CUL1

2018-01-29T15:32:27Z

159.180.140.142: fixed COP9 link

{{Infobox_gene}}
'''Cullin 1''', also known as '''CUL1''', is a human protein and [[gene]] from [[cullin]] family.

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This protein plays an important role in [[protein degradation]] and protein [[ubiquitination]].

This is an essential component of the [[SCF-complex|SCF]] ([[SKP1]]-CUL1-[[F-box protein]]) E3 [[ubiquitin ligase]] complex, which mediates the [[ubiquitination]] of proteins involved in [[cell cycle]] progression, [[signal transduction]] and [[Transcription (genetics)|transcription]]. In the [[SCF complex]], it serves as a rigid scaffold that organizes the SKP1-F-box protein and [[RBX1]] subunits. May contribute to catalysis through positioning of the substrate and the [[ubiquitin-conjugating enzyme]].

This protein is a part of a SCF complex consisting of CUL1, [[RBX1]], [[SKP1]] and [[SKP2]]. It also interacts with [[RNF7]]. Part of a complex with [[TIP120A]]/[[CAND1]] and [[RBX1]]. The unneddylated form interacts with TIP120A/CAND1 and the interaction negatively regulates the association with SKP1 in the SCF complex. Interacts with [[COPS2]].

It is expressed in lung [[fibroblasts]].

The protein is [[Neddylation|neddylated]], which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the [[COP9 signalosome]] (CSN) complex.

==Further reading==
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{{PBB_Further_reading
| citations =
*{{cite journal | vauthors=Kipreos ET, Lander LE, Wing JP |title=cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. |journal=Cell |volume=85 |issue= 6 |pages= 829–39 |year= 1996 |pmid= 8681378 |doi=10.1016/S0092-8674(00)81267-2 |display-authors=etal}}
*{{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal | vauthors=Lisztwan J, Marti A, Sutterlüty H |title=Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. |journal=EMBO J. |volume=17 |issue= 2 |pages= 368–83 |year= 1998 |pmid= 9430629 |doi= 10.1093/emboj/17.2.368 | pmc=1170388 |display-authors=etal}}
*{{cite journal | vauthors=Michel JJ, Xiong Y |title=Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. |journal=Cell Growth Differ. |volume=9 |issue= 6 |pages= 435–49 |year= 1998 |pmid= 9663463 |doi= }}
*{{cite journal | vauthors=Ng RW, Arooz T, Yam CH |title=Characterization of the cullin and F-box protein partner Skp1. |journal=FEBS Lett. |volume=438 |issue= 3 |pages= 183–9 |year= 1998 |pmid= 9827542 |doi=10.1016/S0014-5793(98)01299-X |display-authors=etal}}
*{{cite journal | vauthors=Winston JT, Strack P, Beer-Romero P |title=The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. |journal=Genes Dev. |volume=13 |issue= 3 |pages= 270–83 |year= 1999 |pmid= 9990852 |doi=10.1101/gad.13.3.270 | pmc=316433 |display-authors=etal}}
*{{cite journal | vauthors=Tan P, Fuchs SY, Chen A |title=Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 527–33 |year= 1999 |pmid= 10230406 |doi=10.1016/S1097-2765(00)80481-5 |display-authors=etal}}
*{{cite journal | vauthors=Ohta T, Michel JJ, Schottelius AJ, Xiong Y |title=ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 535–41 |year= 1999 |pmid= 10230407 |doi=10.1016/S1097-2765(00)80482-7 }}
*{{cite journal | vauthors=Marti A, Wirbelauer C, Scheffner M, Krek W |title=Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. |journal=Nat. Cell Biol. |volume=1 |issue= 1 |pages= 14–9 |year= 1999 |pmid= 10559858 |doi= 10.1038/8984 }}
*{{cite journal | vauthors=Hori T, Osaka F, Chiba T |title=Covalent modification of all members of human cullin family proteins by NEDD8. |journal=Oncogene |volume=18 |issue= 48 |pages= 6829–34 |year= 2000 |pmid= 10597293 |doi= 10.1038/sj.onc.1203093 |display-authors=etal}}
*{{cite journal | vauthors=Read MA, Brownell JE, Gladysheva TB |title=Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2326–33 |year= 2000 |pmid= 10713156 |doi=10.1128/MCB.20.7.2326-2333.2000 | pmc=85397 |display-authors=etal}}
*{{cite journal | vauthors=Morimoto M, Nishida T, Honda R, Yasuda H |title=Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1). |journal=Biochem. Biophys. Res. Commun. |volume=270 |issue= 3 |pages= 1093–6 |year= 2000 |pmid= 10772955 |doi= 10.1006/bbrc.2000.2576 }}
*{{cite journal | vauthors=Swaroop M, Wang Y, Miller P |title=Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. |journal=Oncogene |volume=19 |issue= 24 |pages= 2855–66 |year= 2000 |pmid= 10851089 |doi= 10.1038/sj.onc.1203635 |display-authors=etal}}
*{{cite journal | vauthors=Furukawa M, Zhang Y, McCarville J |title=The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. |journal=Mol. Cell. Biol. |volume=20 |issue= 21 |pages= 8185–97 |year= 2000 |pmid= 11027288 |doi=10.1128/MCB.20.21.8185-8197.2000 | pmc=86428 |display-authors=etal}}
*{{cite journal | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
*{{cite journal | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
*{{cite journal | vauthors=Lyapina S, Cope G, Shevchenko A |title=Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. |journal=Science |volume=292 |issue= 5520 |pages= 1382–5 |year= 2001 |pmid= 11337588 |doi= 10.1126/science.1059780 |display-authors=etal}}
*{{cite journal | vauthors=Fukuchi M, Imamura T, Chiba T |title=Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. |journal=Mol. Biol. Cell |volume=12 |issue= 5 |pages= 1431–43 |year= 2001 |pmid= 11359933 |doi= 10.1091/mbc.12.5.1431| pmc=34595 |display-authors=etal}}
*{{cite journal | vauthors=Senadheera D, Haataja L, Groffen J, Heisterkamp N |title=The small GTPase Rac interacts with ubiquitination complex proteins Cullin-1 and CDC23. |journal=Int. J. Mol. Med. |volume=8 |issue= 2 |pages= 127–33 |year= 2001 |pmid= 11445862 |doi= 10.3892/ijmm.8.2.127}}
*{{cite journal | vauthors=Kiernan RE, Emiliani S, Nakayama K |title=Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome. |journal=Mol. Cell. Biol. |volume=21 |issue= 23 |pages= 7956–70 |year= 2001 |pmid= 11689688 |doi= 10.1128/MCB.21.23.7956-7970.2001 | pmc=99964 |display-authors=etal}}
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{{PDB Gallery|geneid=8454}}


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==External links==
* {{UCSC gene info|CUL1}}

{{gene-7-stub}}

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CUL1