial Occlusions Produced by Emboli from Eroded Aortic Atheromatous Plaques. | journal=Am J Pathol | year= 1945 | volume= 21 | issue= 3 | pages= 549-65 | pmid=19970827 | doi= | pmc=1934118 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19970827  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;KronzonSaric2010&amp;quot;&amp;gt;{{cite journal|last1=Kronzon|first1=Itzhak|last2=Saric|first2=Muhamed|title=Cholesterol Embolization Syndrome|journal=Circulation|volume=122|issue=6|year=2010|pages=631–641|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.109.886465}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*The [[cholesterol]] crystals were first identified by polarized light in 1956. &amp;lt;ref name=&amp;quot;KronzonSaric2010&amp;quot;&amp;gt;{{cite journal|last1=Kronzon|first1=Itzhak|last2=Saric|first2=Muhamed|title=Cholesterol Embolization Syndrome|journal=Circulation|volume=122|issue=6|year=2010|pages=631–641|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.109.886465}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[atheromatous]] [[embolization]] following [[vascular]] surgery was first diagnosed by Thurlbeck and Castleman in 1957. &amp;lt;ref name=&amp;quot;KronzonSaric2010&amp;quot;&amp;gt;{{cite journal|last1=Kronzon|first1=Itzhak|last2=Saric|first2=Muhamed|title=Cholesterol Embolization Syndrome|journal=Circulation|volume=122|issue=6|year=2010|pages=631–641|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.109.886465}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*The [[cholesterol emboli]] in the [[retinal]] [[arterioles]] was first described by an ophthalmologist called Dr Robert Hollenhorst in 1961, which is known as Hollenhorst plaques. &amp;lt;ref name=&amp;quot;Hollenhorst1961&amp;quot;&amp;gt;{{cite journal|last1=Hollenhorst|first1=Robert W.|title=Significance of Bright Plaques in the Retinal Arterioles|journal=JAMA|volume=178|issue=1|year=1961|pages=23|issn=0098-7484|doi=10.1001/jama.1961.03040400025005}}&amp;lt;/ref&amp;gt; &lt;br /&gt;
*In 1961, first cases of [[blue toe syndrome]] described as [[painful toes]] following treatment with oral [[anticoagulation]] were reported by Feder and Auerbach. &amp;lt;ref name=&amp;quot;Feder1961&amp;quot;&amp;gt;{{cite journal|last1=Feder|first1=Walter|title=&amp;quot;Purple Toes&amp;quot;: an Uncommon Sequela of Oral Coumarin Drug Therapy|journal=Annals of Internal Medicine|volume=55|issue=6|year=1961|pages=911|issn=0003-4819|doi=10.7326/0003-4819-55-6-911}}&amp;lt;/ref&amp;gt;But the term of [[blue toe syndrome]] was first used in 1976. &amp;lt;ref name=&amp;quot;Karmody1976&amp;quot;&amp;gt;{{cite journal|last1=Karmody|first1=Allastair M.|title=&amp;quot;Blue Toe&amp;quot; Syndrome|journal=Archives of Surgery|volume=111|issue=11|year=1976|pages=1263|issn=0004-0010|doi=10.1001/archsurg.1976.01360290097015}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*In 1990, the association between [[aortic plaque]] on [[TEE]] and development of [[emboli]] was first reported. &amp;lt;ref name=&amp;quot;KronzonSaric2010&amp;quot;&amp;gt;{{cite journal|last1=Kronzon|first1=Itzhak|last2=Saric|first2=Muhamed|title=Cholesterol Embolization Syndrome|journal=Circulation|volume=122|issue=6|year=2010|pages=631–641|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.109.886465}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Embolism]]&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Cardiology]]&lt;br /&gt;
[[Category:Nephrology]]&lt;br /&gt;
[[Category:Vascular surgery]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
&lt;br /&gt;
{{WikiDoc Help Menu}}&lt;br /&gt;
{{WikiDoc Sources}}&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1678347</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1678347"/>
		<updated>2020-12-12T22:48:21Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}} {{NN}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
&lt;br /&gt;
*Laboratory tests that should be helpful for the diagnosis of [[nocturia]] include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urine analysis]] with [[urine culture]] to rule out [[urinary tract infection]]&lt;br /&gt;
**serum [[electrolytes]]&lt;br /&gt;
**[[renal]] function tests such as [[BUN]], [[creatinine]], [[GFR]]&lt;br /&gt;
**serum glucose level and HbA1c to rule out [[diabetes mellitus]]&lt;br /&gt;
**[[lipid]] profile&lt;br /&gt;
**PSA level to rule out [[prostate cancer]] and [[BPH]]&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===Ultrasound===&lt;br /&gt;
&lt;br /&gt;
*ultrasound may be helpful in the diagnosis of [[nocturia]] associated conditions. Ultrasound can measure [[postvoid residual volume]] and [[bladder]] wall thickness. &amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20127835&amp;quot;&amp;gt;{{cite journal| author=Panayi DC, Tekkis P, Fernando R, Hendricken C, Khullar V| title=Ultrasound measurement of bladder wall thickness is associated with the overactive bladder syndrome. | journal=Neurourol Urodyn | year= 2010 | volume= 29 | issue= 7 | pages= 1295-8 | pmid=20127835 | doi=10.1002/nau.20871 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20127835  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
&lt;br /&gt;
*There are no CT scan findings associated with [[nocturia]]. However, a CT scan may be helpful in the diagnosis of [[bladder]], [[prostate]] and [[urinary tracts]] abnormalities.&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
&lt;br /&gt;
*[[Cystoscopy]] may be helpful in the diagnosis of [[bladder]] abnormalities that cause [[nocturia]]. &amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
=== Treatment===&lt;br /&gt;
* Treatment options for [[nocturia]] depend on the underlying causes.&lt;br /&gt;
*Behavioral modification includes &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** limiting fluid intake in the evening&lt;br /&gt;
**avoiding alcohol, coffee and tea &lt;br /&gt;
**treating underlying conditions such as chronic [[constipation]], [[diabetes mellitus]], [[diabetes insipidus]]&lt;br /&gt;
**elevation of the lower limbs in the evening &lt;br /&gt;
**avoiding [[diuretics]] intake in the evening and night&lt;br /&gt;
**[[physical exercise]]&lt;br /&gt;
* Pharmacologic medical therapies for [[nocturia]] include &lt;br /&gt;
**[[desmopressin]] ([[arginine]] [[vasopressin]]) &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
***It decreases urine volume through [[vasopressin]] V2 receptors, which leads to increase water reabsorption in [[renal tubules]].&lt;br /&gt;
*** It is the preferred drug for the treatment of [[nocturia]] due to nocturnal polyuria according to the European Association of Urology (EAU) recommendation. &amp;lt;ref name=&amp;quot;pmid23541338&amp;quot;&amp;gt;{{cite journal| author=Oelke M, Bachmann A, Descazeaud A, Emberton M, Gravas S, Michel MC | display-authors=etal| title=EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. | journal=Eur Urol | year= 2013 | volume= 64 | issue= 1 | pages= 118-40 | pmid=23541338 | doi=10.1016/j.eururo.2013.03.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23541338  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** α-blockers&lt;br /&gt;
** antimuscarinics&lt;br /&gt;
**phosphodiesterase type 5 inhibitors&lt;br /&gt;
**Botulinum toxin&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
&lt;br /&gt;
*Effective measures for the primary prevention of [[nocturia]] include [[lifestyle]] modifications such as &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**reducing intake of [[fluid]], [[caffeine]], [[alcohol]], [[diuretics]] in the evening and night&lt;br /&gt;
**less [[salt]] intake&lt;br /&gt;
**take naps in the afternoon&lt;br /&gt;
**[[weight loss]] in obese and overweight individuals&lt;br /&gt;
**[[urination]] before going to bed&lt;br /&gt;
**using compression stocks or elevating legs to reduce edema&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677514</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677514"/>
		<updated>2020-12-09T10:40:20Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* MRI */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
&lt;br /&gt;
*Laboratory tests that should be helpful for the diagnosis of [[nocturia]] include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urine analysis]] with [[urine culture]] to rule out [[urinary tract infection]]&lt;br /&gt;
**serum [[electrolytes]]&lt;br /&gt;
**[[renal]] function tests such as [[BUN]], [[creatinine]], [[GFR]]&lt;br /&gt;
**serum glucose level and HbA1c to rule out [[diabetes mellitus]]&lt;br /&gt;
**[[lipid]] profile&lt;br /&gt;
**PSA level to rule out [[prostate cancer]] and [[BPH]]&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===Ultrasound===&lt;br /&gt;
&lt;br /&gt;
*ultrasound may be helpful in the diagnosis of [[nocturia]] associated conditions. Ultrasound can measure [[postvoid residual volume]] and [[bladder]] wall thickness. &amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20127835&amp;quot;&amp;gt;{{cite journal| author=Panayi DC, Tekkis P, Fernando R, Hendricken C, Khullar V| title=Ultrasound measurement of bladder wall thickness is associated with the overactive bladder syndrome. | journal=Neurourol Urodyn | year= 2010 | volume= 29 | issue= 7 | pages= 1295-8 | pmid=20127835 | doi=10.1002/nau.20871 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20127835  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
&lt;br /&gt;
*There are no CT scan findings associated with [[nocturia]]. However, a CT scan may be helpful in the diagnosis of [[bladder]], [[prostate]] and [[urinary tracts]] abnormalities.&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
&lt;br /&gt;
*[[Cystoscopy]] may be helpful in the diagnosis of [[bladder]] abnormalities that cause [[nocturia]]. &amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
=== Treatment===&lt;br /&gt;
* Treatment options for [[nocturia]] depend on the underlying causes.&lt;br /&gt;
*Behavioral modification includes &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** limiting fluid intake in the evening&lt;br /&gt;
**avoiding alcohol, coffee and tea &lt;br /&gt;
**treating underlying conditions such as chronic [[constipation]], [[diabetes mellitus]], [[diabetes insipidus]]&lt;br /&gt;
**elevation of the lower limbs in the evening &lt;br /&gt;
**avoiding [[diuretics]] intake in the evening and night&lt;br /&gt;
**[[physical exercise]]&lt;br /&gt;
* Pharmacologic medical therapies for [[nocturia]] include &lt;br /&gt;
**[[desmopressin]] ([[arginine]] [[vasopressin]]) &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
***It decreases urine volume through [[vasopressin]] V2 receptors, which leads to increase water reabsorption in [[renal tubules]].&lt;br /&gt;
*** It is the preferred drug for the treatment of [[nocturia]] due to nocturnal polyuria according to the European Association of Urology (EAU) recommendation. &amp;lt;ref name=&amp;quot;pmid23541338&amp;quot;&amp;gt;{{cite journal| author=Oelke M, Bachmann A, Descazeaud A, Emberton M, Gravas S, Michel MC | display-authors=etal| title=EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. | journal=Eur Urol | year= 2013 | volume= 64 | issue= 1 | pages= 118-40 | pmid=23541338 | doi=10.1016/j.eururo.2013.03.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23541338  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** α-blockers&lt;br /&gt;
** antimuscarinics&lt;br /&gt;
**phosphodiesterase type 5 inhibitors&lt;br /&gt;
**Botulinum toxin&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
&lt;br /&gt;
*Effective measures for the primary prevention of [[nocturia]] include [[lifestyle]] modifications such as &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**reducing intake of [[fluid]], [[caffeine]], [[alcohol]], [[diuretics]] in the evening and night&lt;br /&gt;
**less [[salt]] intake&lt;br /&gt;
**take naps in the afternoon&lt;br /&gt;
**[[weight loss]] in obese and overweight individuals&lt;br /&gt;
**[[urination]] before going to bed&lt;br /&gt;
**using compression stocks or elevating legs to reduce edema&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677513</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677513"/>
		<updated>2020-12-09T10:39:45Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* X-ray */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
&lt;br /&gt;
*Laboratory tests that should be helpful for the diagnosis of [[nocturia]] include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urine analysis]] with [[urine culture]] to rule out [[urinary tract infection]]&lt;br /&gt;
**serum [[electrolytes]]&lt;br /&gt;
**[[renal]] function tests such as [[BUN]], [[creatinine]], [[GFR]]&lt;br /&gt;
**serum glucose level and HbA1c to rule out [[diabetes mellitus]]&lt;br /&gt;
**[[lipid]] profile&lt;br /&gt;
**PSA level to rule out [[prostate cancer]] and [[BPH]]&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===Ultrasound===&lt;br /&gt;
&lt;br /&gt;
*ultrasound may be helpful in the diagnosis of [[nocturia]] associated conditions. Ultrasound can measure [[postvoid residual volume]] and [[bladder]] wall thickness. &amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20127835&amp;quot;&amp;gt;{{cite journal| author=Panayi DC, Tekkis P, Fernando R, Hendricken C, Khullar V| title=Ultrasound measurement of bladder wall thickness is associated with the overactive bladder syndrome. | journal=Neurourol Urodyn | year= 2010 | volume= 29 | issue= 7 | pages= 1295-8 | pmid=20127835 | doi=10.1002/nau.20871 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20127835  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
&lt;br /&gt;
*There are no CT scan findings associated with [[nocturia]]. However, a CT scan may be helpful in the diagnosis of [[bladder]], [[prostate]] and [[urinary tracts]] abnormalities.&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
&lt;br /&gt;
*[[Cystoscopy]] may be helpful in the diagnosis of [[bladder]] abnormalities that cause [[nocturia]]. &amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
=== Treatment===&lt;br /&gt;
* Treatment options for [[nocturia]] depend on the underlying causes.&lt;br /&gt;
*Behavioral modification includes &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** limiting fluid intake in the evening&lt;br /&gt;
**avoiding alcohol, coffee and tea &lt;br /&gt;
**treating underlying conditions such as chronic [[constipation]], [[diabetes mellitus]], [[diabetes insipidus]]&lt;br /&gt;
**elevation of the lower limbs in the evening &lt;br /&gt;
**avoiding [[diuretics]] intake in the evening and night&lt;br /&gt;
**[[physical exercise]]&lt;br /&gt;
* Pharmacologic medical therapies for [[nocturia]] include &lt;br /&gt;
**[[desmopressin]] ([[arginine]] [[vasopressin]]) &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
***It decreases urine volume through [[vasopressin]] V2 receptors, which leads to increase water reabsorption in [[renal tubules]].&lt;br /&gt;
*** It is the preferred drug for the treatment of [[nocturia]] due to nocturnal polyuria according to the European Association of Urology (EAU) recommendation. &amp;lt;ref name=&amp;quot;pmid23541338&amp;quot;&amp;gt;{{cite journal| author=Oelke M, Bachmann A, Descazeaud A, Emberton M, Gravas S, Michel MC | display-authors=etal| title=EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. | journal=Eur Urol | year= 2013 | volume= 64 | issue= 1 | pages= 118-40 | pmid=23541338 | doi=10.1016/j.eururo.2013.03.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23541338  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** α-blockers&lt;br /&gt;
** antimuscarinics&lt;br /&gt;
**phosphodiesterase type 5 inhibitors&lt;br /&gt;
**Botulinum toxin&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
&lt;br /&gt;
*Effective measures for the primary prevention of [[nocturia]] include [[lifestyle]] modifications such as &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**reducing intake of [[fluid]], [[caffeine]], [[alcohol]], [[diuretics]] in the evening and night&lt;br /&gt;
**less [[salt]] intake&lt;br /&gt;
**take naps in the afternoon&lt;br /&gt;
**[[weight loss]] in obese and overweight individuals&lt;br /&gt;
**[[urination]] before going to bed&lt;br /&gt;
**using compression stocks or elevating legs to reduce edema&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677512</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677512"/>
		<updated>2020-12-09T10:38:43Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Echocardiography or Ultrasound */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
&lt;br /&gt;
*Laboratory tests that should be helpful for the diagnosis of [[nocturia]] include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urine analysis]] with [[urine culture]] to rule out [[urinary tract infection]]&lt;br /&gt;
**serum [[electrolytes]]&lt;br /&gt;
**[[renal]] function tests such as [[BUN]], [[creatinine]], [[GFR]]&lt;br /&gt;
**serum glucose level and HbA1c to rule out [[diabetes mellitus]]&lt;br /&gt;
**[[lipid]] profile&lt;br /&gt;
**PSA level to rule out [[prostate cancer]] and [[BPH]]&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Ultrasound===&lt;br /&gt;
&lt;br /&gt;
*ultrasound may be helpful in the diagnosis of [[nocturia]] associated conditions. Ultrasound can measure [[postvoid residual volume]] and [[bladder]] wall thickness. &amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20127835&amp;quot;&amp;gt;{{cite journal| author=Panayi DC, Tekkis P, Fernando R, Hendricken C, Khullar V| title=Ultrasound measurement of bladder wall thickness is associated with the overactive bladder syndrome. | journal=Neurourol Urodyn | year= 2010 | volume= 29 | issue= 7 | pages= 1295-8 | pmid=20127835 | doi=10.1002/nau.20871 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20127835  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
&lt;br /&gt;
*There are no CT scan findings associated with [[nocturia]]. However, a CT scan may be helpful in the diagnosis of [[bladder]], [[prostate]] and [[urinary tracts]] abnormalities.&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
&lt;br /&gt;
*[[Cystoscopy]] may be helpful in the diagnosis of [[bladder]] abnormalities that cause [[nocturia]]. &amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
=== Treatment===&lt;br /&gt;
* Treatment options for [[nocturia]] depend on the underlying causes.&lt;br /&gt;
*Behavioral modification includes &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** limiting fluid intake in the evening&lt;br /&gt;
**avoiding alcohol, coffee and tea &lt;br /&gt;
**treating underlying conditions such as chronic [[constipation]], [[diabetes mellitus]], [[diabetes insipidus]]&lt;br /&gt;
**elevation of the lower limbs in the evening &lt;br /&gt;
**avoiding [[diuretics]] intake in the evening and night&lt;br /&gt;
**[[physical exercise]]&lt;br /&gt;
* Pharmacologic medical therapies for [[nocturia]] include &lt;br /&gt;
**[[desmopressin]] ([[arginine]] [[vasopressin]]) &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
***It decreases urine volume through [[vasopressin]] V2 receptors, which leads to increase water reabsorption in [[renal tubules]].&lt;br /&gt;
*** It is the preferred drug for the treatment of [[nocturia]] due to nocturnal polyuria according to the European Association of Urology (EAU) recommendation. &amp;lt;ref name=&amp;quot;pmid23541338&amp;quot;&amp;gt;{{cite journal| author=Oelke M, Bachmann A, Descazeaud A, Emberton M, Gravas S, Michel MC | display-authors=etal| title=EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. | journal=Eur Urol | year= 2013 | volume= 64 | issue= 1 | pages= 118-40 | pmid=23541338 | doi=10.1016/j.eururo.2013.03.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23541338  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** α-blockers&lt;br /&gt;
** antimuscarinics&lt;br /&gt;
**phosphodiesterase type 5 inhibitors&lt;br /&gt;
**Botulinum toxin&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
&lt;br /&gt;
*Effective measures for the primary prevention of [[nocturia]] include [[lifestyle]] modifications such as &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**reducing intake of [[fluid]], [[caffeine]], [[alcohol]], [[diuretics]] in the evening and night&lt;br /&gt;
**less [[salt]] intake&lt;br /&gt;
**take naps in the afternoon&lt;br /&gt;
**[[weight loss]] in obese and overweight individuals&lt;br /&gt;
**[[urination]] before going to bed&lt;br /&gt;
**using compression stocks or elevating legs to reduce edema&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677511</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677511"/>
		<updated>2020-12-09T10:29:14Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* CT scan */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
&lt;br /&gt;
*Laboratory tests that should be helpful for the diagnosis of [[nocturia]] include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urine analysis]] with [[urine culture]] to rule out [[urinary tract infection]]&lt;br /&gt;
**serum [[electrolytes]]&lt;br /&gt;
**[[renal]] function tests such as [[BUN]], [[creatinine]], [[GFR]]&lt;br /&gt;
**serum glucose level and HbA1c to rule out [[diabetes mellitus]]&lt;br /&gt;
**[[lipid]] profile&lt;br /&gt;
**PSA level to rule out [[prostate cancer]] and [[BPH]]&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
&lt;br /&gt;
*There are no CT scan findings associated with [[nocturia]]. However, a CT scan may be helpful in the diagnosis of [[bladder]], [[prostate]] and [[urinary tracts]] abnormalities.&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
&lt;br /&gt;
*[[Cystoscopy]] may be helpful in the diagnosis of [[bladder]] abnormalities that cause [[nocturia]]. &amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
=== Treatment===&lt;br /&gt;
* Treatment options for [[nocturia]] depend on the underlying causes.&lt;br /&gt;
*Behavioral modification includes &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** limiting fluid intake in the evening&lt;br /&gt;
**avoiding alcohol, coffee and tea &lt;br /&gt;
**treating underlying conditions such as chronic [[constipation]], [[diabetes mellitus]], [[diabetes insipidus]]&lt;br /&gt;
**elevation of the lower limbs in the evening &lt;br /&gt;
**avoiding [[diuretics]] intake in the evening and night&lt;br /&gt;
**[[physical exercise]]&lt;br /&gt;
* Pharmacologic medical therapies for [[nocturia]] include &lt;br /&gt;
**[[desmopressin]] ([[arginine]] [[vasopressin]]) &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
***It decreases urine volume through [[vasopressin]] V2 receptors, which leads to increase water reabsorption in [[renal tubules]].&lt;br /&gt;
*** It is the preferred drug for the treatment of [[nocturia]] due to nocturnal polyuria according to the European Association of Urology (EAU) recommendation. &amp;lt;ref name=&amp;quot;pmid23541338&amp;quot;&amp;gt;{{cite journal| author=Oelke M, Bachmann A, Descazeaud A, Emberton M, Gravas S, Michel MC | display-authors=etal| title=EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. | journal=Eur Urol | year= 2013 | volume= 64 | issue= 1 | pages= 118-40 | pmid=23541338 | doi=10.1016/j.eururo.2013.03.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23541338  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** α-blockers&lt;br /&gt;
** antimuscarinics&lt;br /&gt;
**phosphodiesterase type 5 inhibitors&lt;br /&gt;
**Botulinum toxin&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
&lt;br /&gt;
*Effective measures for the primary prevention of [[nocturia]] include [[lifestyle]] modifications such as &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**reducing intake of [[fluid]], [[caffeine]], [[alcohol]], [[diuretics]] in the evening and night&lt;br /&gt;
**less [[salt]] intake&lt;br /&gt;
**take naps in the afternoon&lt;br /&gt;
**[[weight loss]] in obese and overweight individuals&lt;br /&gt;
**[[urination]] before going to bed&lt;br /&gt;
**using compression stocks or elevating legs to reduce edema&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677510</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677510"/>
		<updated>2020-12-09T10:26:22Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Other Diagnostic Studies */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
&lt;br /&gt;
*Laboratory tests that should be helpful for the diagnosis of [[nocturia]] include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urine analysis]] with [[urine culture]] to rule out [[urinary tract infection]]&lt;br /&gt;
**serum [[electrolytes]]&lt;br /&gt;
**[[renal]] function tests such as [[BUN]], [[creatinine]], [[GFR]]&lt;br /&gt;
**serum glucose level and HbA1c to rule out [[diabetes mellitus]]&lt;br /&gt;
**[[lipid]] profile&lt;br /&gt;
**PSA level to rule out [[prostate cancer]] and [[BPH]]&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
&lt;br /&gt;
*[[Cystoscopy]] may be helpful in the diagnosis of [[bladder]] abnormalities that cause [[nocturia]]. &amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
=== Treatment===&lt;br /&gt;
* Treatment options for [[nocturia]] depend on the underlying causes.&lt;br /&gt;
*Behavioral modification includes &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** limiting fluid intake in the evening&lt;br /&gt;
**avoiding alcohol, coffee and tea &lt;br /&gt;
**treating underlying conditions such as chronic [[constipation]], [[diabetes mellitus]], [[diabetes insipidus]]&lt;br /&gt;
**elevation of the lower limbs in the evening &lt;br /&gt;
**avoiding [[diuretics]] intake in the evening and night&lt;br /&gt;
**[[physical exercise]]&lt;br /&gt;
* Pharmacologic medical therapies for [[nocturia]] include &lt;br /&gt;
**[[desmopressin]] ([[arginine]] [[vasopressin]]) &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
***It decreases urine volume through [[vasopressin]] V2 receptors, which leads to increase water reabsorption in [[renal tubules]].&lt;br /&gt;
*** It is the preferred drug for the treatment of [[nocturia]] due to nocturnal polyuria according to the European Association of Urology (EAU) recommendation. &amp;lt;ref name=&amp;quot;pmid23541338&amp;quot;&amp;gt;{{cite journal| author=Oelke M, Bachmann A, Descazeaud A, Emberton M, Gravas S, Michel MC | display-authors=etal| title=EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. | journal=Eur Urol | year= 2013 | volume= 64 | issue= 1 | pages= 118-40 | pmid=23541338 | doi=10.1016/j.eururo.2013.03.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23541338  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** α-blockers&lt;br /&gt;
** antimuscarinics&lt;br /&gt;
**phosphodiesterase type 5 inhibitors&lt;br /&gt;
**Botulinum toxin&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
&lt;br /&gt;
*Effective measures for the primary prevention of [[nocturia]] include [[lifestyle]] modifications such as &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**reducing intake of [[fluid]], [[caffeine]], [[alcohol]], [[diuretics]] in the evening and night&lt;br /&gt;
**less [[salt]] intake&lt;br /&gt;
**take naps in the afternoon&lt;br /&gt;
**[[weight loss]] in obese and overweight individuals&lt;br /&gt;
**[[urination]] before going to bed&lt;br /&gt;
**using compression stocks or elevating legs to reduce edema&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677509</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677509"/>
		<updated>2020-12-09T10:18:41Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Secondary Prevention */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
&lt;br /&gt;
*Laboratory tests that should be helpful for the diagnosis of [[nocturia]] include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urine analysis]] with [[urine culture]] to rule out [[urinary tract infection]]&lt;br /&gt;
**serum [[electrolytes]]&lt;br /&gt;
**[[renal]] function tests such as [[BUN]], [[creatinine]], [[GFR]]&lt;br /&gt;
**serum glucose level and HbA1c to rule out [[diabetes mellitus]]&lt;br /&gt;
**[[lipid]] profile&lt;br /&gt;
**PSA level to rule out [[prostate cancer]] and [[BPH]]&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
=== Treatment===&lt;br /&gt;
* Treatment options for [[nocturia]] depend on the underlying causes.&lt;br /&gt;
*Behavioral modification includes &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** limiting fluid intake in the evening&lt;br /&gt;
**avoiding alcohol, coffee and tea &lt;br /&gt;
**treating underlying conditions such as chronic [[constipation]], [[diabetes mellitus]], [[diabetes insipidus]]&lt;br /&gt;
**elevation of the lower limbs in the evening &lt;br /&gt;
**avoiding [[diuretics]] intake in the evening and night&lt;br /&gt;
**[[physical exercise]]&lt;br /&gt;
* Pharmacologic medical therapies for [[nocturia]] include &lt;br /&gt;
**[[desmopressin]] ([[arginine]] [[vasopressin]]) &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
***It decreases urine volume through [[vasopressin]] V2 receptors, which leads to increase water reabsorption in [[renal tubules]].&lt;br /&gt;
*** It is the preferred drug for the treatment of [[nocturia]] due to nocturnal polyuria according to the European Association of Urology (EAU) recommendation. &amp;lt;ref name=&amp;quot;pmid23541338&amp;quot;&amp;gt;{{cite journal| author=Oelke M, Bachmann A, Descazeaud A, Emberton M, Gravas S, Michel MC | display-authors=etal| title=EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. | journal=Eur Urol | year= 2013 | volume= 64 | issue= 1 | pages= 118-40 | pmid=23541338 | doi=10.1016/j.eururo.2013.03.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23541338  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** α-blockers&lt;br /&gt;
** antimuscarinics&lt;br /&gt;
**phosphodiesterase type 5 inhibitors&lt;br /&gt;
**Botulinum toxin&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
&lt;br /&gt;
*Effective measures for the primary prevention of [[nocturia]] include [[lifestyle]] modifications such as &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**reducing intake of [[fluid]], [[caffeine]], [[alcohol]], [[diuretics]] in the evening and night&lt;br /&gt;
**less [[salt]] intake&lt;br /&gt;
**take naps in the afternoon&lt;br /&gt;
**[[weight loss]] in obese and overweight individuals&lt;br /&gt;
**[[urination]] before going to bed&lt;br /&gt;
**using compression stocks or elevating legs to reduce edema&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677505</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677505"/>
		<updated>2020-12-09T09:34:58Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Primary Prevention */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
&lt;br /&gt;
*Laboratory tests that should be helpful for the diagnosis of [[nocturia]] include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urine analysis]] with [[urine culture]] to rule out [[urinary tract infection]]&lt;br /&gt;
**serum [[electrolytes]]&lt;br /&gt;
**[[renal]] function tests such as [[BUN]], [[creatinine]], [[GFR]]&lt;br /&gt;
**serum glucose level and HbA1c to rule out [[diabetes mellitus]]&lt;br /&gt;
**[[lipid]] profile&lt;br /&gt;
**PSA level to rule out [[prostate cancer]] and [[BPH]]&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
=== Treatment===&lt;br /&gt;
* Treatment options for [[nocturia]] depend on the underlying causes.&lt;br /&gt;
*Behavioral modification includes &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** limiting fluid intake in the evening&lt;br /&gt;
**avoiding alcohol, coffee and tea &lt;br /&gt;
**treating underlying conditions such as chronic [[constipation]], [[diabetes mellitus]], [[diabetes insipidus]]&lt;br /&gt;
**elevation of the lower limbs in the evening &lt;br /&gt;
**avoiding [[diuretics]] intake in the evening and night&lt;br /&gt;
**[[physical exercise]]&lt;br /&gt;
* Pharmacologic medical therapies for [[nocturia]] include &lt;br /&gt;
**[[desmopressin]] ([[arginine]] [[vasopressin]]) &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
***It decreases urine volume through [[vasopressin]] V2 receptors, which leads to increase water reabsorption in [[renal tubules]].&lt;br /&gt;
*** It is the preferred drug for the treatment of [[nocturia]] due to nocturnal polyuria according to the European Association of Urology (EAU) recommendation. &amp;lt;ref name=&amp;quot;pmid23541338&amp;quot;&amp;gt;{{cite journal| author=Oelke M, Bachmann A, Descazeaud A, Emberton M, Gravas S, Michel MC | display-authors=etal| title=EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. | journal=Eur Urol | year= 2013 | volume= 64 | issue= 1 | pages= 118-40 | pmid=23541338 | doi=10.1016/j.eururo.2013.03.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23541338  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** α-blockers&lt;br /&gt;
** antimuscarinics&lt;br /&gt;
**phosphodiesterase type 5 inhibitors&lt;br /&gt;
**Botulinum toxin&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
&lt;br /&gt;
*Effective measures for the primary prevention of [[nocturia]] include [[lifestyle]] modifications such as &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;urlNocturia: Causes, Treatments, and Prevention&amp;quot;&amp;gt;{{cite web |url=https://www.healthline.com/health/urination-excessive-at-night#prevention |title=Nocturia: Causes, Treatments, and Prevention |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**reducing intake of [[fluid]], [[caffeine]], [[alcohol]], [[diuretics]] in the evening and night&lt;br /&gt;
**less [[salt]] intake&lt;br /&gt;
**take naps in the afternoon&lt;br /&gt;
**[[weight loss]] in obese and overweight individuals&lt;br /&gt;
**[[urination]] before going to bed&lt;br /&gt;
**using compression stocks or elevating legs to reduce edema&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677503</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677503"/>
		<updated>2020-12-09T09:28:02Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Primary Prevention */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
&lt;br /&gt;
*Laboratory tests that should be helpful for the diagnosis of [[nocturia]] include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urine analysis]] with [[urine culture]] to rule out [[urinary tract infection]]&lt;br /&gt;
**serum [[electrolytes]]&lt;br /&gt;
**[[renal]] function tests such as [[BUN]], [[creatinine]], [[GFR]]&lt;br /&gt;
**serum glucose level and HbA1c to rule out [[diabetes mellitus]]&lt;br /&gt;
**[[lipid]] profile&lt;br /&gt;
**PSA level to rule out [[prostate cancer]] and [[BPH]]&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
=== Treatment===&lt;br /&gt;
* Treatment options for [[nocturia]] depend on the underlying causes.&lt;br /&gt;
*Behavioral modification includes &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** limiting fluid intake in the evening&lt;br /&gt;
**avoiding alcohol, coffee and tea &lt;br /&gt;
**treating underlying conditions such as chronic [[constipation]], [[diabetes mellitus]], [[diabetes insipidus]]&lt;br /&gt;
**elevation of the lower limbs in the evening &lt;br /&gt;
**avoiding [[diuretics]] intake in the evening and night&lt;br /&gt;
**[[physical exercise]]&lt;br /&gt;
* Pharmacologic medical therapies for [[nocturia]] include &lt;br /&gt;
**[[desmopressin]] ([[arginine]] [[vasopressin]]) &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
***It decreases urine volume through [[vasopressin]] V2 receptors, which leads to increase water reabsorption in [[renal tubules]].&lt;br /&gt;
*** It is the preferred drug for the treatment of [[nocturia]] due to nocturnal polyuria according to the European Association of Urology (EAU) recommendation. &amp;lt;ref name=&amp;quot;pmid23541338&amp;quot;&amp;gt;{{cite journal| author=Oelke M, Bachmann A, Descazeaud A, Emberton M, Gravas S, Michel MC | display-authors=etal| title=EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. | journal=Eur Urol | year= 2013 | volume= 64 | issue= 1 | pages= 118-40 | pmid=23541338 | doi=10.1016/j.eururo.2013.03.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23541338  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** α-blockers&lt;br /&gt;
** antimuscarinics&lt;br /&gt;
**phosphodiesterase type 5 inhibitors&lt;br /&gt;
**Botulinum toxin&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*Effective measures for the primary prevention of [[nocturia]] include [[lifestyle]] modifications such as &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**reducing intake of [[fluid]], [[caffeine]], [[alcohol]], [[diuretics]] in the evening and night&lt;br /&gt;
**less [[salt]] intake&lt;br /&gt;
**take naps in the afternoon&lt;br /&gt;
**[[weight loss]] in obese and overweight individuals&lt;br /&gt;
**urination before going to bed&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677375</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677375"/>
		<updated>2020-12-08T21:22:11Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
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&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
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&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
&lt;br /&gt;
*Laboratory tests that should be helpful for the diagnosis of [[nocturia]] include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urine analysis]] with [[urine culture]] to rule out [[urinary tract infection]]&lt;br /&gt;
**serum [[electrolytes]]&lt;br /&gt;
**[[renal]] function tests such as [[BUN]], [[creatinine]], [[GFR]]&lt;br /&gt;
**serum glucose level and HbA1c to rule out [[diabetes mellitus]]&lt;br /&gt;
**[[lipid]] profile&lt;br /&gt;
**PSA level to rule out [[prostate cancer]] and [[BPH]]&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
=== Treatment===&lt;br /&gt;
* Treatment options for [[nocturia]] depend on the underlying causes.&lt;br /&gt;
*Behavioral modification includes &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** limiting fluid intake in the evening&lt;br /&gt;
**avoiding alcohol, coffee and tea &lt;br /&gt;
**treating underlying conditions such as chronic [[constipation]], [[diabetes mellitus]], [[diabetes insipidus]]&lt;br /&gt;
**elevation of the lower limbs in the evening &lt;br /&gt;
**avoiding [[diuretics]] intake in the evening and night&lt;br /&gt;
**[[physical exercise]]&lt;br /&gt;
* Pharmacologic medical therapies for [[nocturia]] include &lt;br /&gt;
**[[desmopressin]] ([[arginine]] [[vasopressin]]) &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
***It decreases urine volume through [[vasopressin]] V2 receptors, which leads to increase water reabsorption in [[renal tubules]].&lt;br /&gt;
*** It is the preferred drug for the treatment of [[nocturia]] due to nocturnal polyuria according to the European Association of Urology (EAU) recommendation. &amp;lt;ref name=&amp;quot;pmid23541338&amp;quot;&amp;gt;{{cite journal| author=Oelke M, Bachmann A, Descazeaud A, Emberton M, Gravas S, Michel MC | display-authors=etal| title=EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction. | journal=Eur Urol | year= 2013 | volume= 64 | issue= 1 | pages= 118-40 | pmid=23541338 | doi=10.1016/j.eururo.2013.03.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23541338  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** α-blockers&lt;br /&gt;
** antimuscarinics&lt;br /&gt;
**phosphodiesterase type 5 inhibitors&lt;br /&gt;
**Botulinum toxin&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677374</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677374"/>
		<updated>2020-12-08T21:15:12Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Electrocardiogram */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
&lt;br /&gt;
*Laboratory tests that should be helpful for the diagnosis of [[nocturia]] include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urine analysis]] with [[urine culture]] to rule out [[urinary tract infection]]&lt;br /&gt;
**serum [[electrolytes]]&lt;br /&gt;
**[[renal]] function tests such as [[BUN]], [[creatinine]], [[GFR]]&lt;br /&gt;
**serum glucose level and HbA1c to rule out [[diabetes mellitus]]&lt;br /&gt;
**[[lipid]] profile&lt;br /&gt;
**PSA level to rule out [[prostate cancer]] and [[BPH]]&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677373</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677373"/>
		<updated>2020-12-08T21:14:31Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Laboratory Findings */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
&lt;br /&gt;
*Laboratory tests that should be helpful for the diagnosis of [[nocturia]] include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urine analysis]] with [[urine culture]] to rule out [[urinary tract infection]]&lt;br /&gt;
**serum [[electrolytes]]&lt;br /&gt;
**[[renal]] function tests such as [[BUN]], [[creatinine]], [[GFR]]&lt;br /&gt;
**serum glucose level and HbA1c to rule out [[diabetes mellitus]]&lt;br /&gt;
**[[lipid]] profile&lt;br /&gt;
**PSA level to rule out [[prostate cancer]] and [[BPH]]&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677372</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677372"/>
		<updated>2020-12-08T21:12:01Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Physical Examination */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
&lt;br /&gt;
*physical examination should include &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Checking [[Blood pressure]]&lt;br /&gt;
**[[digital rectal examination]] of the [[prostate]] in men and pelvic examination in women&lt;br /&gt;
**checking [[edema]] of the lower limbs&lt;br /&gt;
**checking [[genitalia]] diseases (phimosis, meatal stenosis or cancer)&lt;br /&gt;
**abdominal examination especially [[bladder]] to assess [[urinary retention]]&lt;br /&gt;
**calculating BMI and/or waist circumference&lt;br /&gt;
**filling the chart of Frequency-volume for at least 3 days&lt;br /&gt;
&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Test] is usually normal among patients with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no diagnostic laboratory findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677371</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677371"/>
		<updated>2020-12-08T21:10:53Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* History and Symptoms */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
&lt;br /&gt;
*The most common symptoms of [[nocturia]] include passing urine, [[urgency]] and [[frequency]] at nights. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*History of fluid, [[alcohol]] and [[caffeine]] intake, [[urinary]] symptoms, [[medications]] , sleep disorders should be asked from the patients. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** Some [[medications]] that cause [[nocturia]] include [[diuretics]], [[amlodipine]] and [[nifedipine]] should be discontinued.&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Test] is usually normal among patients with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no diagnostic laboratory findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677370</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1677370"/>
		<updated>2020-12-08T21:05:37Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Diagnostic Study of Choice */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep),&lt;br /&gt;
***the number of urinations and the amount of urine production during the day&lt;br /&gt;
* Frequency- volume charts can be diagnostic for [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
The majority of patients with [disease name] are asymptomatic.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Test] is usually normal among patients with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no diagnostic laboratory findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1676990</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1676990"/>
		<updated>2020-12-07T14:22:54Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Diagnostic Study of Choice */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
*The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 times to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
*According to new revised definition in 2017 , nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Bladder diary should be asked from the patients, including &amp;lt;ref name=&amp;quot;pmid29410891&amp;quot;&amp;gt;{{cite journal| author=Miotła P, Dobruch J, Lipiński M, Drewa T, Kołodziej A, Barcz E | display-authors=etal| title=Diagnostic and therapeutic recommendations for patients with nocturia. | journal=Cent European J Urol | year= 2017 | volume= 70 | issue= 4 | pages= 388-393 | pmid=29410891 | doi=10.5173/ceju.2017.1563 | pmc=5791408 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29410891  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**the amount of water intake&lt;br /&gt;
**the time of water intake&lt;br /&gt;
**time and volume of urination&lt;br /&gt;
***the number of urinations during the day&lt;br /&gt;
***the number of nocturia (urination during the sleep)&lt;br /&gt;
***the number of urination and the amount of urine production during the day&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
The majority of patients with [disease name] are asymptomatic.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Test] is usually normal among patients with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no diagnostic laboratory findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1676974</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1676974"/>
		<updated>2020-12-07T13:25:26Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Diagnostic Study of Choice */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [[nocturia]] is based on the clinical history defined by International Continence Society (ICS) in 2002, which includes wake up at night ≥1 time to void. &amp;lt;ref name=&amp;quot;pmid11857672&amp;quot;&amp;gt;{{cite journal| author=van Kerrebroeck P, Abrams P, Chaikin D, Donovan J, Fonda D, Jackson S | display-authors=etal| title=The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 179-83 | pmid=11857672 | doi=10.1002/nau.10053 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857672  }} &amp;lt;/ref&amp;gt; &lt;br /&gt;
&lt;br /&gt;
According to new revised definition in 2017, nocturia is to wake up to void during the sleep period. &amp;lt;ref name=&amp;quot;pmid30644584&amp;quot;&amp;gt;{{cite journal| author=Hashim H, Blanker MH, Drake MJ, Djurhuus JC, Meijlink J, Morris V | display-authors=etal| title=International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. | journal=Neurourol Urodyn | year= 2019 | volume= 38 | issue= 2 | pages= 499-508 | pmid=30644584 | doi=10.1002/nau.23917 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=30644584  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
The majority of patients with [disease name] are asymptomatic.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Test] is usually normal among patients with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no diagnostic laboratory findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1676176</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1676176"/>
		<updated>2020-12-01T21:37:32Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Historical Perspective */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
*[[Nocturia]] was defined by International Continence Society (ICS) in 2002, as the need to wake up one or more times at nights to [[void]]. &amp;lt;ref name=&amp;quot;pmid11857671&amp;quot;&amp;gt;{{cite journal| author=Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U | display-authors=etal| title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. | journal=Neurourol Urodyn | year= 2002 | volume= 21 | issue= 2 | pages= 167-78 | pmid=11857671 | doi=10.1002/nau.10052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11857671  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Clinical definition of [[nocturia]] is awaking from sleep to urinate two or more that two times per night. &amp;lt;ref name=&amp;quot;pmid24729150&amp;quot;&amp;gt;{{cite journal| author=Van Kerrebroeck P, Andersson KE| title=Terminology, epidemiology, etiology, and pathophysiology of nocturia. | journal=Neurourol Urodyn | year= 2014 | volume= 33 Suppl 1 | issue=  | pages= S2-5 | pmid=24729150 | doi=10.1002/nau.22595 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=24729150  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid28984060&amp;quot;&amp;gt;{{cite journal| author=Oelke M, De Wachter S, Drake MJ, Giannantoni A, Kirby M, Orme S | display-authors=etal| title=A practical approach to the management of nocturia. | journal=Int J Clin Pract | year= 2017 | volume= 71 | issue= 11 | pages=  | pmid=28984060 | doi=10.1111/ijcp.13027 | pmc=5698733 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28984060  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no established criteria for the diagnosis of [disease name].&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
The majority of patients with [disease name] are asymptomatic.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Test] is usually normal among patients with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no diagnostic laboratory findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1675663</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1675663"/>
		<updated>2020-11-23T14:19:52Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Natural History, Complications, and Prognosis */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
*Common complications of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10869627&amp;quot;&amp;gt;{{cite journal| author=Schatzl G, Temml C, Schmidbauer J, Dolezal B, Haidinger G, Madersbacher S| title=Cross-sectional study of nocturia in both sexes: analysis of a voluntary health screening project. | journal=Urology | year= 2000 | volume= 56 | issue= 1 | pages= 71-5 | pmid=10869627 | doi=10.1016/s0090-4295(00)00603-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10869627  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18703381&amp;quot;&amp;gt;{{cite journal| author=Bliwise DL, Foley DJ, Vitiello MV, Ansari FP, Ancoli-Israel S, Walsh JK| title=Nocturia and disturbed sleep in the elderly. | journal=Sleep Med | year= 2009 | volume= 10 | issue= 5 | pages= 540-8 | pmid=18703381 | doi=10.1016/j.sleep.2008.04.002 | pmc=2735085 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18703381  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid20727545&amp;quot;&amp;gt;{{cite journal| author=Nakagawa H, Niu K, Hozawa A, Ikeda Y, Kaiho Y, Ohmori-Matsuda K | display-authors=etal| title=Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. | journal=J Urol | year= 2010 | volume= 184 | issue= 4 | pages= 1413-8 | pmid=20727545 | doi=10.1016/j.juro.2010.05.093 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20727545  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid22425119&amp;quot;&amp;gt;{{cite journal| author=van Doorn B, Kok ET, Blanker MH, Westers P, Bosch JL| title=Mortality in older men with nocturia. A 15-year followup of the Krimpen study. | journal=J Urol | year= 2012 | volume= 187 | issue= 5 | pages= 1727-31 | pmid=22425119 | doi=10.1016/j.juro.2011.12.078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22425119  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Sleep disorders]]&lt;br /&gt;
** [[Depression]]&lt;br /&gt;
** [[anxiety disorders]]&lt;br /&gt;
**lower [[quality of life]] &lt;br /&gt;
** increased risk of falling and [[bone]] [[fracture]]&lt;br /&gt;
**increased [[mortality]]&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no established criteria for the diagnosis of [disease name].&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
The majority of patients with [disease name] are asymptomatic.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Test] is usually normal among patients with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no diagnostic laboratory findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1675657</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1675657"/>
		<updated>2020-11-23T13:28:59Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Screening */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [[nocturia]].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no established criteria for the diagnosis of [disease name].&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
The majority of patients with [disease name] are asymptomatic.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Test] is usually normal among patients with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no diagnostic laboratory findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1675646</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1675646"/>
		<updated>2020-11-23T12:33:59Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Risk Factors */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
*Common risk factors in the development of [[nocturia]] include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15147543&amp;quot;&amp;gt;{{cite journal| author=Yoshimura K, Terada N, Matsui Y, Terai A, Kinukawa N, Arai Y| title=Prevalence of and risk factors for nocturia: Analysis of a health screening program. | journal=Int J Urol | year= 2004 | volume= 11 | issue= 5 | pages= 282-7 | pmid=15147543 | doi=10.1111/j.1442-2042.2004.00791.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15147543  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[aging]]&lt;br /&gt;
**Hispanic and Black race&lt;br /&gt;
**history of [[nocturia]] during childhood&lt;br /&gt;
**history of pre-existing conditions&lt;br /&gt;
***[[Diabetes mellitus]]&lt;br /&gt;
***[[Diabetes insipidus]]&lt;br /&gt;
***[[Hypertension]]&lt;br /&gt;
***[[Arthritis]]&lt;br /&gt;
*** [[Airway disease]] such as [[Asthma]]&lt;br /&gt;
**history of psychological disease&lt;br /&gt;
***[[Depression]]&lt;br /&gt;
***[[Anxiety disorders]]&lt;br /&gt;
**history of [[diuretic]] intake&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in men include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid15935026&amp;quot;&amp;gt;{{cite journal| author=Johnson TM, Sattin RW, Parmelee P, Fultz NH, Ouslander JG| title=Evaluating potentially modifiable risk factors for prevalent and incident nocturia in older adults. | journal=J Am Geriatr Soc | year= 2005 | volume= 53 | issue= 6 | pages= 1011-6 | pmid=15935026 | doi=10.1111/j.1532-5415.2005.53321.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15935026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
** [[prostatitis]]&lt;br /&gt;
** [[benign prostatic hyperplasia]]&lt;br /&gt;
** [[prostate cancer]]&lt;br /&gt;
* Potent risk factors in the development of [[nocturia]] in women include&amp;lt;ref name=&amp;quot;pmid26351086&amp;quot;&amp;gt;{{cite journal| author=Madhu C, Coyne K, Hashim H, Chapple C, Milsom I, Kopp Z| title=Nocturia: risk factors and associated comorbidities; findings from the EpiLUTS study. | journal=Int J Clin Pract | year= 2015 | volume= 69 | issue= 12 | pages= 1508-16 | pmid=26351086 | doi=10.1111/ijcp.12727 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=26351086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**high [[BMI]]&lt;br /&gt;
** [[Heart disease]]&lt;br /&gt;
**[[Inflammatory bowel disease]]&lt;br /&gt;
**[[Uterine prolapse]]&lt;br /&gt;
**[[Hysterectomy]]&lt;br /&gt;
**[[Menopause]]&lt;br /&gt;
**recurrent [[UTI]]&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [disease/malignancy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
According to the [guideline name], screening for [disease name] is not recommended.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
According to the [guideline name], screening for [disease name] by [test 1] is recommended every [duration] among patients with [condition 1], [condition 2], and [condition 3].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no established criteria for the diagnosis of [disease name].&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
The majority of patients with [disease name] are asymptomatic.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Test] is usually normal among patients with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no diagnostic laboratory findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1675330</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1675330"/>
		<updated>2020-11-16T04:30:49Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Epidemiology and Demographics */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 1 voids is approximately 69000 per 100,000 [[men]] aged ≥ 40 years and 76000 per 100,000 [[women]] aged ≥ 40 years in the United States, United Kingdom, and Sweden. &amp;lt;ref name=&amp;quot;pmid19302497&amp;quot;&amp;gt;{{cite journal| author=Coyne KS, Wein AJ, Tubaro A, Sexton CC, Thompson CL, Kopp ZS | display-authors=etal| title=The burden of lower urinary tract symptoms: evaluating the effect of LUTS on health-related quality of life, anxiety and depression: EpiLUTS. | journal=BJU Int | year= 2009 | volume= 103 Suppl 3 | issue=  | pages= 4-11 | pmid=19302497 | doi=10.1111/j.1464-410X.2009.08371.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19302497  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 20-30 years is approximately 4000 to 18000 per 100,000 women and 2000 to 17000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*The prevalence of [[nocturia]] ≥ 2 voids in population aged 70-80 years is 28000 to 62000 per 100,000 women and 29000 to 59000 per 100,000 men. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* The prevalence of [[nocturia]] ≥ 2 voids in in Canada, Germany, Italy, Sweden, and the United Kingdom is 13000 to 17000 per 100,000 individuals aged &amp;lt; 40 years and 20000 to 21000 per 100,000 middle-aged populations and 35000 to 36000 per 100,000 individuals aged ≥ 60 years. &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
*The incidence of [[nocturia]] increases with age. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[Nocturia]] can affect younger people as 1 from 5 or 6 younger population wake up at least two times per night to void. &amp;lt;ref name=&amp;quot;pmid20620395&amp;quot;&amp;gt;{{cite journal| author=Bosch JL, Weiss JP| title=The prevalence and causes of nocturia. | journal=J Urol | year= 2010 | volume= 184 | issue= 2 | pages= 440-6 | pmid=20620395 | doi=10.1016/j.juro.2010.04.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=20620395  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid17049716&amp;quot;&amp;gt;{{cite journal| author=Irwin DE, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S | display-authors=etal| title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. | journal=Eur Urol | year= 2006 | volume= 50 | issue= 6 | pages= 1306-14; discussion 1314-5 | pmid=17049716 | doi=10.1016/j.eururo.2006.09.019 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=17049716  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
* [[non-Hispanic black]] men are more likely to develop [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid21251675&amp;quot;&amp;gt;{{cite journal| author=Markland AD, Vaughan CP, Johnson TM, Goode PS, Redden DT, Burgio KL| title=Prevalence of nocturia in United States men: results from the National Health and Nutrition Examination Survey. | journal=J Urol | year= 2011 | volume= 185 | issue= 3 | pages= 998-1002 | pmid=21251675 | doi=10.1016/j.juro.2010.10.083 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21251675  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*[[nocturia]] affects men and women equally. However, [[nocturia]] incidence are more in young women than young men, and also old men are more likely to develop [[nocturia]] than old women. &amp;lt;ref name=&amp;quot;pmid16086673&amp;quot;&amp;gt;{{cite journal| author=Hunskaar S| title=Epidemiology of nocturia. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 4-7 | pmid=16086673 | doi=10.1111/j.1464-410X.2005.05650.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086673  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
There are no established risk factors for [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [disease/malignancy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
According to the [guideline name], screening for [disease name] is not recommended.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
According to the [guideline name], screening for [disease name] by [test 1] is recommended every [duration] among patients with [condition 1], [condition 2], and [condition 3].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no established criteria for the diagnosis of [disease name].&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
The majority of patients with [disease name] are asymptomatic.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Test] is usually normal among patients with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no diagnostic laboratory findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1674549</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1674549"/>
		<updated>2020-11-08T02:05:42Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Pathophysiology */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate of [number range]%.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Patients of all age groups may develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] commonly affects individuals younger than/older than [number of years] years of age.&lt;br /&gt;
&lt;br /&gt;
OR &lt;br /&gt;
&lt;br /&gt;
[Chronic disease name] is usually first diagnosed among [age group].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Acute disease name] commonly affects [age group].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
There is no racial predilection to [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[Disease name] affects men and women equally.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number &amp;gt; 1] to 1.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The majority of [disease name] cases are reported in [geographical region].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
There are no established risk factors for [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [disease/malignancy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
According to the [guideline name], screening for [disease name] is not recommended.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
According to the [guideline name], screening for [disease name] by [test 1] is recommended every [duration] among patients with [condition 1], [condition 2], and [condition 3].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no established criteria for the diagnosis of [disease name].&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
The majority of patients with [disease name] are asymptomatic.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Test] is usually normal among patients with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no diagnostic laboratory findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1674548</id>
		<title>Nocturia</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Nocturia&amp;diff=1674548"/>
		<updated>2020-11-08T02:03:18Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: /* Pathophysiology */&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
&#039;&#039;&#039;For patient information click [[Nocturia (patient information)|here]]&#039;&#039;&#039;&lt;br /&gt;
&lt;br /&gt;
{{Infobox_Disease |&lt;br /&gt;
  Name        = Nocturia |&lt;br /&gt;
  ICD10       = {{ICD10|R|35||r|30}} |&lt;br /&gt;
  ICD9        = {{ICD9|788.43}} |&lt;br /&gt;
}} &lt;br /&gt;
{{Search infobox}}&lt;br /&gt;
{{SCC}}; {{AE}} {{VSKP}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&#039;&#039;&#039;Nocturia&#039;&#039;&#039; (derived from [[Latin language|Latin]] &#039;&#039;nox, night&#039;&#039;, and [[Greek language|Greek]] &#039;&#039;[τα] ούρα, urine&#039;&#039;), also called &#039;&#039;&#039;nycturia&#039;&#039;&#039; (Greek &#039;&#039;νυκτουρία&#039;&#039;), is the need to get up during the night in order to urinate, thus interrupting sleep.  Its occurrence is more frequent in the elderly.  Nocturia could result simply from too much liquid intake before going to bed, or it could be a symptom of a larger problem, such as [[chronic renal failure]], [[urinary incontinence]], [[Interstitial Cystitis]], [[diabetes]], [[benign prostatic hyperplasia]], [[Ureteropelvic junction obstruction]]&amp;lt;ref&amp;gt;[http://www.emoryhealthcare.org/departments/urology/sub_menu/upj.html Ureteral Pelvic Junction Obstruction desc.]&amp;lt;/ref&amp;gt; or [[prostate cancer]].&lt;br /&gt;
&lt;br /&gt;
==Historical Perspective==&lt;br /&gt;
[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].&lt;br /&gt;
&lt;br /&gt;
The association between [important risk factor/cause] and [disease name] was made in/during [year/event].&lt;br /&gt;
&lt;br /&gt;
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].&lt;br /&gt;
&lt;br /&gt;
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].&lt;br /&gt;
&lt;br /&gt;
There have been several outbreaks of [disease name], including -----.&lt;br /&gt;
&lt;br /&gt;
In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Pathophysiology==&lt;br /&gt;
*It is thought that [[nocturia]] is caused by a number of factors, including&amp;lt;ref name=&amp;quot;pmid21355977&amp;quot;&amp;gt;{{cite journal| author=Gulur DM, Mevcha AM, Drake MJ| title=Nocturia as a manifestation of systemic disease. | journal=BJU Int | year= 2011 | volume= 107 | issue= 5 | pages= 702-713 | pmid=21355977 | doi=10.1111/j.1464-410X.2010.09763.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=21355977  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[urological]] disorders&lt;br /&gt;
***abnormalities of [[bladder]] capacity&lt;br /&gt;
***[[prostate]] enlargement&lt;br /&gt;
**[[urine]] overproduction due to&lt;br /&gt;
*** depletion of [[third-space]] fluid in [[overload]] states following a recumbent position during sleep&lt;br /&gt;
***overproduction of [[atrial natriuretic peptide]] (ANP) caused by&lt;br /&gt;
****[[sleep apnea]]&lt;br /&gt;
****[[congestive heart failure]]&lt;br /&gt;
*** deficiency or dysfunction of [[antidiuretic hormone]] (ADH) or [[arginine vasopressin]] (AVP)&lt;br /&gt;
***[[medications]] such as [[diuretics]]&lt;br /&gt;
***[[behavioral]] factors such as high water intake at night&lt;br /&gt;
*AVP regulates [[urine]] production by [[antidiuretic]] effects in the collecting system in the [[kidneys]], resulted in&amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increasing water reabsorption&lt;br /&gt;
**decreasing [[urine volume]]&lt;br /&gt;
*AVP deficiency or AVP dysfunction leads to decreasing [[urine]] concentration, increasing [[urine volume]] and [[nocturia]]. &amp;lt;ref name=&amp;quot;pmid23526404&amp;quot;&amp;gt;{{cite journal| author=Weiss JP| title=Nocturia: focus on etiology and consequences. | journal=Rev Urol | year= 2012 | volume= 14 | issue= 3-4 | pages= 48-55 | pmid=23526404 | doi= | pmc=3602727 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23526404  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid19226359&amp;quot;&amp;gt;{{cite journal| author=Schneider T, de la Rosette JJ, Michel MC| title=Nocturia: a non-specific but important symptom of urological disease. | journal=Int J Urol | year= 2009 | volume= 16 | issue= 3 | pages= 249-56 | pmid=19226359 | doi=10.1111/j.1442-2042.2008.02246.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=19226359  }} &amp;lt;/ref&lt;br /&gt;
&lt;br /&gt;
==Causes==&lt;br /&gt;
&lt;br /&gt;
===Causes by Pathogenesis===&lt;br /&gt;
&lt;br /&gt;
{{familytree/start}}&lt;br /&gt;
{{familytree | | | | | | | | | | B01 | | | | | |B01=Causes of Nocturia}}&lt;br /&gt;
{{familytree | | | | | |,|-|-|-|-|^|-|-|-|-|-|.| }}&lt;br /&gt;
{{familytree | | | | | C01 | | | | | | | | | C03 |C01=Due to Hormonal imbalance|C03=Due to Vesical problems}}&lt;br /&gt;
{{familytree | | | | | |!| | | | | | | | | | |!| }}&lt;br /&gt;
{{familytree | |,|-|-|-|+|-|-|-|.| | | | | | |!| }}&lt;br /&gt;
{{familytree | |!| | | |!| | | |!| | | | | | |!| }}&lt;br /&gt;
{{familytree | D01 | | D02 | | D03 | | | | | D05 |D01=Global Polyuria|D02=Nocturanl Polyuria|D03=Sleep disorders|D05=Bladder storage disorders}}&lt;br /&gt;
{{familytree/end}}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Hormonal Imbalance====&lt;br /&gt;
&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 30%;&amp;quot; | Global Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Nocturnal Polyuria&lt;br /&gt;
! style=&amp;quot;width: 35%;&amp;quot; | Sleep disorders&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Defined as a 24-hour urine volume that exceeds 3 liters per day (or 40 mL per kg). The common causes of global polyuria are &lt;br /&gt;
*[[Diabetes mellitus]]- caused by low levels of [[Insulin]] &lt;br /&gt;
*[[Diabetes insipidus]]- caused by low levels of [[AVP]]&lt;br /&gt;
| valign = top |&lt;br /&gt;
Nocturnal polyuria is defined as an increase in urine production during the night but with a proportional decrease in daytime urine production that results in a normal 24-hour urine volume. Nocturnal polyuria may be due to age-related changes in the secretion and action of [[arginine vasopressin]] [[(AVP)]]. There is a diurnal periodicity in AVP release in young, healthy subjects, with higher [[AVP]] plasma levels in the evening contributing to decreased nighttime urine output. The diurnal variation in [[AVP]] release is absent in many older people. Compared with the normal patients, nocturia patients have a nocturnal decrease in [[AVP]] level. Other causes of nocturnal polyuria include diseases such as &lt;br /&gt;
*[[congestive heart failure]], &lt;br /&gt;
*[[nephrotic syndrome]] and &lt;br /&gt;
*[[Hepatic failure]] or &lt;br /&gt;
*lifestyle patterns such as excessive nighttime drinking.&lt;br /&gt;
| valign = top |&lt;br /&gt;
Sleep disorders have been demonstrated to be a frequent cause of nocturia in men younger than 50 years and in women with symptoms of daytime overactive bladder syndrome. Primary sleep disorders may result in nocturia either because of hormonal changes related to sleep-disordered breathing or due to patient misperception of the reason for awakening due to the sleep disturbance but recall this as an awakening to void.&lt;br /&gt;
e.g.&lt;br /&gt;
*[[Sleep apnea|Obstructive sleep apnea]]([[OSA]])&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
[[OSA]] may also cause nocturnal polyuria by release of [[atrial natriuretic peptide]] ([[ANP]]).&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
====Causes Due to Vesical Problems====&lt;br /&gt;
{| class=&amp;quot;wikitable&amp;quot;&lt;br /&gt;
|-&lt;br /&gt;
! style=&amp;quot;width: 20%;&amp;quot; | Bladder storage disorder&lt;br /&gt;
|-&lt;br /&gt;
| valign = top |&lt;br /&gt;
Reduced bladder capacity or impaired bladder function results in low-volume voids. Most common causes of low-volume bladder voids are&lt;br /&gt;
*[[Overactive bladder]] (e.g. [[Urge incontinence]])&lt;br /&gt;
*[[Bladder outlet obstruction]] (e.g. [[BPH]])&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes by Organ System===&lt;br /&gt;
&lt;br /&gt;
{|style=&amp;quot;width:80%; height:100px&amp;quot; border=&amp;quot;1&amp;quot;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:25%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;LightSteelBlue&amp;quot; |&#039;&#039;&#039;Cardiovascular&#039;&#039;&#039;&lt;br /&gt;
|style=&amp;quot;height:100px&amp;quot;; style=&amp;quot;width:75%&amp;quot; border=&amp;quot;1&amp;quot; bgcolor=&amp;quot;Beige&amp;quot; | [[Heart failure]] &lt;br /&gt;
|-&lt;br /&gt;
|bgcolor=&amp;quot;LightSteelBlue&amp;quot;| &#039;&#039;&#039;Chemical/Poisoning&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Dermatologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Drug Side Effect&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Bicalutamide]], [[Cardiac glycosides]], [[Demeclocycline]], [[Diuretics]], [[Vitamin D|Excessive vitamin D intake]], [[Lithium]], [[Methoxyflurane]], [[Phenytoin]], [[Propoxyphene]], [[Tiagabine]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ear Nose Throat&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Endocrine&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Liver failure]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Environmental&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Gastroenterologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Genetic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Hematologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Iatrogenic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Infectious Disease&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Interstitial cystitis]], [[UTI|Recurrent UTI]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Musculoskeletal/Orthopedic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Neurologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;|  [[Detrusor hyperactivity]], [[Diabetes insipidus]], [[Neurogenic bladder ]], [[Parkinson disease]], [[Restless leg syndrome]], [[Urge incontinence]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Nutritional/Metabolic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Diabetes]], [[Obesity]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Obstetric/Gynecologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Oncologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Prostate cancer]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Ophthalmologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Overdose/Toxicity&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Psychiatric&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Anxiety disorders]], [[Depression]], [[Obstructive sleep apnea]], [[Polydipsia|Primary polydipsia]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Pulmonary&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Renal/Electrolyte&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Chronic renal failure]], [[Diabetes insipidus]], [[Nephrotic syndrome]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Rheumatology/Immunology/Allergy&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Sexual&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Trauma&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| No underlying causes&lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Urologic&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Benign prostatic hyperplasia]], [[Bladder outlet obstruction]], [[Detrusor hyperactivity]], [[Prostatitis|Granulomatous prostatitis]], [[Interstitial cystitis]], [[Neurogenic bladder]], [[Prostate cancer]], [[Ureteropelvic junction obstruction]] &lt;br /&gt;
|-&lt;br /&gt;
|-bgcolor=&amp;quot;LightSteelBlue&amp;quot;&lt;br /&gt;
| &#039;&#039;&#039;Miscellaneous&#039;&#039;&#039;&lt;br /&gt;
|bgcolor=&amp;quot;Beige&amp;quot;| [[Paruresis|Learned voiding dysfunction]], [[Venous insufficiency]] &lt;br /&gt;
|-&lt;br /&gt;
|}&lt;br /&gt;
&lt;br /&gt;
===Causes in Alphabetical Order===&lt;br /&gt;
{{columns-list|&lt;br /&gt;
 &lt;br /&gt;
*[[Anxiety disorders]]&lt;br /&gt;
*[[Benign prostatic hyperplasia]]&lt;br /&gt;
*[[Bicalutamide]]&lt;br /&gt;
*[[Bladder outlet obstruction]]&lt;br /&gt;
*[[Cardiac glycosides]]&lt;br /&gt;
*[[Chronic renal failure]]&lt;br /&gt;
*[[Demeclocycline]]&lt;br /&gt;
*[[Depression]]&lt;br /&gt;
*[[Detrusor hyperactivity]]&lt;br /&gt;
*[[Diabetes]]&lt;br /&gt;
*[[Diabetes insipidus]]&lt;br /&gt;
*[[Diuretics]]&lt;br /&gt;
*[[Vitamin D|Excessive vitamin D intake]]&lt;br /&gt;
*[[Prostatitis|Granulomatous prostatitis]]&lt;br /&gt;
*[[Heart failure]]&lt;br /&gt;
*[[Interstitial cystitis]]&lt;br /&gt;
*[[Learned voiding dysfunction]]&lt;br /&gt;
*[[Lithium]]&lt;br /&gt;
*[[Liver failure]]&lt;br /&gt;
*[[Methoxyflurane]]&lt;br /&gt;
*[[Nephrotic syndrome]]&lt;br /&gt;
*[[Neurogenic bladder ]]&lt;br /&gt;
*[[Obesity]]&lt;br /&gt;
*[[Obstructive sleep apnea ]]&lt;br /&gt;
*[[Parkinson disease]]&lt;br /&gt;
*[[Phenytoin]]&lt;br /&gt;
*[[Primary hyperaldosteronism]]&lt;br /&gt;
*[[Propoxyphene]]&lt;br /&gt;
*[[Polydipsia|Primary polydipsia]]&lt;br /&gt;
*[[Prostate cancer]]&lt;br /&gt;
*[[UTI|Recurrent UTI]]&lt;br /&gt;
*[[Restless leg syndrome]]&lt;br /&gt;
*[[Tiagabine]]&lt;br /&gt;
*[[Ureteropelvic junction obstruction]]&lt;br /&gt;
*[[Urge incontinence]]&lt;br /&gt;
*[[Venous insufficiency]]&lt;br /&gt;
}}&lt;br /&gt;
==Differentiating ((Page name)) from other Diseases==&lt;br /&gt;
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].&lt;br /&gt;
&lt;br /&gt;
==Epidemiology and Demographics==&lt;br /&gt;
The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate of [number range]%.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
Patients of all age groups may develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] commonly affects individuals younger than/older than [number of years] years of age.&lt;br /&gt;
&lt;br /&gt;
OR &lt;br /&gt;
&lt;br /&gt;
[Chronic disease name] is usually first diagnosed among [age group].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Acute disease name] commonly affects [age group].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
There is no racial predilection to [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
[Disease name] affects men and women equally.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number &amp;gt; 1] to 1.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
The majority of [disease name] cases are reported in [geographical region].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].&lt;br /&gt;
&lt;br /&gt;
==Risk Factors==&lt;br /&gt;
There are no established risk factors for [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.&lt;br /&gt;
&lt;br /&gt;
==Screening==&lt;br /&gt;
There is insufficient evidence to recommend routine screening for [disease/malignancy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
According to the [guideline name], screening for [disease name] is not recommended.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
According to the [guideline name], screening for [disease name] by [test 1] is recommended every [duration] among patients with [condition 1], [condition 2], and [condition 3].&lt;br /&gt;
&lt;br /&gt;
==Natural History, Complications, and Prognosis==&lt;br /&gt;
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.&lt;br /&gt;
&lt;br /&gt;
==Diagnosis==&lt;br /&gt;
===Diagnostic Study of Choice===&lt;br /&gt;
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no established criteria for the diagnosis of [disease name].&lt;br /&gt;
&lt;br /&gt;
===History and Symptoms===&lt;br /&gt;
The majority of patients with [disease name] are asymptomatic.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].&lt;br /&gt;
&lt;br /&gt;
===Physical Examination===&lt;br /&gt;
Patients with [disease name] usually appear [general appearance]. Physical examination of patients with [disease name] is usually remarkable for [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Common physical examination findings of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The presence of [finding(s)] on physical examination is highly suggestive of [disease name].&lt;br /&gt;
===Laboratory Findings===&lt;br /&gt;
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Test] is usually normal among patients with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no diagnostic laboratory findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
===Electrocardiogram===&lt;br /&gt;
There are no ECG findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An ECG may be helpful in the diagnosis of [disease name]. Findings on an ECG suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===X-ray===&lt;br /&gt;
There are no x-ray findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
An x-ray may be helpful in the diagnosis of [disease name]. Findings on an x-ray suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no x-ray findings associated with [disease name]. However, an x-ray may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Echocardiography or Ultrasound===&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Echocardiography/ultrasound  may be helpful in the diagnosis of [disease name]. Findings on an echocardiography/ultrasound suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no echocardiography/ultrasound  findings associated with [disease name]. However, an echocardiography/ultrasound  may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===CT scan===&lt;br /&gt;
There are no CT scan findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] CT scan may be helpful in the diagnosis of [disease name]. Findings on CT scan suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no CT scan findings associated with [disease name]. However, a CT scan may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===MRI===&lt;br /&gt;
There are no MRI findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].&lt;br /&gt;
&lt;br /&gt;
===Other Imaging Findings===&lt;br /&gt;
There are no other imaging findings associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
===Other Diagnostic Studies===&lt;br /&gt;
There are no other diagnostic studies associated with [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].&lt;br /&gt;
==Treatment==&lt;br /&gt;
===Medical Therapy===&lt;br /&gt;
There is no treatment for [disease name]; the mainstay of therapy is supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Supportive therapy for [disease name] includes [therapy 1], [therapy 2], and [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The majority of cases of [disease name] are self-limited and require only supportive care.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Disease name] is a medical emergency and requires prompt treatment.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is [therapy].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
 &lt;br /&gt;
The optimal therapy for [malignancy name] depends on the stage at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Therapy] is recommended among all patients who develop [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapy is recommended among patients with [disease subclass 1], [disease subclass 2], and [disease subclass 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Pharmacologic medical therapies for [disease name] include (either) [therapy 1], [therapy 2], and/or [therapy 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Empiric therapy for [disease name] depends on [disease factor 1] and [disease factor 2].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Patients with [disease subclass 1] are treated with [therapy 1], whereas patients with [disease subclass 2] are treated with [therapy 2].&lt;br /&gt;
&lt;br /&gt;
===Surgery===&lt;br /&gt;
Surgical intervention is not recommended for the management of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either [indication 1], [indication 2], and [indication 3]&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either [indication 1], [indication 2], and/or [indication 3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
The feasibility of surgery depends on the stage of [malignancy] at diagnosis.&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Surgery is the mainstay of treatment for [disease or malignancy].&lt;br /&gt;
&lt;br /&gt;
===Primary Prevention===&lt;br /&gt;
There are no established measures for the primary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
There are no available vaccines against [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
[Vaccine name] vaccine is recommended for [patient population] to prevent [disease name]. Other primary prevention strategies include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
===Secondary Prevention===&lt;br /&gt;
There are no established measures for the secondary prevention of [disease name].&lt;br /&gt;
&lt;br /&gt;
OR&lt;br /&gt;
&lt;br /&gt;
Effective measures for the secondary prevention of [disease name] include [strategy 1], [strategy 2], and [strategy 3].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{reflist|2}}&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Polyuria]]&lt;br /&gt;
* [[Enuresis]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Symptoms]]&lt;br /&gt;
[[Category:Signs and symptoms]]&lt;br /&gt;
[[Category:Geriatrics]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Urinary_incontinence_secondary_prevention&amp;diff=1673254</id>
		<title>Urinary incontinence secondary prevention</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Urinary_incontinence_secondary_prevention&amp;diff=1673254"/>
		<updated>2020-11-01T00:55:27Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: Created page with &amp;quot;__NOTOC__ {{Urinary incontinence}}  Please help WikiDoc by adding content here. It&amp;#039;s easy! Click here to learn about editing.   {{CMG}}; {{NN}}  ==...&amp;quot;&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Urinary incontinence}}&lt;br /&gt;
&lt;br /&gt;
Please help WikiDoc by adding content here. It&#039;s easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
{{CMG}}; {{NN}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
Secondary prevention strategies following [[urinary incontinence]] include reversing the predisposing factors and preventing the disease progression by beginning early treatment.&lt;br /&gt;
&lt;br /&gt;
==Secondary prevention in Urinary incontinence==&lt;br /&gt;
*Secondary prevention strategies following [[urinary incontinence]] include&amp;lt;ref name=&amp;quot;pmid9883256&amp;quot;&amp;gt;{{cite journal| author=Fonda D, Resnick NM, Kirschner-Hermanns R| title=Prevention of urinary incontinence in older people. | journal=Br J Urol | year= 1998 | volume= 82 Suppl 1 | issue=  | pages= 5-10 | pmid=9883256 | doi=10.1046/j.1464-410x.1998.0820s1005.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=9883256  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**reversing the predisposing factors&lt;br /&gt;
***increasing access to toilets&lt;br /&gt;
***asking about [[urinary incontinence]] symptoms from patients after high-risk medical conditions such as [[hip]] fracture and [[stroke]]&lt;br /&gt;
**preventing the disease progression by beginning early treatment with [[medications]] and [[mobility]]&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
{{WH}}&lt;br /&gt;
{{WS}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Needs content]]&lt;br /&gt;
[[Category:Kidney diseases]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
[[Category:Needs English Review]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Urinary_incontinence_natural_history,_complications_and_prognosis&amp;diff=1673253</id>
		<title>Urinary incontinence natural history, complications and prognosis</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Urinary_incontinence_natural_history,_complications_and_prognosis&amp;diff=1673253"/>
		<updated>2020-11-01T00:24:41Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Urinary incontinence}}&lt;br /&gt;
&lt;br /&gt;
Please help WikiDoc by adding content here. It&#039;s easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
{{CMG}}; {{NN}}&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==Complications==&lt;br /&gt;
*One of four women with [[urinary incontinence]] looks for treatment. &amp;lt;ref name=&amp;quot;pmid22527544&amp;quot;&amp;gt;{{cite journal| author=Minassian VA, Yan X, Lichtenfeld MJ, Sun H, Stewart WF| title=The iceberg of health care utilization in women with urinary incontinence. | journal=Int Urogynecol J | year= 2012 | volume= 23 | issue= 8 | pages= 1087-93 | pmid=22527544 | doi=10.1007/s00192-012-1743-x | pmc=3905313 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22527544  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**Common causes of low follow up rate in patients with [[urinary incontinence]] include&amp;lt;ref name=&amp;quot;pmid11145628&amp;quot;&amp;gt;{{cite journal| author=Shaw C, Tansey R, Jackson C, Hyde C, Allan R| title=Barriers to help seeking in people with urinary symptoms. | journal=Fam Pract | year= 2001 | volume= 18 | issue= 1 | pages= 48-52 | pmid=11145628 | doi=10.1093/fampra/18.1.48 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=11145628  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
***insufficient information about available therapeutic options&lt;br /&gt;
***considering [[urinary incontinence]] as a normal symptom of aging&lt;br /&gt;
***inaccessible medical intervention&lt;br /&gt;
***feeling embarrassed about [[urinary]] problems  &lt;br /&gt;
*Pure stress or urgency [[urinary incontinence]] are usually milder than mixed [[urinary incontinence]]. &amp;lt;ref name=&amp;quot;pmid18528608&amp;quot;&amp;gt;{{cite journal| author=Minassian VA, Stewart WF, Hirsch AG| title=Why do stress and urge incontinence co-occur much more often than expected? | journal=Int Urogynecol J Pelvic Floor Dysfunct | year= 2008 | volume= 19 | issue= 10 | pages= 1429-40 | pmid=18528608 | doi=10.1007/s00192-008-0647-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18528608  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid18491026&amp;quot;&amp;gt;{{cite journal| author=Dooley Y, Lowenstein L, Kenton K, FitzGerald M, Brubaker L| title=Mixed incontinence is more bothersome than pure incontinence subtypes. | journal=Int Urogynecol J Pelvic Floor Dysfunct | year= 2008 | volume= 19 | issue= 10 | pages= 1359-62 | pmid=18491026 | doi=10.1007/s00192-008-0637-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=18491026  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Common complications of [[urinary incontinence]] include &amp;lt;ref name=&amp;quot;pmid28471525&amp;quot;&amp;gt;{{cite journal| author=Gibson W, Hunter KF, Camicioli R, Booth J, Skelton DA, Dumoulin C | display-authors=etal| title=The association between lower urinary tract symptoms and falls: Forming a theoretical model for a research agenda. | journal=Neurourol Urodyn | year= 2018 | volume= 37 | issue= 1 | pages= 501-509 | pmid=28471525 | doi=10.1002/nau.23295 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=28471525  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid16086679&amp;quot;&amp;gt;{{cite journal| author=Hu TW, Wagner TH| title=Health-related consequences of overactive bladder: an economic perspective. | journal=BJU Int | year= 2005 | volume= 96 Suppl 1 | issue=  | pages= 43-5 | pmid=16086679 | doi=10.1111/j.1464-410X.2005.05654.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=16086679  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**increased risk of falling and [[fractures]]&lt;br /&gt;
**[[urinary tract infection]]&lt;br /&gt;
**sleep disorders&lt;br /&gt;
**[[depression]]&lt;br /&gt;
* However, psychological and social problems may arise, particularly if one is unable to get to the bathroom when there is urge.&lt;br /&gt;
&lt;br /&gt;
==Prognosis==&lt;br /&gt;
*The prognosis associated with [[urinary incontinence]] depends on the underlying cause and associated conditions such as accurate diagnosis, and proper treatment.&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
{{WH}}&lt;br /&gt;
{{WS}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Needs overview]]&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Needs content]]&lt;br /&gt;
[[Category:Needs English Review]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Urinary_incontinence_historical_perspective&amp;diff=1673250</id>
		<title>Urinary incontinence historical perspective</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Urinary_incontinence_historical_perspective&amp;diff=1673250"/>
		<updated>2020-10-31T22:55:26Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Urinary incontinence}}&lt;br /&gt;
{{CMG}}; {{NN}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
[[urinary incontinence]] was first described by ancient Egyptians in 1500 BC that resulted from [[spinal cord injury]]. Leonardo da Vinci (1452-1519) described the [[internal sphincter]] at the neck of the [[bladder]] in his drawings. In 1564, several portable urinals was developed by Ambros Pare to treat [[urinary incontinence]] in males. In the 1600s, the condom [[catheter]] with pig [[bladder]] was first designed by Wilhem Hildanus. In 1747, a [[perineal]] bulbar [[urethral]] compression belt was first innovated by Lorenz Heister. In 1988, Botulinum toxin A [Botox] was introduced for [[detrusor]] [[sphincter]] disorder secondary to [[spinal cord injury]]. In 1929, the modern [[urethral]] [[catheter]] was first developed by Frederic Foley to control postoperative [[bleeding]] after [[suprapubic]] prostatectomies.&lt;br /&gt;
== Historical Perspective==&lt;br /&gt;
* [[urinary incontinence]] was first described by ancient Egyptians in 1500 BC that resulted from [[spinal cord injury]]. &amp;lt;ref name=&amp;quot;pmid29053886&amp;quot;&amp;gt;{{cite journal| author=Chong JT, Simma-Chiang V| title=A historical perspective and evolution of the treatment of male urinary incontinence. | journal=Neurourol Urodyn | year= 2018 | volume= 37 | issue= 3 | pages= 1169-1175 | pmid=29053886 | doi=10.1002/nau.23429 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29053886  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Leonardo da Vinci (1452-1519) described the [[internal sphincter]] at the neck of the [[bladder]] in his drawings.&amp;lt;ref name=&amp;quot;pmid10418086&amp;quot;&amp;gt;{{cite journal| author=Schultheiss D, Grünewald V, Jonas U| title=Urodynamics in the anatomical work of Leonardo da Vinci (1452-1519). | journal=World J Urol | year= 1999 | volume= 17 | issue= 3 | pages= 137-43 | pmid=10418086 | doi=10.1007/s003450050121 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10418086  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*In 1564, several portable urinals was developed by Ambros Pare to treat [[urinary incontinence]] in males. &amp;lt;ref name=&amp;quot;pmid10940713&amp;quot;&amp;gt;{{cite journal| author=Schultheiss D, Höfner K, Oelke M, Grünewald V, Jonas U| title=Historical aspects of the treatment of urinary incontinence. | journal=Eur Urol | year= 2000 | volume= 38 | issue= 3 | pages= 352-62 | pmid=10940713 | doi=10.1159/000020306 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10940713  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*In the 1600s, the condom [[catheter]] with pig [[bladder]] was first designed by Wilhem Hildanus. &amp;lt;ref name=&amp;quot;pmid10940713&amp;quot;&amp;gt;{{cite journal| author=Schultheiss D, Höfner K, Oelke M, Grünewald V, Jonas U| title=Historical aspects of the treatment of urinary incontinence. | journal=Eur Urol | year= 2000 | volume= 38 | issue= 3 | pages= 352-62 | pmid=10940713 | doi=10.1159/000020306 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10940713  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*In 1747, a [[perineal]] bulbar [[urethral]] compression belt was first innovated by Lorenz Heister. &amp;lt;ref name=&amp;quot;pmid29053886&amp;quot;&amp;gt;{{cite journal| author=Chong JT, Simma-Chiang V| title=A historical perspective and evolution of the treatment of male urinary incontinence. | journal=Neurourol Urodyn | year= 2018 | volume= 37 | issue= 3 | pages= 1169-1175 | pmid=29053886 | doi=10.1002/nau.23429 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29053886  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
===Landmark Events in the Development of Treatment Strategies===&lt;br /&gt;
*In the 17-19th centuries, some natural [[medications]] with [[anticholinergic]] and [[antidiuretic]] effects including [[opium]], [[strychnine]], and [[atropine]] were introduced as a therapeutic strategy for [[urge incontinence]]. &amp;lt;ref name=&amp;quot;pmid29053886&amp;quot;&amp;gt;{{cite journal| author=Chong JT, Simma-Chiang V| title=A historical perspective and evolution of the treatment of male urinary incontinence. | journal=Neurourol Urodyn | year= 2018 | volume= 37 | issue= 3 | pages= 1169-1175 | pmid=29053886 | doi=10.1002/nau.23429 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29053886  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*In 1858, [[carbonic acid]] with [[chloroform]] was used by J.Rhodes to treat [[nocturnal incontinence]] in an old man. &amp;lt;ref name=&amp;quot;urlIncontinence of Urine Treated by the Local Application of Carbonic Acid Gas with Chloroform&amp;quot;&amp;gt;{{cite web |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2251305/ |title=Incontinence of Urine Treated by the Local Application of Carbonic Acid Gas with Chloroform |format= |work= |accessdate=}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*In 1929, the modern [[urethral]] [[catheter]] was first developed by Frederic Foley to control postoperative [[bleeding]] after [[suprapubic]] prostatectomies.&lt;br /&gt;
*In 1962, [[reflexive therapy]] was introduced by T. Dickson for [[ urge incontinence]] secondary to [[neurogenic bladder]]. &amp;lt;ref name=&amp;quot;pmid29053886&amp;quot;&amp;gt;{{cite journal| author=Chong JT, Simma-Chiang V| title=A historical perspective and evolution of the treatment of male urinary incontinence. | journal=Neurourol Urodyn | year= 2018 | volume= 37 | issue= 3 | pages= 1169-1175 | pmid=29053886 | doi=10.1002/nau.23429 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29053886  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*In the late 19th , Robert Gersuny treated [[urinary incontinence]] with injecting paraffin into the [[urethra]] and [[periurethral]] areas. &amp;lt;ref name=&amp;quot;pmid29053886&amp;quot;&amp;gt;{{cite journal| author=Chong JT, Simma-Chiang V| title=A historical perspective and evolution of the treatment of male urinary incontinence. | journal=Neurourol Urodyn | year= 2018 | volume= 37 | issue= 3 | pages= 1169-1175 | pmid=29053886 | doi=10.1002/nau.23429 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=29053886  }} &amp;lt;/ref&amp;gt;&amp;lt;ref name=&amp;quot;pmid10940713&amp;quot;&amp;gt;{{cite journal| author=Schultheiss D, Höfner K, Oelke M, Grünewald V, Jonas U| title=Historical aspects of the treatment of urinary incontinence. | journal=Eur Urol | year= 2000 | volume= 38 | issue= 3 | pages= 352-62 | pmid=10940713 | doi=10.1159/000020306 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=10940713  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*Others injectable bulking agents have been found for curing the [[urinary incontinence]], including &amp;lt;ref name=&amp;quot;pmid929773&amp;quot;&amp;gt;{{cite journal| author=Heer H| title=[Treatment of Urinary incontinence by Teflon injection (author&#039;s transl)]. | journal=Urol Int | year= 1977 | volume= 32 | issue= 4 | pages= 295-302 | pmid=929773 | doi=10.1159/000280145 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=929773  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15332628&amp;quot;&amp;gt;{{cite journal| author=Jordan O, Doelker E, Defabiani N, Caviezel A, Iselin C| title=Novel injectable urethral bulking agents for the treatment of urinary incontinence. | journal=J Mater Sci Mater Med | year= 2004 | volume= 15 | issue= 4 | pages= 519-22 | pmid=15332628 | doi=10.1023/b:jmsm.0000021131.15283.18 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15332628  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid22435469&amp;quot;&amp;gt;{{cite journal| author=Yamamoto T, Gotoh M, Kato M, Majima T, Toriyama K, Kamei Y | display-authors=etal| title=Periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress urinary incontinence: Report of three initial cases. | journal=Int J Urol | year= 2012 | volume= 19 | issue= 7 | pages= 652-9 | pmid=22435469 | doi=10.1111/j.1442-2042.2012.02999.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=22435469  }} &amp;lt;/ref&amp;gt; &amp;lt;ref name=&amp;quot;pmid15247778&amp;quot;&amp;gt;{{cite journal| author=Thornton AJ, Alsberg E, Hill EE, Mooney DJ| title=Shape retaining injectable hydrogels for minimally invasive bulking. | journal=J Urol | year= 2004 | volume= 172 | issue= 2 | pages= 763-8 | pmid=15247778 | doi=10.1097/01.ju.0000130466.84214.f7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=15247778  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
**[[Teflon]]&lt;br /&gt;
**[[collagen]] &lt;br /&gt;
**autologous [[adipose tissue]] &lt;br /&gt;
**cross-linked [[silicone]] gels &lt;br /&gt;
*Since 20th century, new [[urethral]] injection therapies such as [[stem cell]] therapy have been developed for treating [[urinary incontinence]].&lt;br /&gt;
*In 1988, [[Botulinum toxin]] A ([[Botox]]) was introduced for [[detrusor]] [[sphincter]] disorder secondary to [[spinal cord injury]]. &amp;lt;ref name=&amp;quot;pmid3361663&amp;quot;&amp;gt;{{cite journal| author=Dykstra DD, Sidi AA, Scott AB, Pagel JM, Goldish GD| title=Effects of botulinum A toxin on detrusor-sphincter dyssynergia in spinal cord injury patients. | journal=J Urol | year= 1988 | volume= 139 | issue= 5 | pages= 919-22 | pmid=3361663 | doi=10.1016/s0022-5347(17)42717-0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=3361663  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
*After FDA approval of [[Botox]] injection in 2011, it has been used for treating [[urinary incontinence]] in [[neurogenic]] [[detrusor overactivity]] and patients who cannot tolerate [[anticholinergic]] [[medications]]. &amp;lt;ref name=&amp;quot;pmid23941788&amp;quot;&amp;gt;{{cite journal| author=Linsenmeyer TA| title=Use of botulinum toxin in individuals with neurogenic detrusor overactivity: state of the art review. | journal=J Spinal Cord Med | year= 2013 | volume= 36 | issue= 5 | pages= 402-19 | pmid=23941788 | doi=10.1179/2045772313Y.0000000116 | pmc=3739890 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&amp;amp;tool=sumsearch.org/cite&amp;amp;retmode=ref&amp;amp;cmd=prlinks&amp;amp;id=23941788  }} &amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
===Development of Treatment Strategies===&lt;br /&gt;
&lt;br /&gt;
==References==&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Urinary_incontinence_primary_prevention&amp;diff=1672471</id>
		<title>Urinary incontinence primary prevention</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Urinary_incontinence_primary_prevention&amp;diff=1672471"/>
		<updated>2020-10-28T11:06:13Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&lt;br /&gt;
__NOTOC__&lt;br /&gt;
{{Urinary incontinence}}&lt;br /&gt;
&lt;br /&gt;
Please help WikiDoc by adding content here. It&#039;s easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
{{CMG}}; {{NN}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
[[pelvic]] floor muscle training in the early pregnancy may prevent [[urinary incontinence]] in the late [[antenatal]] and [[postpartum]]. Other effective measures for the primary prevention of [[urinary incontinence]] include increase [[physical activity]] and exercises, [[weight loss]], stop [[smoking]], treating [[asthma]] and [[constipation]], proper management during labor to avoid [[pelvic organ prolapse]] and [[urogenital injury]].&lt;br /&gt;
&lt;br /&gt;
==Primary Prevention in urinary incontinence ==&lt;br /&gt;
* [[pelvic]] floor muscle training such as [[kegel]] exercise in the early pregnancy may prevent [[urinary incontinence]] in the late [[antenatal]] and [[postpartum]]. &amp;lt;ref name=&amp;quot;WoodleyBoyle2017&amp;quot;&amp;gt;{{cite journal|last1=Woodley|first1=Stephanie J|last2=Boyle|first2=Rhianon|last3=Cody|first3=June D|last4=Mørkved|first4=Siv|last5=Hay-Smith|first5=E Jean C|title=Pelvic floor muscle training for prevention and treatment of urinary and faecal incontinence in antenatal and postnatal women|journal=Cochrane Database of Systematic Reviews|year=2017|issn=14651858|doi=10.1002/14651858.CD007471.pub3}}&amp;lt;/ref&amp;gt;So, it can be suggested to women during pregnancy and after delivery. &amp;lt;ref name=&amp;quot;SoaveScarani2019&amp;quot;&amp;gt;{{cite journal|last1=Soave|first1=Ilaria|last2=Scarani|first2=Simona|last3=Mallozzi|first3=Maddalena|last4=Nobili|first4=Flavia|last5=Marci|first5=Roberto|last6=Caserta|first6=Donatella|title=Pelvic floor muscle training for prevention and treatment of urinary incontinence during pregnancy and after childbirth and its effect on urinary system and supportive structures assessed by objective measurement techniques|journal=Archives of Gynecology and Obstetrics|volume=299|issue=3|year=2019|pages=609–623|issn=0932-0067|doi=10.1007/s00404-018-5036-6}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*Other effective measures for the primary prevention of [[urinary incontinence]] include:&amp;lt;ref name=&amp;quot;KisslerYount2016&amp;quot;&amp;gt;{{cite journal|last1=Kissler|first1=Katherine|last2=Yount|first2=Susan M.|last3=Rendeiro|first3=Melissa|last4=Zeidenstein|first4=Laura|title=Primary Prevention of Urinary Incontinence: A Case Study of Prenatal and Intrapartum Interventions|journal=Journal of Midwifery &amp;amp; Women&#039;s Health|volume=61|issue=4|year=2016|pages=507–511|issn=15269523|doi=10.1111/jmwh.12420}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**increase [[physical activity]] and exercises&lt;br /&gt;
** [[weight loss]]&lt;br /&gt;
**stop [[smoking]]&lt;br /&gt;
** treating [[asthma]] and [[constipation]]&lt;br /&gt;
** proper management during [[labor]] to reduce [[complications]] such as [[pelvic organ prolapse]] and [[urogenital injury]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
{{WH}}&lt;br /&gt;
{{WS}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Needs content]]&lt;br /&gt;
[[Category:Kidney diseases]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
[[Category:Needs English Review]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Urinary_incontinence_primary_prevention&amp;diff=1672470</id>
		<title>Urinary incontinence primary prevention</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Urinary_incontinence_primary_prevention&amp;diff=1672470"/>
		<updated>2020-10-28T11:05:00Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: Created page with &amp;quot; __NOTOC__ {{Urinary incontinence}}  Please help WikiDoc by adding content here. It&amp;#039;s easy! Click here to learn about editing.     {{CMG}}; {{NN}}...&amp;quot;&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;&lt;br /&gt;
__NOTOC__&lt;br /&gt;
{{Urinary incontinence}}&lt;br /&gt;
&lt;br /&gt;
Please help WikiDoc by adding content here. It&#039;s easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing. &lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
{{CMG}}; {{NN}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
[[pelvic]] floor muscle training in the early pregnancy may prevent [[urinary incontinence]] in the late [[antenatal]] and [[postpartum]]. Other effective measures for the primary prevention of [[urinary incontinence]] include increase [[physical activity]] and exercises, [[weight loss]], stop [[smoking]], treating [[asthma]] and [[constipation]], proper management during labor to avoid [[pelvic organ prolapse]] and [[urogenital injury]].&lt;br /&gt;
&lt;br /&gt;
==Primary Prevention in urinary incontinence ==&lt;br /&gt;
* [[pelvic]] floor muscle training such as [[kegel]] exercise in the early pregnancy may prevent [[urinary incontinence]] in the late [[antenatal]] and [[postpartum]]. &amp;lt;ref name=&amp;quot;WoodleyBoyle2017&amp;quot;&amp;gt;{{cite journal|last1=Woodley|first1=Stephanie J|last2=Boyle|first2=Rhianon|last3=Cody|first3=June D|last4=Mørkved|first4=Siv|last5=Hay-Smith|first5=E Jean C|title=Pelvic floor muscle training for prevention and treatment of urinary and faecal incontinence in antenatal and postnatal women|journal=Cochrane Database of Systematic Reviews|year=2017|issn=14651858|doi=10.1002/14651858.CD007471.pub3}}&amp;lt;/ref&amp;gt;So, it can be suggested to women during pregnancy and after delivery. &amp;lt;ref name=&amp;quot;SoaveScarani2019&amp;quot;&amp;gt;{{cite journal|last1=Soave|first1=Ilaria|last2=Scarani|first2=Simona|last3=Mallozzi|first3=Maddalena|last4=Nobili|first4=Flavia|last5=Marci|first5=Roberto|last6=Caserta|first6=Donatella|title=Pelvic floor muscle training for prevention and treatment of urinary incontinence during pregnancy and after childbirth and its effect on urinary system and supportive structures assessed by objective measurement techniques|journal=Archives of Gynecology and Obstetrics|volume=299|issue=3|year=2019|pages=609–623|issn=0932-0067|doi=10.1007/s00404-018-5036-6}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
*Other effective measures for the primary prevention of [[urinary incontinence]] include:&amp;lt;ref name=&amp;quot;KisslerYount2016&amp;quot;&amp;gt;{{cite journal|last1=Kissler|first1=Katherine|last2=Yount|first2=Susan M.|last3=Rendeiro|first3=Melissa|last4=Zeidenstein|first4=Laura|title=Primary Prevention of Urinary Incontinence: A Case Study of Prenatal and Intrapartum Interventions|journal=Journal of Midwifery &amp;amp; Women&#039;s Health|volume=61|issue=4|year=2016|pages=507–511|issn=15269523|doi=10.1111/jmwh.12420}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**increase [[physical activity]] and exercises&lt;br /&gt;
** [[weight loss]]&lt;br /&gt;
**stop [[smoking]]&lt;br /&gt;
** treating [[asthma]] and [[constipation]]&lt;br /&gt;
** proper management during labor to avoid [[pelvic organ prolapse]] and [[urogenital injury]]&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
{{WH}}&lt;br /&gt;
{{WS}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Needs content]]&lt;br /&gt;
[[Category:Kidney diseases]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
[[Category:Needs English Review]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Urinary_incontinence_screening&amp;diff=1672467</id>
		<title>Urinary incontinence screening</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Urinary_incontinence_screening&amp;diff=1672467"/>
		<updated>2020-10-28T10:03:56Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: Created page with &amp;quot;__NOTOC__ {{Urinary incontinence}}  Please help WikiDoc by adding content here. It&amp;#039;s easy! Click here to learn about editing.   {{CMG}}; {{NN}}  ==...&amp;quot;&lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Urinary incontinence}}&lt;br /&gt;
&lt;br /&gt;
Please help WikiDoc by adding content here. It&#039;s easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
{{CMG}}; {{NN}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
According to the Women&#039;s Preventive Services Initiative (WPSI), screening for [[urinary incontinence]] is recommended every year among women.&lt;br /&gt;
==Screening in urinary incontinence ==&lt;br /&gt;
* According to the Women&#039;s Preventive Services Initiative (WPSI), screening for [[urinary incontinence]] is recommended every year among women. &amp;lt;ref name=&amp;quot;O&#039;ReillyNelson2018&amp;quot;&amp;gt;{{cite journal|last1=O&#039;Reilly|first1=Nancy|last2=Nelson|first2=Heidi D.|last3=Conry|first3=Jeanne M.|last4=Frost|first4=Jennifer|last5=Gregory|first5=Kimberly D.|last6=Kendig|first6=Susan M.|last7=Phipps|first7=Maureen|last8=Salganicoff|first8=Alina|last9=Ramos|first9=Diana|last10=Zahn|first10=Christopher|last11=Qaseem|first11=Amir|title=Screening for Urinary Incontinence in Women: A Recommendation From the Women&#039;s Preventive Services Initiative|journal=Annals of Internal Medicine|volume=169|issue=5|year=2018|pages=320|issn=0003-4819|doi=10.7326/M18-0595}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
**Screening includes asking questions from women about [[urinary incontinence]] [[symptoms]], identifying the type and severity of [[incontinence]] and recognizing functional impairment and its effect on quality of life. &amp;lt;ref name=&amp;quot;O&#039;ReillyNelson2018&amp;quot;&amp;gt;{{cite journal|last1=O&#039;Reilly|first1=Nancy|last2=Nelson|first2=Heidi D.|last3=Conry|first3=Jeanne M.|last4=Frost|first4=Jennifer|last5=Gregory|first5=Kimberly D.|last6=Kendig|first6=Susan M.|last7=Phipps|first7=Maureen|last8=Salganicoff|first8=Alina|last9=Ramos|first9=Diana|last10=Zahn|first10=Christopher|last11=Qaseem|first11=Amir|title=Screening for Urinary Incontinence in Women: A Recommendation From the Women&#039;s Preventive Services Initiative|journal=Annals of Internal Medicine|volume=169|issue=5|year=2018|pages=320|issn=0003-4819|doi=10.7326/M18-0595}}&amp;lt;/ref&amp;gt;&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
{{WH}}&lt;br /&gt;
{{WS}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Needs content]]&lt;br /&gt;
[[Category:Kidney diseases]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
[[Category:Needs English Review]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
	<entry>
		<id>https://www.wikidoc.org/index.php?title=Urinary_incontinence_x_ray&amp;diff=1672460</id>
		<title>Urinary incontinence x ray</title>
		<link rel="alternate" type="text/html" href="https://www.wikidoc.org/index.php?title=Urinary_incontinence_x_ray&amp;diff=1672460"/>
		<updated>2020-10-28T09:14:43Z</updated>

		<summary type="html">&lt;p&gt;NNikravangolsefid: &lt;/p&gt;
&lt;hr /&gt;
&lt;div&gt;__NOTOC__&lt;br /&gt;
{{Urinary incontinence}}&lt;br /&gt;
&lt;br /&gt;
Please help WikiDoc by adding content here. It&#039;s easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
{{CMG}}; {{NN}}&lt;br /&gt;
&lt;br /&gt;
==Overview==&lt;br /&gt;
There are no x-ray findings associated with [[urinary incontinence]]&lt;br /&gt;
&lt;br /&gt;
==Key X-Ray Findings in urinary incontinence ==&lt;br /&gt;
*There are no x-ray findings associated with [[urinary incontinence]].&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
==References==&lt;br /&gt;
{{Reflist|2}}&lt;br /&gt;
{{WH}}&lt;br /&gt;
{{WS}}&lt;br /&gt;
&lt;br /&gt;
[[Category:Urology]]&lt;br /&gt;
[[Category:Needs content]]&lt;br /&gt;
[[Category:Kidney diseases]]&lt;br /&gt;
[[Category:Disease]]&lt;br /&gt;
[[Category:Needs English Review]]&lt;/div&gt;</summary>
		<author><name>NNikravangolsefid</name></author>
	</entry>
</feed>