https://www.wikidoc.org/api.php?action=feedcontributions&feedformat=atom&user=Faizan+Sherazwikidoc - User contributions [en]2026-04-07T21:58:58ZUser contributionsMediaWiki 1.45.1https://www.wikidoc.org/index.php?title=User:Faizan_Sheraz&diff=1478964User:Faizan Sheraz2018-06-24T04:23:56Z<p>Faizan Sheraz: </p>
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<div>__NOTOC__<br />
==Faizan Sheraz==<br />
'''Faizan Sheraz, MD,MBBS'''<br />
<br />
'''Associate Editor in Chief'''<br />
'''Email:'''faizansheraz@wikidoc.org<br />
<br />
==Current Position==<br />
* Post-doctoral Research Fellow Intern at Perfuse Study Group and Associate editor in Chief at wikidoc.org<br />
**Harvard medical school/Beth Israel Deaconess Medical Center, Boston, MA.<br />
<br />
==Education==<br />
Army Medical college, MBBS.<br />
==Brief Biography==<br />
Dr. Sheraz was born in twin city of Islamabad, Pakistan. He graduated from Army Medical College in 2013 and did his internship at Social Security Hospital Islamabad. He has written various research articles which were published in Journal of Pakistan Medical association, International Journal of archives, Journal of physicians and surgeons Pakistan and Journal of American College of Gastroenterology.<br />
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==Publications==<br />
===Peer Reviewed Journal Articles/Abstracts===<br />
*Saad, M.M., Ullah, S., Sheraz, F., Dharamshi, H.A. Breast cancer prevention and role of the general physician. Journal of Pakistan Medical Association. 2015, Jul; 65(07): 801. Pub Status: Published.<br />
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===Peer Reviewed Journal Articles/Abstracts(Other than Published)===<br />
*Dharamshi, H.A., Kumar, A., Sheraz, F.. Remote Controlling and Monitoring of Microscopic slides. Medical Journal of The Islamic Republic of Iran (MJIRI). 2015, Jun; Pub Status: Accepted.<br />
*Dharamshi, H.A., Sheraz, F.. Just a cup or care. Journal of Pakistan Medical Association. 2015, May; Pub Status: Accepted.<br />
*Dharamshi, H.A., Sheraz, F.. Life of Medical Professionals in Pakistan. Journal of Pakistan Medical Association. 2015, Jul; Pub Status: Accepted.<br />
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*Dharamshi, H.A., Sheraz,F.. Electronic smoke. Journal of Pakistan Medical Association/. 2015, Jun; Pub Status: Accepted.<br />
*Hussain, H., Hussain, S.S., Ullah, S., Sheraz, F., Faraz, A.. Cephalic Tetanus. International Journal of Archives/. 2015, May; Pub Status: Provisionally Accepted.<br />
*Sheraz, F., Tahir, H.. Addisonian crisis causing Rhabdomyolysis and acute renal failure. Journal of college of physicians and surgeons Pakistan. 2015, Aug; Pub Status: Submitted.<br />
*Sheraz, F., Tahir, H., Sagi, J., Daruwalla, V.. Dengue fever presenting atypically with viral conjunctivitis and subacute Thyroiditis. Journal of College of physician and surgeons Pakistan. 2015, Jun; Pub Status: Provisionally Accepted.<br />
*Tahir, H., Sheraz, F., Sagi, J., Daruwalla, V.. Immune Thrombocytopenia(ITP) secondary to Subclinical Hashimoto’s Thyroiditis: Role of Levothyroxine in improving the Clinical Outcome of ITP. British Medical Journal. 2015, May; Pub Status: Submitted.<br />
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==Poster Presentation==<br />
*Dharamshi, H.A., Faraz, A., Sheraz, F., Ullah, S., Rehman, M.. (2015). Poster presented at: The Future of Ethics in Medicine Second European Conference on Ethics, Religion & Philosophy 2015 Brighton, United Kingdom, July 6-8, 2015; Brighton, GBR.<br />
*Sheraz, F., Awan, A.A.Y.. (2015). Poster presented at: American A Case of Gastric Duplication Cyst Mimicking Staghorn Calculus College of Gastroenterology 80th Scientific Meeting; Honolulu, HI.<br />
*Sheraz, F., Dharamshi, H.A., Ullah, Saad.. (2015). Variation of Hepatic Enzymes With Vitamin B12 and Vitamin D3 Levels in Cirrhotic Poster presented at: American College of Gastroenterology 80th Scientific Meeting; Honolulu, HI.Patients<br />
===Oral Presentation===<br />
*Sheraz, F., Zafar, M.. (2010). Oral Presentation presented Frequency of Asthma in medical students of Army Medical College, Pakistan. at: Army medical College Annual Symposium 2010, Pakistan.; Rawalpindi, PAK</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_natural_history,_complications_and_prognosis&diff=1207259Desmoid tumor natural history, complications and prognosis2016-01-26T20:13:57Z<p>Faizan Sheraz: ←Redirected page to Desmoid tumor natural history, complications, and prognosis</p>
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<div>#redirect[[Desmoid tumor natural history, complications, and prognosis]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor&diff=1207258Desmoid tumor2016-01-26T20:12:34Z<p>Faizan Sheraz: /* Diagnosis */</p>
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<div>'''For patient information click [[{{PAGENAME}} (patient information)|here]]<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
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{{SK}} Aggressive fibromatosis, deep musculoaponeurotic fibromatosis<br />
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==[[Desmoid tumor overview|Overview]]==<br />
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==[[Desmoid tumor historical perspective|Historical Perspective]]==<br />
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==[[Desmoid tumor classification|Classification]]==<br />
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==[[Desmoid tumor pathophysiology|Pathophysiology]]==<br />
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==[[Desmoid tumor causes|Causes]]==<br />
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==[[Desmoid tumor differential diagnosis|Differentiating Laryngeal cancer from other Diseases]]==<br />
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==[[Desmoid tumor epidemiology and demographics|Epidemiology and Demographics]]==<br />
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==[[Desmoid tumor risk factors|Risk Factors]]==<br />
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==[[Desmoid tumor natural history, complications and prognosis|Natural History, Complications and Prognosis]]==<br />
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==Diagnosis==<br />
[[Desmoid tumor history and symptoms|History and Symptoms]] | [[Desmoid tumor physical examination|Physical Examination]] |[[Desmoid tumor laboratory tests|Laboratory Findings]] | [[Desmoid tumor CT|CT]] | [[Desmoid tumor MRI|MRI]] | [[Desmoid tumor other imaging findings|Other Imaging Findings]] | [[Desmoid tumor other diagnostic studies|Other Diagnostic Studies]]<br />
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==Treatment==<br />
[[Desmoid tumor medical therapy|Medical Therapy]] | [[Desmoid tumor surgery|Surgery]] | [[Desmoid tumor cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Desmoid tumor future or investigational therapies|Future or Investigational Therapies]]<br />
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==Case Studies==<br />
[[Desmoid tumor case study one|Case #1]]<br />
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{{tumors}}<br />
<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
<br />
[[Category:Disease]]<br />
[[Category:Oncology]]<br />
[[Category:Types of cancer]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor&diff=1207256Desmoid tumor2016-01-26T20:12:00Z<p>Faizan Sheraz: /* Diagnosis */</p>
<hr />
<div>'''For patient information click [[{{PAGENAME}} (patient information)|here]]<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
<br />
{{SK}} Aggressive fibromatosis, deep musculoaponeurotic fibromatosis<br />
<br />
==[[Desmoid tumor overview|Overview]]==<br />
<br />
==[[Desmoid tumor historical perspective|Historical Perspective]]==<br />
<br />
==[[Desmoid tumor classification|Classification]]==<br />
<br />
==[[Desmoid tumor pathophysiology|Pathophysiology]]==<br />
<br />
==[[Desmoid tumor causes|Causes]]==<br />
<br />
==[[Desmoid tumor differential diagnosis|Differentiating Laryngeal cancer from other Diseases]]==<br />
<br />
==[[Desmoid tumor epidemiology and demographics|Epidemiology and Demographics]]==<br />
<br />
==[[Desmoid tumor risk factors|Risk Factors]]==<br />
<br />
==[[Desmoid tumor natural history, complications and prognosis|Natural History, Complications and Prognosis]]==<br />
<br />
==Diagnosis==<br />
[[Desmoid tumor history and symptoms|History and Symptoms]] | [[Desmoid tumor physical examination|Physical Examination]] |[[Desmoid tumor laboratory tests|Laboratory Findings]] | [[Desmoid tumor electrocardiogram|Electrocardiogram]] | [[Desmoid tumor chest x ray|Chest X Ray]] | [[Desmoid tumor CT|CT]] | [[Desmoid tumor MRI|MRI]] | [[Desmoid tumor other imaging findings|Other Imaging Findings]] | [[Desmoid tumor other diagnostic studies|Other Diagnostic Studies]]<br />
<br />
==Treatment==<br />
[[Desmoid tumor medical therapy|Medical Therapy]] | [[Desmoid tumor surgery|Surgery]] | [[Desmoid tumor cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Desmoid tumor future or investigational therapies|Future or Investigational Therapies]]<br />
<br />
==Case Studies==<br />
[[Desmoid tumor case study one|Case #1]]<br />
<br />
{{tumors}}<br />
<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
<br />
[[Category:Disease]]<br />
[[Category:Oncology]]<br />
[[Category:Types of cancer]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_classification&diff=1207254Desmoid tumor classification2016-01-26T20:09:19Z<p>Faizan Sheraz: /* Classification */</p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Classification==<br />
Desmoid tumor may be classified as follows:<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
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{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center<br />
|valign=top|<br />
|+<br />
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Classification}}<br />
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Features}}<br />
|-<br />
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |<br />
Extraabdominal<br />
| style="padding: 5px 5px; background: #F5F5F5;" |<br />
Desmoid tumor may involve:<br />
*Shoulder girdle<br />
*Trunk<br />
*Lower extremities<br />
|-<br />
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |<br />
Intraabdominal<br />
| style="padding: 5px 5px; background: #F5F5F5;" |<br />
*[[Mesentery]]<br />
*[[Retroperitoneum]]<br />
|-<br />
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |<br />
Multiple Familial<br />
| style="padding: 5px 5px; background: #F5F5F5;" |<br />
*Hereditary predisposition<br />
|-<br />
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |<br />
[[Gardner Syndrome]] Associated<br />
| style="padding: 5px 5px; background: #F5F5F5;" |<br />
*Soft tissue tumors<br />
*[[Osteoma]]<br />
|-<br />
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |<br />
[[Turcot Syndrome]] Associated<br />
| style="padding: 5px 5px; background: #F5F5F5;" |<br />
*Neural tumors<br />
|}<br />
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==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1207251Desmoid tumor overview2016-01-26T20:06:22Z<p>Faizan Sheraz: /* Diagnosis */</p>
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<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Aggressive fibromatosis is a rare condition marked by the presence of desmoid tumors. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout the body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines. Fibroblasts also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. When they are aggressive they can cause life threatening problems or even death due to compression of vital organs such as the intestines, kidneys, lungs, blood vessels, and nerves. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
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==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
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==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
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==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
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==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
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==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera, and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the least favorable prognosis.<br />
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==Diagnosis==<br />
===History and Symptoms===<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
===Physical Examination===<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
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===CT===<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by a well circumscribed mass that is homogeneously or focally hyperattenuating. Desmoid tumor may demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
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===MRI===<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
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===Other Imaging Findings===<br />
Other imaging findings of desmoid tumor include ultrasonography, which demonstrates tumor size and location. On ultrasonography, desmoid tumors appear as well-defined lesions with variable echogenicity. The lateral borders may appear ill defined or irregular.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
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==Treatment==<br />
===Medical Therapy===<br />
Medical therapy for desmoid tumor includes [[antiestrogen]]s (ex. [[tamoxifen]]), [[non-steroidal anti-inflammatory drug|NSAIDs]], [[chemotherapy]] or microwave ablation.<br />
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===Surgery===<br />
Surgical resection is not recommended among patients with advanced or metastatic [[malignancy]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_CT&diff=1207249Desmoid tumor CT2016-01-26T20:03:54Z<p>Faizan Sheraz: /* CT */</p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by a well circumscribed mass that is homogeneously or focally hyperattenuating. Desmoid tumor may demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==CT==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by a well circumscribed mass that may:<br />
*Appear more aggressive with ill-defined margins<br />
*Be homogeneously or focally hyperattenuating when compared to soft tissue on the non-contrast scan<br />
*Demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
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<gallery>Rectus-abdominis-muscle-desmoid-tumour.jpg | Desmoid tumor of rectus abdominis muscle</gallery><br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_CT&diff=1207248Desmoid tumor CT2016-01-26T20:01:49Z<p>Faizan Sheraz: /* Overview */</p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by a well circumscribed mass that is homogeneously or focally hyperattenuating. Desmoid tumor may demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==CT==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by:<br />
*Well circumscribed mass, although in some cases it may appear more aggressive with ill-defined margins.<br />
*Homogeneously or focally hyperattenuating when compared to soft tissue on the non-contrast scan.<br />
*Most will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
<gallery>Rectus-abdominis-muscle-desmoid-tumour.jpg | Desmoid tumor of rectus abdominis muscle</gallery><br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
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{{WikiDoc Sources}}<br />
[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1207247Desmoid tumor overview2016-01-26T19:59:32Z<p>Faizan Sheraz: /* Overview */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Aggressive fibromatosis is a rare condition marked by the presence of desmoid tumors. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout the body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines. Fibroblasts also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. When they are aggressive they can cause life threatening problems or even death due to compression of vital organs such as the intestines, kidneys, lungs, blood vessels, and nerves. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
<br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera, and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the least favorable prognosis.<br />
<br />
==Diagnosis==<br />
===History and Symptoms===<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
===Physical Examination===<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
===CT===<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by well circumscribed mass, homogeneously or focally hyperattenuating, and tumor that will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
===MRI===<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
===Other Imaging Findings===<br />
Other imaging findings of desmoid tumor include ultrasonography, which demonstrates tumor size and location. On ultrasonography, desmoid tumors appear as well-defined lesions with variable echogenicity. The lateral borders may appear ill defined or irregular.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Treatment==<br />
===Medical Therapy===<br />
Medical therapy for desmoid tumor includes [[antiestrogen]]s (ex. [[tamoxifen]]), [[non-steroidal anti-inflammatory drug|NSAIDs]], [[chemotherapy]] or microwave ablation.<br />
<br />
===Surgery===<br />
Surgical resection is not recommended among patients with advanced or metastatic [[malignancy]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1207243Desmoid tumor overview2016-01-26T19:54:31Z<p>Faizan Sheraz: </p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Aggressive fibromatosis is a rare condition marked by the presence of desmoid tumors. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
<br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera, and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the least favorable prognosis.<br />
<br />
==Diagnosis==<br />
===History and Symptoms===<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
===Physical Examination===<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
===CT===<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by well circumscribed mass, homogeneously or focally hyperattenuating, and tumor that will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
===MRI===<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
===Other Imaging Findings===<br />
Other imaging findings of desmoid tumor include ultrasonography, which demonstrates tumor size and location. On ultrasonography, desmoid tumors appear as well-defined lesions with variable echogenicity. The lateral borders may appear ill defined or irregular.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Treatment==<br />
===Medical Therapy===<br />
Medical therapy for desmoid tumor includes [[antiestrogen]]s (ex. [[tamoxifen]]), [[non-steroidal anti-inflammatory drug|NSAIDs]], [[chemotherapy]] or microwave ablation.<br />
<br />
===Surgery===<br />
Surgical resection is not recommended among patients with advanced or metastatic [[malignancy]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1207233Desmoid tumor overview2016-01-26T19:45:42Z<p>Faizan Sheraz: </p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Aggressive fibromatosis is a rare condition marked by the presence of desmoid tumors. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
<br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera, and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the least favorable prognosis.<br />
<br />
==History and Symptoms==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
==Physical Examination==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==CT==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by well circumscribed mass, homogeneously or focally hyperattenuating, and tumor that will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==MRI==<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Other Imaging Findings==<br />
Other imaging findings of desmoid tumor include ultrasonography, which demonstrates tumor size and location. On ultrasonography, desmoid tumors appear as well-defined lesions with variable echogenicity. The lateral borders may appear ill defined or irregular.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Medical Therapy==<br />
Medical therapy for desmoid tumor includes [[antiestrogen]]s (ex. [[tamoxifen]]), [[non-steroidal anti-inflammatory drug|NSAIDs]], [[chemotherapy]] or microwave ablation.<br />
<br />
==Surgery==<br />
Surgical resection is not recommended among patients with advanced or metastatic [[malignancy]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Reference==<br />
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[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor&diff=1207231Desmoid tumor2016-01-26T19:42:44Z<p>Faizan Sheraz: </p>
<hr />
<div>'''For patient information click [[{{PAGENAME}} (patient information)|here]]<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
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{{SK}} Aggressive fibromatosis, deep musculoaponeurotic fibromatosis<br />
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==[[Desmoid tumor overview|Overview]]==<br />
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==[[Desmoid tumor historical perspective|Historical Perspective]]==<br />
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==[[Desmoid tumor classification|Classification]]==<br />
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==[[Desmoid tumor pathophysiology|Pathophysiology]]==<br />
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==[[Desmoid tumor causes|Causes]]==<br />
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==[[Desmoid tumor differential diagnosis|Differentiating Laryngeal cancer from other Diseases]]==<br />
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==[[Desmoid tumor epidemiology and demographics|Epidemiology and Demographics]]==<br />
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==[[Desmoid tumor risk factors|Risk Factors]]==<br />
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==[[Desmoid tumor natural history, complications and prognosis|Natural History, Complications and Prognosis]]==<br />
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==Diagnosis==<br />
[[Desmoid tumor staging|Staging]] | [[Desmoid tumor history and symptoms|History and Symptoms]] | [[Desmoid tumor physical examination|Physical Examination]] |[[Desmoid tumor laboratory tests|Laboratory Findings]] | [[Desmoid tumor electrocardiogram|Electrocardiogram]] | [[Desmoid tumor chest x ray|Chest X Ray]] | [[Desmoid tumor CT|CT]] | [[Desmoid tumor MRI|MRI]] | [[Desmoid tumor echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Desmoid tumor other imaging findings|Other Imaging Findings]] | [[Desmoid tumor other diagnostic studies|Other Diagnostic Studies]]<br />
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==Treatment==<br />
[[Desmoid tumor medical therapy|Medical Therapy]] | [[Desmoid tumor surgery|Surgery]] | [[Desmoid tumor cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Desmoid tumor future or investigational therapies|Future or Investigational Therapies]]<br />
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==Case Studies==<br />
[[Desmoid tumor case study one|Case #1]]<br />
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{{tumors}}<br />
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[[Category:Disease]]<br />
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[[Category:Types of cancer]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_medical_therapy&diff=1207228Desmoid tumor medical therapy2016-01-26T19:41:46Z<p>Faizan Sheraz: </p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Medical therapy for desmoid tumor includes [[antiestrogen]]s (ex. [[tamoxifen]]), [[non-steroidal anti-inflammatory drug|NSAIDs]], [[chemotherapy]], or microwave ablation.<br />
<br />
==Medical Therapy==<br />
Medical therapy for prolactinoma includes:<ref name="pmid22359346">{{cite journal |author=Wilkinson MJ, Fitzgerald JE, Thomas JM, Hayes AJ, Strauss DC|title=Surgical resection for non-familial adenomatous polyposis-related intra-abdominal fibromatosis |journal=BJS. |volume=99 |issue=5 |pages=706–13|year=2012 |doi=10.1002/bjs.8703 |pmid=22359346}}</ref><ref name="pmid22370045">{{cite journal| author=Rammohan A, Wood JJ| title=Desmoid tumour of the breast as a manifestation of Gardner's syndrome. | journal=Int J Surg Case Rep | year= 2012 | volume= 3 | issue= 5 | pages= 139-42 | pmid=22370045 | doi=10.1016/j.ijscr.2012.01.004 | pmc=PMC3312056 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22370045 }} </ref><br />
*[[Antiestrogen]]s (ex. [[Tamoxifen]])<br />
*[[Non-steroidal anti-inflammatory drug|NSAIDs]]<br />
*[[Chemotherapy]]<br />
*Microwave ablation<br />
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==Radiation Therapy==<br />
Rarely, [[radiation therapy]] is used if medical therapy and [[surgery]] fail. Depending on the size and location of the [[tumor]], [[radiation]] is delivered either in low doses over the course of 5 to 6 weeks or in a single high dose. [[Radiation]] therapy is effective in approximately 30% of cases.<br />
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==Reference==<br />
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[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_laboratory_tests&diff=1207226Desmoid tumor laboratory tests2016-01-26T19:40:51Z<p>Faizan Sheraz: </p>
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<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
Please help WikiDoc by adding content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing.<br />
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==Reference==<br />
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[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_other_diagnostic_studies&diff=1207224Desmoid tumor other diagnostic studies2016-01-26T19:40:27Z<p>Faizan Sheraz: </p>
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<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
Please help WikiDoc by adding content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing.<br />
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==Reference==<br />
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[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_MRI&diff=1207223Desmoid tumor MRI2016-01-26T19:39:50Z<p>Faizan Sheraz: /* MRI */</p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
==MRI==<br />
Abdominal MRI may be diagnostic of desmoid tumor. Its appearance is characterized by their dense cellularity. Typical signal characteristics include:<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
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{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center<br />
|valign=top|<br />
|+<br />
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|MRI Component}}<br />
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Features}}<br />
|-<br />
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |<br />
:T1<br />
| style="padding: 5px 5px; background: #F5F5F5;" |<br />
*Low signal intensity<br />
|-<br />
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |<br />
:T1 C+ (Gd)<br />
| style="padding: 5px 5px; background: #F5F5F5;" |<br />
*May show homogeneous, inhomogeneous, or no significant enhancement<br />
|-<br />
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |<br />
:T2<br />
| style="padding: 5px 5px; background: #F5F5F5;" |<br />
*Low signal intensity<br />
|}<br />
<gallery>MRI_desmoid_T1_fl2d_FS.jpg | MRI of desmoid tumor<ref name=aa>Desmoid Tumor mri. https://en.wikipedia.org/wiki/Aggressive_fibromatosis#/media/File:MRI_desmoid_T1_fl2d_FS.jpg</ref></gallery><br />
<br />
==Reference==<br />
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[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_laboratory_tests&diff=1207216Desmoid tumor laboratory tests2016-01-26T19:34:49Z<p>Faizan Sheraz: </p>
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<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
Please help WikiDoc by adding content here. It's easy! Click [[Help:How_to_Edit_a_Page|here]] to learn about editing.<br />
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==Reference==<br />
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[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_physical_examination&diff=1207214Desmoid tumor physical examination2016-01-26T19:34:03Z<p>Faizan Sheraz: /* Physical Examination */</p>
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<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Physical Examination==<br />
*Patients with desmoid tumors are usually normal in appearance. <br />
*Common physical examination findings of desmoid tumor include:<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
:*Abdominal tenderness<br />
:*Elevated temperature<br />
:*[[Pallor]]<br />
:*Weight changes<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_physical_examination&diff=1207208Desmoid tumor physical examination2016-01-26T19:32:50Z<p>Faizan Sheraz: /* Physical Examination */</p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Physical Examination==<br />
*Patients with desmoid tumors are usually normal in appearance. <br />
*Abdominal desmoid tumor usually presents as a mass that is sometimes associated with:<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
:*Abdominal tenderness<br />
:*Elevated temperature<br />
:*[[Pallor]]<br />
:*Weight changes<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
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[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_history_and_symptoms&diff=1207205Desmoid tumor history and symptoms2016-01-26T19:31:43Z<p>Faizan Sheraz: /* History and Symptoms */</p>
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<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
==History and Symptoms==<br />
Desmoid tumors are usually asymptomatic for a long period of time or can cause pain. Common symptoms include:<ref name="Słowik-MoczydłowskaRogulski2015">{{cite journal|last1=Słowik-Moczydłowska|first1=Żaneta|last2=Rogulski|first2=Robert|last3=Piotrowska|first3=Anna|last4=Małdyk|first4=Jadwiga|last5=Kluge|first5=Przemysław|last6=Kamiński|first6=Andrzej|title=Desmoid tumor of the pancreas: a case report|journal=Journal of Medical Case Reports|volume=9|issue=1|year=2015|issn=1752-1947|doi=10.1186/s13256-015-0591-y}}</ref><br />
*Abdominal mass<br />
*Abdominal pain<br />
*[[Nausea]]<br />
*[[Vomiting]]<br />
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==Reference==<br />
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[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_natural_history,_complications,_and_prognosis&diff=1207202Desmoid tumor natural history, complications, and prognosis2016-01-26T19:30:53Z<p>Faizan Sheraz: </p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera, and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the least favorable prognosis.<br />
<br />
==Natural history==<br />
*If left untreated, desmoid tumor produces few symptoms early in the course.<br />
<br />
==Complications==<br />
Common complications of desmoid tumor include:<br />
*Progression to aggressive fibromatosis<br />
*Involvement of intra abdominal organs<br />
*[[Metastasis]]<br />
<br />
==Prognosis==<br />
Desmoid tumor associated with familial adenomatous polyposis has the most unfavorable prognosis.<br />
<br />
==Reference==<br />
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[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_natural_history,_complications,_and_prognosis&diff=1207200Desmoid tumor natural history, complications, and prognosis2016-01-26T19:30:32Z<p>Faizan Sheraz: /* Overview */</p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera, and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the least favorable prognosis.<br />
<br />
==Natural history==<br />
*If left untreated, desmoid tumor produces few symptoms early in the course.<br />
<br />
==Complications==<br />
Common complications of desmoid tumor include:<br />
*Progression to aggressive fibromatosis<br />
*Involvement of intra abdominal organs<br />
*[[Metastasis]]<br />
<br />
==Prognosis==<br />
Desmoid tumor associated with familial adenomatous polyposis has the most unfavorable prognosis.<br />
<br />
<br />
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<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
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[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1207199Desmoid tumor overview2016-01-26T19:29:49Z<p>Faizan Sheraz: /* Natural History, Complications and Prognosis */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Aggressive fibromatosis is a rare condition marked by the presence of desmoid tumors. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
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==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
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==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera, and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the least favorable prognosis.<br />
<br />
==History and Symptoms==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
==Physical Examination==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Laboratory Findings==<br />
==CT==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by well circumscribed mass, homogeneously or focally hyperattenuating, and tumor that will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==MRI==<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Other Imaging Findings==<br />
Other imaging findings of desmoid tumor include ultrasonography, which demonstrates tumor size and location. On ultrasonography, desmoid tumors appear as well-defined lesions with variable echogenicity. The lateral borders may appear ill defined or irregular.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Medical Therapy==<br />
Medical therapy for desmoid tumor includes [[antiestrogen]]s (ex. [[tamoxifen]]), [[non-steroidal anti-inflammatory drug|NSAIDs]], [[chemotherapy]] or microwave ablation.<br />
<br />
==Surgery==<br />
Surgical resection is not recommended among patients with advanced or metastatic [[malignancy]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Reference==<br />
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{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1207198Desmoid tumor overview2016-01-26T19:29:22Z<p>Faizan Sheraz: /* Natural History, Complications and Prognosis */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Aggressive fibromatosis is a rare condition marked by the presence of desmoid tumors. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
<br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera, and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the most unfavorable prognosis.<br />
<br />
==History and Symptoms==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
==Physical Examination==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Laboratory Findings==<br />
==CT==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by well circumscribed mass, homogeneously or focally hyperattenuating, and tumor that will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==MRI==<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Other Imaging Findings==<br />
Other imaging findings of desmoid tumor include ultrasonography, which demonstrates tumor size and location. On ultrasonography, desmoid tumors appear as well-defined lesions with variable echogenicity. The lateral borders may appear ill defined or irregular.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Medical Therapy==<br />
Medical therapy for desmoid tumor includes [[antiestrogen]]s (ex. [[tamoxifen]]), [[non-steroidal anti-inflammatory drug|NSAIDs]], [[chemotherapy]] or microwave ablation.<br />
<br />
==Surgery==<br />
Surgical resection is not recommended among patients with advanced or metastatic [[malignancy]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_natural_history,_complications,_and_prognosis&diff=1207196Desmoid tumor natural history, complications, and prognosis2016-01-26T19:28:54Z<p>Faizan Sheraz: /* Overview */</p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera, and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the most unfavorable prognosis.<br />
<br />
==Natural history==<br />
*If left untreated, desmoid tumor produces few symptoms early in the course.<br />
<br />
==Complications==<br />
Common complications of desmoid tumor include:<br />
*Progression to aggressive fibromatosis<br />
*Involvement of intra abdominal organs<br />
*[[Metastasis]]<br />
<br />
==Prognosis==<br />
Desmoid tumor associated with familial adenomatous polyposis has the most unfavorable prognosis.<br />
<br />
<br />
<br />
<br />
<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_risk_factors&diff=1207194Desmoid tumor risk factors2016-01-26T19:27:58Z<p>Faizan Sheraz: /* Risk Factors */</p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Common risk factors for the development of desmoid tumor include an APC mutation 3' to codon 1399, previous abdominal surgery, and the female sex.<ref name="JenayahBettaieb2015">{{cite journal|last1=Jenayah|first1=Amel Achour|last2=Bettaieb|first2=Hajer|last3=Saoudi|first3=Sarra|last4=Gharsa|first4=Anissa|last5=Sfar|first5=Ezzeddine|last6=Boudaya|first6=Fethia|last7=Chelli|first7=Dalenda|title=Desmoid tumors: clinical features and treatment options: a case report and a review of literature|journal=Pan African Medical Journal|volume=21|year=2015|issn=1937-8688|doi=10.11604/pamj.2015.21.93.7037}}</ref><br />
<br />
==Risk Factors==<br />
Common risk factors for the development of desmoid tumor include:<ref name="JenayahBettaieb2015">{{cite journal|last1=Jenayah|first1=Amel Achour|last2=Bettaieb|first2=Hajer|last3=Saoudi|first3=Sarra|last4=Gharsa|first4=Anissa|last5=Sfar|first5=Ezzeddine|last6=Boudaya|first6=Fethia|last7=Chelli|first7=Dalenda|title=Desmoid tumors: clinical features and treatment options: a case report and a review of literature|journal=Pan African Medical Journal|volume=21|year=2015|issn=1937-8688|doi=10.11604/pamj.2015.21.93.7037}}</ref><br />
*APC mutation 3' to codon 1399<br />
*Previous abdominal surgery<br />
*Female gender<br />
<br />
==Reference==<br />
{{Reflist|1}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_risk_factors&diff=1207191Desmoid tumor risk factors2016-01-26T19:27:33Z<p>Faizan Sheraz: </p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Common risk factors for the development of desmoid tumor include an APC mutation 3' to codon 1399, previous abdominal surgery, and the female sex.<ref name="JenayahBettaieb2015">{{cite journal|last1=Jenayah|first1=Amel Achour|last2=Bettaieb|first2=Hajer|last3=Saoudi|first3=Sarra|last4=Gharsa|first4=Anissa|last5=Sfar|first5=Ezzeddine|last6=Boudaya|first6=Fethia|last7=Chelli|first7=Dalenda|title=Desmoid tumors: clinical features and treatment options: a case report and a review of literature|journal=Pan African Medical Journal|volume=21|year=2015|issn=1937-8688|doi=10.11604/pamj.2015.21.93.7037}}</ref><br />
<br />
==Risk Factors==<br />
Common risk factors for the development of desmoid tumor include:<ref name="JenayahBettaieb2015">{{cite journal|last1=Jenayah|first1=Amel Achour|last2=Bettaieb|first2=Hajer|last3=Saoudi|first3=Sarra|last4=Gharsa|first4=Anissa|last5=Sfar|first5=Ezzeddine|last6=Boudaya|first6=Fethia|last7=Chelli|first7=Dalenda|title=Desmoid tumors: clinical features and treatment options: a case report and a review of literature|journal=Pan African Medical Journal|volume=21|year=2015|issn=1937-8688|doi=10.11604/pamj.2015.21.93.7037}}</ref><br />
*APC mutation 3' to codon 1399<br />
*Previous abdominal surgery<br />
*Female sex<br />
<br />
==Reference==<br />
{{Reflist|1}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_epidemiology_and_demographics&diff=1207190Desmoid tumor epidemiology and demographics2016-01-26T19:26:54Z<p>Faizan Sheraz: </p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Epidemiology and Demographics==<br />
===Prevalence===<br />
Desmoid tumor occurs in less than 0.03% of all tumors.<br />
===Incidence===<br />
The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><br />
<br />
===Gender===<br />
Females are more commonly affected with desmoid tumor than males.<br />
<br />
===Age===<br />
Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_epidemiology_and_demographics&diff=1207187Desmoid tumor epidemiology and demographics2016-01-26T19:26:32Z<p>Faizan Sheraz: </p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Epidemiology and Demographics==<br />
===Prevalence===<br />
Desmoid tumor occurs in less than 0.03% of all tumors.<br />
===Incidence===<br />
The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><br />
<br />
===Gender===<br />
Females are more commonly affected with desmoid tumor than males.<br />
<br />
===Age===<br />
Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><br />
<br />
==Reference==<br />
{{Reflist|1}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_causes&diff=1207185Desmoid tumor causes2016-01-26T19:25:47Z<p>Faizan Sheraz: </p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
There are no established causes for desmoid tumor.<br />
==Causes==<br />
There are no established causes for desmoid tumor.<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Deep_musculoaponeurotic_fibromatosis&diff=1206983Deep musculoaponeurotic fibromatosis2016-01-26T16:30:05Z<p>Faizan Sheraz: ←Redirected page to Desmoid tumor</p>
<hr />
<div>#redirect[[desmoid tumor]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor&diff=1206981Desmoid tumor2016-01-26T16:29:12Z<p>Faizan Sheraz: </p>
<hr />
<div>'''For patient information click [[{{PAGENAME}} (patient information)|here]]<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
<br />
{{SK}} Aggressive fibromatosis, deep musculoaponeurotic fibromatosis<br />
<br />
==[[Desmoid tumor overview|Overview]]==<br />
<br />
==[[Desmoid tumor historical perspective|Historical Perspective]]==<br />
<br />
==[[Desmoid tumor classification|Classification]]==<br />
<br />
==[[Desmoid tumor pathophysiology|Pathophysiology]]==<br />
<br />
==[[Desmoid tumor causes|Causes]]==<br />
<br />
==[[Desmoid tumor differential diagnosis|Differentiating Laryngeal cancer from other Diseases]]==<br />
<br />
==[[Desmoid tumor epidemiology and demographics|Epidemiology and Demographics]]==<br />
<br />
==[[Desmoid tumor risk factors|Risk Factors]]==<br />
<br />
==[[Desmoid tumor screening|Screening]]==<br />
<br />
==[[Desmoid tumor natural history, complications and prognosis|Natural History, Complications and Prognosis]]==<br />
<br />
==Diagnosis==<br />
[[Desmoid tumor staging|Staging]] | [[Desmoid tumor history and symptoms|History and Symptoms]] | [[Desmoid tumor physical examination|Physical Examination]] |[[Desmoid tumor laboratory tests|Laboratory Findings]] | [[Desmoid tumor electrocardiogram|Electrocardiogram]] | [[Desmoid tumor chest x ray|Chest X Ray]] | [[Desmoid tumor CT|CT]] | [[Desmoid tumor MRI|MRI]] | [[Desmoid tumor echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Desmoid tumor other imaging findings|Other Imaging Findings]] | [[Desmoid tumor other diagnostic studies|Other Diagnostic Studies]]<br />
<br />
==Treatment==<br />
[[Desmoid tumor medical therapy|Medical Therapy]] | [[Desmoid tumor surgery|Surgery]] | [[Desmoid tumor cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Desmoid tumor future or investigational therapies|Future or Investigational Therapies]]<br />
<br />
==Case Studies==<br />
[[Desmoid tumor case study one|Case #1]]<br />
<br />
{{tumors}}<br />
<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
<br />
[[Category:Disease]]<br />
[[Category:Oncology]]<br />
[[Category:Types of cancer]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor&diff=1206976Desmoid tumor2016-01-26T16:26:25Z<p>Faizan Sheraz: </p>
<hr />
<div>'''For patient information click [[{{PAGENAME}} (patient information)|here]]<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
<br />
{{SK}} Aggressive fibromatosis<br />
<br />
==[[Desmoid tumor overview|Overview]]==<br />
<br />
==[[Desmoid tumor historical perspective|Historical Perspective]]==<br />
<br />
==[[Desmoid tumor classification|Classification]]==<br />
<br />
==[[Desmoid tumor pathophysiology|Pathophysiology]]==<br />
<br />
==[[Desmoid tumor causes|Causes]]==<br />
<br />
==[[Desmoid tumor differential diagnosis|Differentiating Laryngeal cancer from other Diseases]]==<br />
<br />
==[[Desmoid tumor epidemiology and demographics|Epidemiology and Demographics]]==<br />
<br />
==[[Desmoid tumor risk factors|Risk Factors]]==<br />
<br />
==[[Desmoid tumor screening|Screening]]==<br />
<br />
==[[Desmoid tumor natural history, complications and prognosis|Natural History, Complications and Prognosis]]==<br />
<br />
==Diagnosis==<br />
[[Desmoid tumor staging|Staging]] | [[Desmoid tumor history and symptoms|History and Symptoms]] | [[Desmoid tumor physical examination|Physical Examination]] |[[Desmoid tumor laboratory tests|Laboratory Findings]] | [[Desmoid tumor electrocardiogram|Electrocardiogram]] | [[Desmoid tumor chest x ray|Chest X Ray]] | [[Desmoid tumor CT|CT]] | [[Desmoid tumor MRI|MRI]] | [[Desmoid tumor echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Desmoid tumor other imaging findings|Other Imaging Findings]] | [[Desmoid tumor other diagnostic studies|Other Diagnostic Studies]]<br />
<br />
==Treatment==<br />
[[Desmoid tumor medical therapy|Medical Therapy]] | [[Desmoid tumor surgery|Surgery]] | [[Desmoid tumor cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Desmoid tumor future or investigational therapies|Future or Investigational Therapies]]<br />
<br />
==Case Studies==<br />
[[Desmoid tumor case study one|Case #1]]<br />
<br />
{{tumors}}<br />
<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
<br />
[[Category:Disease]]<br />
[[Category:Oncology]]<br />
[[Category:Types of cancer]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor&diff=1206975Desmoid tumor2016-01-26T16:25:21Z<p>Faizan Sheraz: </p>
<hr />
<div>'''For patient information click [[{{PAGENAME}} (patient information)|here]]<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
<br />
{{SK}} Aggressive fibromatosis, fibromatosis<br />
<br />
==[[Desmoid tumor overview|Overview]]==<br />
<br />
==[[Desmoid tumor historical perspective|Historical Perspective]]==<br />
<br />
==[[Desmoid tumor classification|Classification]]==<br />
<br />
==[[Desmoid tumor pathophysiology|Pathophysiology]]==<br />
<br />
==[[Desmoid tumor causes|Causes]]==<br />
<br />
==[[Desmoid tumor differential diagnosis|Differentiating Laryngeal cancer from other Diseases]]==<br />
<br />
==[[Desmoid tumor epidemiology and demographics|Epidemiology and Demographics]]==<br />
<br />
==[[Desmoid tumor risk factors|Risk Factors]]==<br />
<br />
==[[Desmoid tumor screening|Screening]]==<br />
<br />
==[[Desmoid tumor natural history, complications and prognosis|Natural History, Complications and Prognosis]]==<br />
<br />
==Diagnosis==<br />
[[Desmoid tumor staging|Staging]] | [[Desmoid tumor history and symptoms|History and Symptoms]] | [[Desmoid tumor physical examination|Physical Examination]] |[[Desmoid tumor laboratory tests|Laboratory Findings]] | [[Desmoid tumor electrocardiogram|Electrocardiogram]] | [[Desmoid tumor chest x ray|Chest X Ray]] | [[Desmoid tumor CT|CT]] | [[Desmoid tumor MRI|MRI]] | [[Desmoid tumor echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Desmoid tumor other imaging findings|Other Imaging Findings]] | [[Desmoid tumor other diagnostic studies|Other Diagnostic Studies]]<br />
<br />
==Treatment==<br />
[[Desmoid tumor medical therapy|Medical Therapy]] | [[Desmoid tumor surgery|Surgery]] | [[Desmoid tumor cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Desmoid tumor future or investigational therapies|Future or Investigational Therapies]]<br />
<br />
==Case Studies==<br />
[[Desmoid tumor case study one|Case #1]]<br />
<br />
{{tumors}}<br />
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{{WikiDoc Sources}}<br />
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[[Category:Disease]]<br />
[[Category:Oncology]]<br />
[[Category:Types of cancer]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1206973Desmoid tumor overview2016-01-26T16:24:10Z<p>Faizan Sheraz: /* Overview */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Aggressive fibromatosis is a rare condition marked by the presence of desmoid tumors. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
<br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the most unfavorable prognosis.<br />
<br />
==History and Symptoms==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
==Physical Examination==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Laboratory Findings==<br />
==CT==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by well circumscribed mass, homogeneously or focally hyperattenuating, and tumor that will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==MRI==<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Other Imaging Findings==<br />
Other imaging findings of desmoid tumor include ultrasonography, which demonstrates tumor size and location. On ultrasonography, desmoid tumors appear as well-defined lesions with variable echogenicity. The lateral borders may appear ill defined or irregular.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Medical Therapy==<br />
Medical therapy for desmoid tumor includes [[antiestrogen]]s (ex. [[tamoxifen]]), [[non-steroidal anti-inflammatory drug|NSAIDs]], [[chemotherapy]] or microwave ablation.<br />
<br />
==Surgery==<br />
Surgical resection is not recommended among patients with advanced or metastatic [[malignancy]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1206971Desmoid tumor overview2016-01-26T16:22:54Z<p>Faizan Sheraz: /* Surgery */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
'''Aggressive fibromatosis''' is a rare condition marked by the presence of '''desmoid tumors'''. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the most unfavorable prognosis.<br />
<br />
==History and Symptoms==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
==Physical Examination==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Laboratory Findings==<br />
==CT==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by well circumscribed mass, homogeneously or focally hyperattenuating, and tumor that will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==MRI==<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Other Imaging Findings==<br />
Other imaging findings of desmoid tumor include ultrasonography, which demonstrates tumor size and location. On ultrasonography, desmoid tumors appear as well-defined lesions with variable echogenicity. The lateral borders may appear ill defined or irregular.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Medical Therapy==<br />
Medical therapy for desmoid tumor includes [[antiestrogen]]s (ex. [[tamoxifen]]), [[non-steroidal anti-inflammatory drug|NSAIDs]], [[chemotherapy]] or microwave ablation.<br />
<br />
==Surgery==<br />
Surgical resection is not recommended among patients with advanced or metastatic [[malignancy]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1206970Desmoid tumor overview2016-01-26T16:22:08Z<p>Faizan Sheraz: /* Medical Therapy */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
'''Aggressive fibromatosis''' is a rare condition marked by the presence of '''desmoid tumors'''. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the most unfavorable prognosis.<br />
<br />
==History and Symptoms==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
==Physical Examination==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Laboratory Findings==<br />
==CT==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by well circumscribed mass, homogeneously or focally hyperattenuating, and tumor that will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==MRI==<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Other Imaging Findings==<br />
Other imaging findings of desmoid tumor include ultrasonography, which demonstrates tumor size and location. On ultrasonography, desmoid tumors appear as well-defined lesions with variable echogenicity. The lateral borders may appear ill defined or irregular.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Medical Therapy==<br />
Medical therapy for desmoid tumor includes [[antiestrogen]]s (ex. [[tamoxifen]]), [[non-steroidal anti-inflammatory drug|NSAIDs]], [[chemotherapy]] or microwave ablation.<br />
<br />
==Surgery==<br />
<br />
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<br />
<br />
<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_medical_therapy&diff=1206969Desmoid tumor medical therapy2016-01-26T16:21:43Z<p>Faizan Sheraz: </p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Medical therapy for desmoid tumor includes [[antiestrogen]]s (ex. [[tamoxifen]]), [[non-steroidal anti-inflammatory drug|NSAIDs]], [[chemotherapy]] or microwave ablation.<br />
<br />
==Medical Therapy==<br />
Medical therapy for prolactinoma includes:<ref name="pmid22359346">{{cite journal |author=Wilkinson MJ, Fitzgerald JE, Thomas JM, Hayes AJ, Strauss DC|title=Surgical resection for non-familial adenomatous polyposis-related intra-abdominal fibromatosis |journal=BJS. |volume=99 |issue=5 |pages=706–13|year=2012 |doi=10.1002/bjs.8703 |pmid=22359346}}</ref><ref name="pmid22370045">{{cite journal| author=Rammohan A, Wood JJ| title=Desmoid tumour of the breast as a manifestation of Gardner's syndrome. | journal=Int J Surg Case Rep | year= 2012 | volume= 3 | issue= 5 | pages= 139-42 | pmid=22370045 | doi=10.1016/j.ijscr.2012.01.004 | pmc=PMC3312056 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22370045 }} </ref><br />
*[[Antiestrogen]]s (ex. [[Tamoxifen]])<br />
*[[Non-steroidal anti-inflammatory drug|NSAIDs]]<br />
*[[Chemotherapy]]<br />
*Microwave ablation<br />
Current experimental studies are being done with Gleevec ([[Imatinib]]) and Nexavar ([[sorafenib]]) for treatment of desmoid tumors, and show promising success rates.<br />
<br />
==Radiation Therapy==<br />
Rarely, [[radiation therapy]] is used if medical therapy and [[surgery]] fail. Depending on the size and location of the [[tumor]], [[radiation]] is delivered either in low doses over the course of 5 to 6 weeks or in a single high dose. [[Radiation]] therapy is effective in approximately 30% of cases.<br />
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<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1206966Desmoid tumor overview2016-01-26T16:21:03Z<p>Faizan Sheraz: </p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
'''Aggressive fibromatosis''' is a rare condition marked by the presence of '''desmoid tumors'''. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the most unfavorable prognosis.<br />
<br />
==History and Symptoms==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
==Physical Examination==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Laboratory Findings==<br />
==CT==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by well circumscribed mass, homogeneously or focally hyperattenuating, and tumor that will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==MRI==<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Other Imaging Findings==<br />
Other imaging findings of desmoid tumor include ultrasonography, which demonstrates tumor size and location. On ultrasonography, desmoid tumors appear as well-defined lesions with variable echogenicity. The lateral borders may appear ill defined or irregular.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Medical Therapy==<br />
<br />
==Surgery==<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1206964Desmoid tumor overview2016-01-26T16:19:55Z<p>Faizan Sheraz: /* Other Imaging Findings */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
'''Aggressive fibromatosis''' is a rare condition marked by the presence of '''desmoid tumors'''. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
==Historical Perspective==<br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the most unfavorable prognosis.<br />
<br />
==History and Symptoms==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
==Physical Examination==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Laboratory Findings==<br />
==CT==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by well circumscribed mass, homogeneously or focally hyperattenuating, and tumor that will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==MRI==<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Other Imaging Findings==<br />
Other imaging findings of desmoid tumor include ultrasonography, which demonstrates tumor size and location. On ultrasonography, desmoid tumors appear as well-defined lesions with variable echogenicity. The lateral borders may appear ill defined or irregular.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Other Diagnostic Studies==<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1206958Desmoid tumor overview2016-01-26T16:17:34Z<p>Faizan Sheraz: /* MRI */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
'''Aggressive fibromatosis''' is a rare condition marked by the presence of '''desmoid tumors'''. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
==Historical Perspective==<br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the most unfavorable prognosis.<br />
<br />
==History and Symptoms==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
==Physical Examination==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Laboratory Findings==<br />
==CT==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by well circumscribed mass, homogeneously or focally hyperattenuating, and tumor that will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==MRI==<br />
Abdominal MRI may be diagnostic of desmoid tumor. On [[MRI]], desmoid tumor is characterized by dense cellularity and loss of signal following fat saturation.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Other Imaging Findings==<br />
==Other Diagnostic Studies==<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1206957Desmoid tumor overview2016-01-26T16:16:27Z<p>Faizan Sheraz: /* CT */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
'''Aggressive fibromatosis''' is a rare condition marked by the presence of '''desmoid tumors'''. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
==Historical Perspective==<br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the most unfavorable prognosis.<br />
<br />
==History and Symptoms==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
==Physical Examination==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Laboratory Findings==<br />
==CT==<br />
CT scan may be diagnostic for desmoid tumor. On CT scan, desmoid tumor is characterized by well circumscribed mass, homogeneously or focally hyperattenuating, and tumor that will demonstrate enhancement following administration of intravenous contrast.<ref name="radio"> Desmoid tumor. Radiopedia(2015) http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==MRI==<br />
==Other Imaging Findings==<br />
==Other Diagnostic Studies==<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1206953Desmoid tumor overview2016-01-26T16:15:37Z<p>Faizan Sheraz: /* Physical Examination */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
'''Aggressive fibromatosis''' is a rare condition marked by the presence of '''desmoid tumors'''. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
==Historical Perspective==<br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the most unfavorable prognosis.<br />
<br />
==History and Symptoms==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
==Physical Examination==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Laboratory Findings==<br />
==CT==<br />
==MRI==<br />
==Other Imaging Findings==<br />
==Other Diagnostic Studies==<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_physical_examination&diff=1206952Desmoid tumor physical examination2016-01-26T16:15:12Z<p>Faizan Sheraz: </p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Common physical examination findings of desmoid tumor include abdominal tenderness, pallor, and elevated temperature.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Physical Examination==<br />
*Patients with desmoid tumors are usually mormal in appearance. <br />
*Abdominal desmoid tumor usually presents as a mass that is sometimes associated with:<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
:*Abdominal tenderness<br />
:*Elevated temperature<br />
:*[[Pallor]]<br />
:*Weight changes<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_physical_examination&diff=1206950Desmoid tumor physical examination2016-01-26T16:12:29Z<p>Faizan Sheraz: /* Physical Examination */</p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Symptoms of desmoid tumor include [[fever]], [[vomiting]], [[weight loss]], and [[abdominal pain]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Physical Examination==<br />
*Patients with desmoid tumors are usually mormal in appearance. <br />
*Abdominal desmoid tumor usually presents as a mass that is sometimes associated with:<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
:*Abdominal tenderness<br />
:*Elevated temperature<br />
:*[[Pallor]]<br />
:*Weight changes<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_physical_examination&diff=1206948Desmoid tumor physical examination2016-01-26T16:11:48Z<p>Faizan Sheraz: /* Physical Examination */</p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Symptoms of desmoid tumor include [[fever]], [[vomiting]], [[weight loss]], and [[abdominal pain]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Physical Examination==<br />
*Desmoid tumors are usually asymptomatic. <br />
*Abdominal desmoid tumor usually presents as a mass that is sometimes associated with:<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
:*Abdominal tenderness<br />
:*Elevated temperature<br />
:*[[Pallor]]<br />
:*Weight changes<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1206945Desmoid tumor overview2016-01-26T16:09:15Z<p>Faizan Sheraz: /* History and Symptoms */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
'''Aggressive fibromatosis''' is a rare condition marked by the presence of '''desmoid tumors'''. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
==Historical Perspective==<br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the most unfavorable prognosis.<br />
<br />
==History and Symptoms==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
<br />
==Physical Examination==<br />
==Laboratory Findings==<br />
==CT==<br />
==MRI==<br />
==Other Imaging Findings==<br />
==Other Diagnostic Studies==<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_history_and_symptoms&diff=1206943Desmoid tumor history and symptoms2016-01-26T16:08:52Z<p>Faizan Sheraz: </p>
<hr />
<div>__NOTOC__<br />
{{Desmoid tumor}}<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
Symptoms of desmoid tumor include uncharacteristic pain, [[abdominal mass]], [[nausea]], and [[vomiting]].<br />
==History and Symptoms==<br />
Desmoid tumors are usually asymptomatic for a long period of time or can cause uncharacteristic pain as observed in our case. Common symptoms include:<ref name="Słowik-MoczydłowskaRogulski2015">{{cite journal|last1=Słowik-Moczydłowska|first1=Żaneta|last2=Rogulski|first2=Robert|last3=Piotrowska|first3=Anna|last4=Małdyk|first4=Jadwiga|last5=Kluge|first5=Przemysław|last6=Kamiński|first6=Andrzej|title=Desmoid tumor of the pancreas: a case report|journal=Journal of Medical Case Reports|volume=9|issue=1|year=2015|issn=1752-1947|doi=10.1186/s13256-015-0591-y}}</ref><br />
*Abdominal mass<br />
*Abdominal pain<br />
*[[Nausea]]<br />
*[[Vomiting]]<br />
<br />
<br />
<br />
<br />
<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Oncology]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1206942Desmoid tumor overview2016-01-26T16:08:04Z<p>Faizan Sheraz: /* Natural History, Complications and Prognosis */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
'''Aggressive fibromatosis''' is a rare condition marked by the presence of '''desmoid tumors'''. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
==Historical Perspective==<br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
If left untreated, desmoid tumor produces few symptoms early in the course. Common complications of desmoid tumor include progression to agressive fibromatosis, involvement of intra abdominal viscera and metastasis. The prognosis varies with the associated disease of desmoid tumor. Desmoid tumor associated with FAP has the most unfavorable prognosis.<br />
<br />
==History and Symptoms==<br />
==Physical Examination==<br />
==Laboratory Findings==<br />
==CT==<br />
==MRI==<br />
==Other Imaging Findings==<br />
==Other Diagnostic Studies==<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sherazhttps://www.wikidoc.org/index.php?title=Desmoid_tumor_overview&diff=1206940Desmoid tumor overview2016-01-26T16:07:07Z<p>Faizan Sheraz: /* Epidemiology and Demographics */</p>
<hr />
<div>{{Desmoid tumor}}<br />
__NOTOC__<br />
{{CMG}} {{AE}}{{Faizan}}<br />
==Overview==<br />
'''Aggressive fibromatosis''' is a rare condition marked by the presence of '''desmoid tumors'''. Desmoid tumors are tumors that arise from cells called fibroblasts. Fibroblasts are found throughout our body and their main function is to provide structural support and protection to the vital organs such as lung, liver, blood vessels, heart, kidneys, skin, intestines etc. and they also play a critical role in wound healing. When fibroblast cells undergo mutations they can become cancerous and become desmoid tumors (also known as "aggressive fibromatosis"). Desmoid tumors can arise in virtually any part of the body. These tumors often occur in women in their 30's, but can occur in anyone at any age. Desmoid tumors can be slow growing or extremely aggressive. These are slow-growing musculoaponeurotic tumors without any [[metastasis|metastatic]] potential. However, aggressive fibromatosis is locally aggressive. When they are aggressive they can cause life threatening problems or even death when they compress vital organs such as intestines, kidney, lungs, blood vessels, nerves etc. Most cases are sporadic, but some are associated with [[familial adenomatous polyposis]] (FAP). Approximately 10% of individuals with [[Gardner's syndrome]], a type of FAP with extracolonic features, have desmoid tumors.<ref name="pmid18237870">{{cite journal |author=Nieuwenhuis MH, De Vos Tot Nederveen Cappel W, Botma A |title=Desmoid tumors in a Dutch cohort of patients with familial adenomatous polyposis |journal=Clin. Gastroenterol. Hepatol. |volume=6 |issue=2 |pages=215–9 |date=February 2008 |pmid=18237870 |doi=10.1016/j.cgh.2007.11.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)01107-X|display-authors=etal}}</ref><br />
==Historical Perspective==<br />
==Classification==<br />
Desmoid tumor may be classified according to etiology into 5 subtypes.<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
==Pathophysiology==<br />
Desmoid tumor may occur as part of [[Gardner syndrome]]. A minority of desmoid tumors are associated with [[Turcot syndrome]], [[Familial adenomatous polyposis]], and estrogen therapy.<ref name="radio"> Desmoid tumor. Dr Tim Luijkx and Radswiki et al. Radiopedia 2015 http://radiopaedia.org/articles/aggressive-fibromatosis. Accessed on January 20, 2015</ref><br />
<br />
==Causes==<br />
There are no established direct causes for desmoid tumor.<br />
<br />
==Differentiating Desmoid tumor from other Diseases==<br />
Desmoid tumor must be differentiated from acute hematoma, [[lymphoma]], and [[fibrosarcoma]].<ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Epidemiology and Demographics==<br />
Desmoid tumor occurs in less than 0.03% of all tumors. The incidence of desmoid tumor is approximately 30 per 100,000 individuals worldwide. Females are more commonly affected with desmoid tumor than males. Desmoid tumor commonly affects individuals between 20 to 40 years of age.<ref name=aaa>Desmoid tumor. Dr Tim Luijkx and Radswiki et al.Radiopaedia 2015.http://radiopaedia.org/articles/desmoid-tumour. Accessed on January 21, 2016</ref><ref name="EconomouPitta2011">{{cite journal|last1=Economou|first1=Athanasios|last2=Pitta|first2=Xanthi|last3=Andreadis|first3=Efstathios|last4=Papapavlou|first4=Leonidas|last5=Chrissidis|first5=Thomas|title=Desmoid tumor of the abdominal wall: a case report|journal=Journal of Medical Case Reports|volume=5|issue=1|year=2011|pages=326|issn=1752-1947|doi=10.1186/1752-1947-5-326}}</ref><br />
<br />
==Risk Factors==<br />
Risk factors for desmoid disease amongst FAP patients include female sex, a 3' [[Adenomatous polyposis coli|APC mutation]], a positive family history and a history of previous abdominal surgery.<ref name="pmid20528895">{{cite journal |author=Sinha A, Clark SK|title=Risk factors predicting desmoid occurrence in patients with familial adenomatous polyposis: a meta-analysis |journal=Colorectal Dis. |pages=no |year=2010|pmid=20528895 |doi=10.1111/j.1463-1318.2010.02345.x |url= |volume=13 |issue=11}}</ref><br />
==Natural History, Complications and Prognosis==<br />
==History and Symptoms==<br />
==Physical Examination==<br />
==Laboratory Findings==<br />
==CT==<br />
==MRI==<br />
==Other Imaging Findings==<br />
==Other Diagnostic Studies==<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
==Reference==<br />
{{Reflist|2}}<br />
{{WikiDoc Help Menu}}<br />
{{WikiDoc Sources}}<br />
[[Category:Disease]]</div>Faizan Sheraz