TFB1M

2018-10-21T12:57:00Z

120.29.76.126: Humans

{{Infobox_gene}}
''' Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial''' is a mitochondrial [[enzyme]] that in 12-Eiael mag ingay is encoded by the ''TFB1M'' [[gene]].<ref name="pmid10810093">{{cite journal |vauthors=Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W | title = Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | journal = Genome Res | volume = 10 | issue = 5 | pages = 703–13 |date=Aug 2000 | pmid = 10810093 | pmc = 310876 | doi =10.1101/gr.10.5.703 }}</ref><ref name="pmid11809803">{{cite journal |vauthors=McCulloch V, Seidel-Rogol BL, Shadel GS | title = A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine | journal = Mol Cell Biol | volume = 22 | issue = 4 | pages = 1116–25 |date=Jan 2002 | pmid = 11809803 | pmc = 134642 | doi =10.1128/MCB.22.4.1116-1125.2002 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TFB1M transcription factor B1, mitochondrial| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51106| accessdate = }}</ref>
TFB1M is a mitochondrial methyltransferase, which uses [[S-adenosyl methionine]] to dimethylate two highly conserved [[adenosine]] residues at the 3'-end of the mitochondrial [[12S rRNA]] thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.<ref name="pmid11809803"/><ref name="pmid12068295">{{cite journal |vauthors=Falkenberg M, Gaspari M, Rantanen A, etal |title=Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 289–94 |year= 2002 |pmid= 12068295 |doi= 10.1038/ng909 }}</ref><ref name="pmid19356719">{{cite journal |author1=Metodiev MD |author2=Lesko N |author3=Park CB |author4=Camara Y. |author5=Shi Y. |author6=Wibom R. |author7=Hultenby K. |author8=Gustafsson CM |author9=Larsson NG. | title = Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome | journal = Cell Metab. | volume = 9 | issue = 4 | pages = 386–97 |date=Apr 2009 | pmid = 19356719 | doi =10.1016/j.cmet.2009.03.001}}</ref>

Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in an [[in vitro]] system containing recombinant mitochondrial RNA polymerase and [[TFAM]].<ref name="renamed_from_12068295_on_20140118095224">{{cite journal |vauthors=Falkenberg M, Gaspari M, Rantanen A, etal |title=Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 289–94 |year= 2002 |pmid= 12068295 |doi= 10.1038/ng909 }}</ref> There are no experimental data demonstrating that this function occurs [[in vivo]].

==Interactions==
TFB1M has been shown to [[Protein-protein interaction|interact]] with [[TFAM]].<ref name=pmid12897151>{{cite journal |doi=10.1128/MCB.23.16.5816-5824.2003 |last=McCulloch |first=Vicki |authorlink= |author2=Shadel Gerald S |date=Aug 2003 |title=Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity |journal=Mol. Cell. Biol. |volume=23 |issue=16 |pages=5816–24 |publisher= |location = United States| issn = 0270-7306| pmid = 12897151 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=166325 }}</ref>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal |vauthors=Falkenberg M, Gaspari M, Rantanen A, etal |title=Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. |journal=Nat. Genet. |volume=31 |issue= 3 |pages= 289–94 |year= 2002 |pmid= 12068295 |doi= 10.1038/ng909 }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal |vauthors=Seidel-Rogol BL, McCulloch V, Shadel GS |title=Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. |journal=Nat. Genet. |volume=33 |issue= 1 |pages= 23–4 |year= 2003 |pmid= 12496758 |doi= 10.1038/ng1064 }}
*{{cite journal |vauthors=Rantanen A, Gaspari M, Falkenberg M, etal |title=Characterization of the mouse genes for mitochondrial transcription factors B1 and B2. |journal=Mamm. Genome |volume=14 |issue= 1 |pages= 1–6 |year= 2003 |pmid= 12532263 |doi= 10.1007/s00335-002-2218-z }}
*{{cite journal |vauthors=McCulloch V, Shadel GS |title=Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. |journal=Mol. Cell. Biol. |volume=23 |issue= 16 |pages= 5816–24 |year= 2003 |pmid= 12897151 |doi=10.1128/MCB.23.16.5816-5824.2003 | pmc=166325 }}
*{{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal |vauthors=Bykhovskaya Y, Mengesha E, Wang D, etal |title=Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation. |journal=Mol. Genet. Metab. |volume=82 |issue= 1 |pages= 27–32 |year= 2004 |pmid= 15110318 |doi= 10.1016/j.ymgme.2004.01.020 }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal |vauthors=Gleyzer N, Vercauteren K, Scarpulla RC |title=Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. |journal=Mol. Cell. Biol. |volume=25 |issue= 4 |pages= 1354–66 |year= 2005 |pmid= 15684387 |doi= 10.1128/MCB.25.4.1354-1366.2005 | pmc=548005 }}
*{{cite journal |vauthors=Cotney J, Wang Z, Shadel GS |title=Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression. |journal=Nucleic Acids Res. |volume=35 |issue= 12 |pages= 4042–54 |year= 2007 |pmid= 17557812 |doi= 10.1093/nar/gkm424 | pmc=1919481 }}
}}
{{refend}}


{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

{{gene-6-stub}}

wikidoc - User contributions [en]

TFB1M