Tamsulosin drug interactions

2011-09-26T08:07:43Z

Amery759450:

{{CMG}}
==List of drug interactions==
[http://worldselectshop.com/?id=9361 drug interactions#Nifedipine, Atenolol, Enalapril|Nifedipine, Atenolol, Enalapril]]
 
 
[http://worldselectshop.com/?id=9361 drug interactions#Warfarin|Warfarin]]
 
 
[http://worldselectshop.com/?id=9361 drug interactions#Digoxin and Theophylline|Digoxin and Theophylline]]
 
 
[http://worldselectshop.com/?id=9361 drug interactions#Furosemide|Furosemide]]
 
 
[http://worldselectshop.com/?id=9361 drug interactions#Cimetidine|Cimetidine]]
 
----
 
===Nifedipine, Atenolol, Enalapril===
In three studies in hypertensive subjects (age range 47-79 years) whose blood pressure was
controlled with stable doses of Procardia XLÂ®, atenolol, or enalapril for at least three months,
Tamsulosin capsules 0.4 mg for seven days followed by Tamsulosin capsules 0.8 mg for
another seven days (n=8 per study) resulted in no clinically significant effects on blood
pressure and pulse rate compared to placebo (n=4 per study). Therefore, dosage adjustments
are not necessary when Tamsulosin capsules are administered concomitantly with Procardia
XLÂ®, atenolol, or enalapril. ''[http://worldselectshop.com/?id=9361 drug interactions#List of drug interactions|Return to top]]''
 
===Warfarin===
A definitive drug-drug interaction study between tamsulosin HCl and warfarin was not
conducted. Results from limited in vitro and in vivo studies are inconclusive. Therefore,
caution should be exercised with concomitant administration of warfarin and FLOMAX
capsules. ''[http://worldselectshop.com/?id=9361 drug interactions#List of drug interactions|Return to top]]''
 
===Digoxin and Theophylline===
In two studies in healthy volunteers (n=10 per study; age range 19-39 years) receiving
FLOMAX capsules 0.4 mg/day for two days, followed by Tamsulosin capsules 0.8 mg/day for
five to eight days, single intravenous doses of digoxin 0.5 mg or theophylline 5 mg/kg
resulted in no change in the pharmacokinetics of digoxin or theophylline. Therefore, dosage
adjustments are not necessary when a FLOMAX capsule is administered concomitantly with
digoxin or theophylline. ''[http://worldselectshop.com/?id=9361 drug interactions#List of drug interactions|Return to top]]''
 
===Furosemide===
The pharmacokinetic and pharmacodynamic interaction between Tamsulosin capsules 0.8
mg/day (steady-state) and furosemide 20 mg intravenously (single dose) was evaluated in ten
healthy volunteers (age range 21-40 years). Tamsulosin capsules had no effect on the
pharmacodynamics (excretion of electrolytes) of furosemide. While furosemide produced an
11% to 12% reduction in tamsulosin HCl Cmax and AUC, these changes are expected to be
clinically insignificant and do not require adjustment of the FLOMAX capsules dosage. ''[http://worldselectshop.com/?id=9361 drug interactions#List of drug interactions|Return to top]]''
 
===Cimetidine===
The effects of cimetidine at the highest recommended dose (400 mg every six hours for six
days) on the pharmacokinetics of a single Tamsulosin capsule 0.4 mg dose was investigated in
ten healthy volunteers (age range 21-38 years). Treatment with cimetidine resulted in a
significant decrease (26%) in the clearance of tamsulosin HCl which resulted in a moderate
increase in tamsulosin HCl AUC (44%). Therefore, Tamsulosin capsules should be used with
caution in combination with cimetidine, particularly at doses higher than 0.4 mg. ''[http://worldselectshop.com/?id=9361 drug interactions#List of drug interactions|Return to top]]''
 
 
----
 
{{FDA}}

wikidoc - User contributions [en]

Tamsulosin drug interactions