Fibrinogen c domain containing 1

2017-10-29T20:35:50Z

160.5.183.197: Expanded on the structure and function of the FIBCD1 protein.

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'''Fibrinogen C domain containing 1''' '''(FIBCD1)''' is a [[protein]] that in humans is encoded by the ''FIBCD1'' [[gene]] localized on [[Chromosome 9 (human)|chromosome]] 9q34.1 in close proximity to the genes encoding L- and M-ficolin.
<ref name="entrez">
{{cite web
| title = Entrez Gene: Fibrinogen C domain containing 1
| url = https://www.ncbi.nlm.nih.gov/gene/84929
| accessdate = 2016-03-08
}}</ref> FIBCD1 is thought to have a role in both host defence and gut homeostasis.

==Function==

FIBCD1 is a type II trans-membrane endocytic receptor that is expressed apically on enterocytes and on airway epithelial cells (Schlosser ''et al.'', 2009). It is thought to mediate the endocytosis of bound ligands which are released to the surroundings after degradation, with FIBCD1 being recycled to the plasma membrane.

The homology between FIBCD1 and members of the ficolins, which are extensively characterised pattern-recognition molecules that have roles in the immune response, indicate FIBCD1 may have a role in host defence. Two potential phosphorylation sites in the cytoplasmic part of FIBCD1 suggest that FIBCD1 also may be a signaling protein (Schlosser ''et al.'', 2009).

== Structure ==
FIBCD1 forms homo-tetramers in the plasma membrane, with each protein chain consisting of: a short cytoplasmic tail, a trans-membrane helix, and an ectodomain containing a coiled-coil region, a polycationic region, and a C-terminal fibrinogen-like recognition domain, otherwise known as the FReD (Shrive, ''et al.'', 2014)<ref>{{Cite journal|last=Shrive|first=Annette K.|last2=Moeller|first2=Jesper B.|last3=Burns|first3=Ian|last4=Paterson|first4=Jenny M.|last5=Shaw|first5=Amy J.|last6=Schlosser|first6=Anders|last7=Sorensen|first7=Grith L.|last8=Greenhough|first8=Trevor J.|last9=Holmskov|first9=Uffe|date=2014-01-31|title=Crystal Structure of the Tetrameric Fibrinogen-like Recognition Domain of Fibrinogen C Domain Containing 1 (FIBCD1) Protein|url=http://www.jbc.org/content/289/5/2880|journal=Journal of Biological Chemistry|language=en|volume=289|issue=5|pages=2880–2887|doi=10.1074/jbc.m113.520577|issn=0021-9258|pmid=24293368}}</ref>.

== References ==

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== Further reading ==

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*{{cite journal |vauthors=Schlosser A, Thomsen T, Moeller JB, Nielsen O, Tornøe I, Mollenhauer J, Moestrup SK, Holmskov U |title=Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin |journal=J. Immunol. |volume=183 |issue=6 |pages=3800–9 |year=2009 |pmid=19710473 |doi=10.4049/jimmunol.0901526 |url=}}
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[[Category:Human proteins]]

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Fibrinogen c domain containing 1