https://www.wikidoc.org/api.php?action=feedcontributions&feedformat=atom&user=Annaja1Lwikidoc - User contributions [en]2026-04-06T19:57:17ZUser contributionsMediaWiki 1.45.1https://www.wikidoc.org/index.php?title=Melphalan&diff=618934Melphalan2011-12-19T20:44:04Z<p>Annaja1L: </p>
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<div>{{Drugbox|<br />
|IUPAC_name = 2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]-<br>propanoic acid<br />
| image=Melphalan.svg<br />
| CAS_number=148-82-3<br />
| ATC_prefix=L01<br />
| ATC_suffix=AA03<br />
| PubChem=4053<br />
| DrugBank=APRD00118<br />
| C = 13 | H = 18 | Cl = 2 | N = 2 | O = 2 <br />
| molecular_weight = 305.2 g/mol<br />
| bioavailability= 25% to 89%<br />
| metabolism = hydrolysis<br />
| elimination_half-life=1.5 ± 0.8 hours<br />
| excretion = [[Kidney|Renal]], significantly metabolised<br />
| pregnancy_AU = <br />
| pregnancy_US = <br />
| pregnancy_category = <br />
| legal_status = Rx-only<br />
| routes_of_administration= Oral, [[Intravenous therapy|intravenous]]<br />
}}<br />
'''Melphalan hydrochloride''' (trade name '''Alkeran''') is a [[chemotherapy]] [[medication|drug]] belonging to the class of [[nitrogen mustard]] [[alkylating antineoplastic agent|alkylating agent]]s. It is used primarily to treat [[multiple myeloma]] and [[ovarian cancer]], and occasionally [[malignant melanoma]]. Otherwise known as L-Phenylalanine Mustard, or L-PAM, melphalan is a [[phenylalanine]] derivative of [[mechlorethamine]]. The agent was first investigated as a possible drug for use in melanoma. It did not work, but was found to be of use in myeloma.<br />
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==Administration==<br />
Oral or intravenous; dosing varies by purpose and route of administration as well as patient weight.<br />
<br />
==Side effects==<br />
Common side effects include: <br />
*[[Nausea]] and vomiting<br />
*[[Bone marrow]] suppression, including<br />
**[[leukopenia|Decreased white blood cell count]] causing increased risk of [[infection]]<br />
**[[thrombocytopenia|Decreased platelet count]] causing increased risk of bleeding <br />
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Less common side effects include:<br />
*Severe allergic reactions<br />
*Scarring of lung tissue (usually only with prolonged use)<br />
*[[alopecia|Hair loss]]<br />
*[[Rash]]<br />
*[[pruritus|Itching]]<br />
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[[Category: chemotherapeutic agents]]<br />
{{pharma-stub}}<br />
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{{Chemotherapeutic agents}}<br />
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[[ja:メルファラン]]<br />
[[pl:Melfalan]]</div>Annaja1L